Article Figures & Data
Figures
- Fig 1.
NeuroQuant triage brain atrophy report provides volumetric percentiles of left and right regions of the brain.
- Fig 2.
NeuroQuant hippocampal atrophy report provides volumetric percentiles of the left and right regions of the hippocampus as well as the normative percentile of the hippocampus compared with the normative control group of patients.
- Fig 3.
PPV of visual MR imaging analysis and NeuroQuant analysis results as the prevalence of HS increases. In our study, HS had a prevalence of 42.4% (black dotted line), NeuroQuant analysis had a PPV of 84%, and MR imaging had a PPV of 89.1%. With a decreased prevalence of HS, both MR imaging and NeuroQuant (NQ) have a decreased PPV, whereas an increased prevalence of HS results in a higher PPV for both analytic methods.
- Fig 4.
NPV of visual MR imaging analysis and NeuroQuant analysis results as the prevalence of HS increases. In our study, HS had a prevalence of 42.4% (black dotted line). In areas with a lower prevalence of HS than our institution, the NPV increases for both MR imaging and NeuroQuant.
Tables
- Table 1:
Sensitivities, specificities, PPVs, and NPVs, with varying cutoff points of NeuroQuant analysis
NeuroQuant Cutoff Point Sensitivity, % Specificity, % PPV, % NPV, % <7% 44.3 68.7 50.9 62.6 <6% 42.6 68.7 50.0 62.0 <5% 68.8 90.4 84.0 79.8 <4% 39.3 71.1 50.0 61.5 <3% 37.7 74.7 52.3 62.0 <2% 31.1 78.3 51.4 60.7 - Table 2:
Results for NeuroQuant analysis vs visual MR imaging analysis in identifying HS by using histopathology as the reference standard for HS
Sensitivity and Specificity Analysis Pathology Positive HS+ (n = 61) Pathology Negative HS– (n = 83) NeuroQuant Analysis Visual MR Imaging HS+ Visual MR Imaging HS– Visual MR Imaging HS+ Visual MR Imaging HS– HS+a 41 1 4 4 HS–b 16 3 3 72 Pathology HS+ Pathology HS– P Female, n/total n (%) 27/61 (44.3) 57.8/83 (57.8) .13 Age at surgery, mean ± SD, y 40.40 ± 14.3 35.36 ± 15.6 .05 MR imaging positive for HS, n/total n (%) 57/61 (93.4) 7/83 (8.4) <.0001 Ipsilateral hippocampus volume, mean ± SD (cm3) 9.98 ± 22.1 56.04 ± 32.3 <.0001 Contralateral hippocampus volume, mean ± SD (cm3) 52.79 ± 32.9 58.51 ± 30.0 .29 Surgery side - left, n/total n (%) 33/61 (54.1) 43/83 (51.8) .87 Note:—SD indicates standard deviation.
- Table 4:
Sensitivity and specificity values for NeuroQuant analysis and visual MR imaging analysis
NeuroQuant Analysis Visual MR Imaging Analysis P Sensitivity, % 68.8 93.4 .0007 Specificity, % 90.4 91.6 .99
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