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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease

V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer and A.M. Michael
American Journal of Neuroradiology February 2020, 41 (2) 224-230; DOI: https://doi.org/10.3174/ajnr.A6402
V. Adduru
aFrom the Duke Institute for Brain Sciences (V.A., A.M.M.), Duke University, Durham, North Carolina
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
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S.A. Baum
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
dFaculty of Science (S.A.B.), University of Manitoba, Winnipeg, Manitoba, Canada
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C. Zhang
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
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M. Helguera
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
eInstituto Tecnológico José Mario Molina Pasquel y Henríquez (M.H.), Lagos de Moreno, Jalisco, Mexico.
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R. Zand
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
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M. Lichtenstein
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
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C.J. Griessenauer
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
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A.M. Michael
aFrom the Duke Institute for Brain Sciences (V.A., A.M.M.), Duke University, Durham, North Carolina
bNeuroscience Institute (V.A., C.Z., R.Z., M.L., C.J.G., A.M.M.), Geisinger Health System, Danville, Pennsylvania
cChester F. Carlson Center for Imaging Science (V.A., S.A.B., C.Z., M.H., A.M.M.), Rochester Institute of Technology, Rochester, New York
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  • FIG 1.
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    FIG 1.

    CTSeg pipeline for intracranial space and brain parenchyma segmentation from head CT images. Within parentheses is the 3D coordinate space of the image. MNI indicates Montreal Neurological Institute.

  • FIG 2.
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    FIG 2.

    Scatterplots (upper row) of automated-versus-manual volume estimates and the linear fit between automated and manual volumes (thick line) and the line of equality (thin line). Bland-Altman plots (lower row) with automated-minus-manual volume differences on the y-axis and the average of automated and manual volumes on the x-axis. Mean difference ±2 SDs is represented by dotted and dashed horizontal lines, respectively.

  • FIG 3.
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    FIG 3.

    Scatterplot of %TBV (left) estimated using CTSeg versus age. Scatterplot of TBV versus TIV (right).

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    Table 1:

    Comparison of automated TBV and TIV estimates with manual ground truth estimatesa

    Parameter/Method%DifferencePearson’s r (P Value)ICC (P Value)Bootstrap Mean ICC (95% CI)
    TBV
     CTSeg probabilistic–7.22±2.980.96 (<.001)0.74 (<.001)0.727 (0.724–0.730)
     CTSeg binarized1.58±3.460.95 (<.001)0.94 (<.001)0.937 (0.935–0.939)
    TIV
     CTSeg-probabilistic–12.15±1.440.99 (<.001)0.71 (<.001)0.685 (0.680–0.689)
     CTSeg binarized–3.28±1.360.99 (<.001)0.97 (<.001)0.962 (0.961–0.963)
     BET–5.12±0.6670.99 (<.001)0.94 (<.001)0.930 (0.928–0.932)
    • ↵a %Difference is reported as means.

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American Journal of Neuroradiology: 41 (2)
American Journal of Neuroradiology
Vol. 41, Issue 2
1 Feb 2020
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Cite this article
V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer, A.M. Michael
A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease
American Journal of Neuroradiology Feb 2020, 41 (2) 224-230; DOI: 10.3174/ajnr.A6402

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A Method to Estimate Brain Volume from Head CT Images and Application to Detect Brain Atrophy in Alzheimer Disease
V. Adduru, S.A. Baum, C. Zhang, M. Helguera, R. Zand, M. Lichtenstein, C.J. Griessenauer, A.M. Michael
American Journal of Neuroradiology Feb 2020, 41 (2) 224-230; DOI: 10.3174/ajnr.A6402
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