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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleSpine Imaging and Spine Image-Guided Interventions
Open Access

Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality Control

C. Chien, V. Juenger, M. Scheel, A.U. Brandt and F. Paul
American Journal of Neuroradiology February 2020, 41 (2) 343-350; DOI: https://doi.org/10.3174/ajnr.A6394
C. Chien
aFrom the Experimental and Clinical Research Center (C.C., V.J., A.U.B., F.P.), Max Delbrück Center for Molecular Medicine & Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
bNeuroCure Clinical Research Center (C.C., V.J., M.S., A.U.B., F.P.)
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V. Juenger
aFrom the Experimental and Clinical Research Center (C.C., V.J., A.U.B., F.P.), Max Delbrück Center for Molecular Medicine & Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
bNeuroCure Clinical Research Center (C.C., V.J., M.S., A.U.B., F.P.)
cDepartments of Neuroradiology (V.J., M.S.)
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M. Scheel
cDepartments of Neuroradiology (V.J., M.S.)
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A.U. Brandt
aFrom the Experimental and Clinical Research Center (C.C., V.J., A.U.B., F.P.), Max Delbrück Center for Molecular Medicine & Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
bNeuroCure Clinical Research Center (C.C., V.J., M.S., A.U.B., F.P.)
eDepartment of Neurology (A.U.B.), University of California, Irvine, Irvine, California.
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F. Paul
aFrom the Experimental and Clinical Research Center (C.C., V.J., A.U.B., F.P.), Max Delbrück Center for Molecular Medicine & Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
bNeuroCure Clinical Research Center (C.C., V.J., M.S., A.U.B., F.P.)
dNeurology (F.P.), Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
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Article Figures & Data

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  • FIG 1.
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    FIG 1.

    Comparison of effect sizes of differences between baseline MUCCA-Jim derived from the participants with longitudinal Day2day distortion-corrected (DD) DD and Day2day non-distortion-corrected (DND), clinical non-distortion-corrected (CND), Day2day distortion-corrected cross-sectional, and clinical non-distortion-corrected cross-sectional (CNDC) MPRAGE scans. Vertical lines beside dot plots indicate SDs around the means.

  • FIG 2.
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    FIG 2.

    Bland-Altman graph showing larger distortion-corrected MPRAGE-derived MUCCA-Jim values than non-distortion-corrected MPRAGE derived MUCCA-Jim, with relatively normally distributed mean values.

  • FIG 3.
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    FIG 3.

    Paired t test showing that the mean rescan MUCCA-Jim is quite stable when measured by an experienced rater from real-world non-distortion-corrected MPRAGE scans obtained, on average, 1 year apart.

  • FIG 4.
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    FIG 4.

    Consecutive sagittal MPRAGE scans. A and B, Large motion artifacts (session 1 MUCCA-Jim = 67.8 mm2, session 2 MUCCA-Jim = 53.1 mm2). C and D, Different head and neck (vertebrae level cutoff) positioning (session 1 MUCCA-Jim = 47.1 mm2, session 2 MUCCA-Jim  = 64.3 mm2). E and F, Metal implants in the mouth region (session 1 MUCCA-Jim = 73.8 mm2, session 2 MUCCA-Jim  = 79.7 mm2). Inlays show axial MUCCA regions, where the SC does not immediately seem different, but surrounding head/neck regions are often sliced differently. Red outline in images indicates the location of MUCCA segmentation.

Tables

  • Figures
  • CoVs for each Day2day participant MUCCA-Jim derived from distortion- and non-distortion-corrected MPRAGE scans

    ParticipantNo. of Rescan MPRAGE Scans CollectedNo. of Distortion-Corrected Derived MUCCAs AnalyzedCoV for Distortion-Corrected Derived MUCCANo. of Non-Distortion-Corrected Derived MUCCAs AnalyzedCoV for Non-Distortion-Corrected Derived MUCCA
    150501.36501.38
    213101.89101.72
    350373.09432.03
    411111.39101.35
    545401.40411.33
    647361.91421.55
    743431.35411.55
    849421.55431.40
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American Journal of Neuroradiology: 41 (2)
American Journal of Neuroradiology
Vol. 41, Issue 2
1 Feb 2020
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Cite this article
C. Chien, V. Juenger, M. Scheel, A.U. Brandt, F. Paul
Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality Control
American Journal of Neuroradiology Feb 2020, 41 (2) 343-350; DOI: 10.3174/ajnr.A6394

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Considerations for Mean Upper Cervical Cord Area Implementation in a Longitudinal MRI Setting: Methods, Interrater Reliability, and MRI Quality Control
C. Chien, V. Juenger, M. Scheel, A.U. Brandt, F. Paul
American Journal of Neuroradiology Feb 2020, 41 (2) 343-350; DOI: 10.3174/ajnr.A6394
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