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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Voxel-Based Morphometry—from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy

F. Riederer, R. Seiger, R. Lanzenberger, E. Pataraia, G. Kasprian, L. Michels, J. Beiersdorf, S. Kollias, T. Czech, J. Hainfellner and C. Baumgartner
American Journal of Neuroradiology June 2020, 41 (6) 987-993; DOI: https://doi.org/10.3174/ajnr.A6545
F. Riederer
aFrom the Hietzing Hospital with Neurological Center Rosenhügel & Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology (F.R., J.B., C.B.), Vienna, Austria
hFaculty of Medicine (F.R.), University of Zurich, Zurich, Switzerland
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R. Seiger
bNeuroimaging Labs, Department of Psychiatry and Psychotherapy (R.S., R.L.)
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R. Lanzenberger
bNeuroimaging Labs, Department of Psychiatry and Psychotherapy (R.S., R.L.)
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E. Pataraia
cDepartments of Neurology (E.P.)
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G. Kasprian
dRadiology and Nuclear Medicine (G.K.)
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L. Michels
gClinic of Neuroradiology (L.M., S.K.), University Hospital Zurich, Zurich, Switzerland
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J. Beiersdorf
aFrom the Hietzing Hospital with Neurological Center Rosenhügel & Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology (F.R., J.B., C.B.), Vienna, Austria
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S. Kollias
gClinic of Neuroradiology (L.M., S.K.), University Hospital Zurich, Zurich, Switzerland
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T. Czech
eNeurosurgery (T.C.)
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J. Hainfellner
fand Institute of Neurology (J.H.), Medical University of Vienna, Vienna, Austria
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C. Baumgartner
aFrom the Hietzing Hospital with Neurological Center Rosenhügel & Karl Landsteiner Institute for Clinical Epilepsy Research and Cognitive Neurology (F.R., J.B., C.B.), Vienna, Austria
iMedical Faculty (C.B.), Sigmund Freud Private University, Vienna, Austria.
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    Fig 1.

    Comparison of representative individual patients with right-sided TLE against a normal data base of 110 healthy controls. The color scale indicates the nonparametric t-value. Results are displayed at P < .05 corrected for multiple comparisons with family-wise error across the ROI. The scatterplot shows extracted hippocampal volumes/total intracranial volume for controls and patients (y-axis, institutionary units), where the individual patient is indicated with a blue arrow. Different symbols indicate the control cohorts. The x-axis indicates the age. Blue dotted lines show percentiles 5 and 95, respectively.

Tables

  • Figures
  • Sensitivity and specificity of single-subject VBM for the detection of hippocampal atrophy

    Sensitivity for the detection of hippocampal atrophy in patients with mesial temporal lobe epilepsya
    R Hippocampus decreaseL Hippocampus decrease
    0.92 (0.67–0.99)0.60 (0.31–0.83)
    Specificity of hippocampal volume changes
    R HippocampusL Hippocampus
    DecreaseIncreaseDecreaseIncrease
    Specificity0.99 (0.96–1.00)1.00 (0.97–1.00)0.99 (0.96–1.00)0.99 (0.96–1.00)
    Decrease or increase in R or L Hippocampus
    Specificity0.98 (0.93–0.99)
    • ↵aWilson 95% CI is given in brackets.

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American Journal of Neuroradiology: 41 (6)
American Journal of Neuroradiology
Vol. 41, Issue 6
1 Jun 2020
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F. Riederer, R. Seiger, R. Lanzenberger, E. Pataraia, G. Kasprian, L. Michels, J. Beiersdorf, S. Kollias, T. Czech, J. Hainfellner, C. Baumgartner
Voxel-Based Morphometry—from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy
American Journal of Neuroradiology Jun 2020, 41 (6) 987-993; DOI: 10.3174/ajnr.A6545

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Voxel-Based Morphometry—from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy
F. Riederer, R. Seiger, R. Lanzenberger, E. Pataraia, G. Kasprian, L. Michels, J. Beiersdorf, S. Kollias, T. Czech, J. Hainfellner, C. Baumgartner
American Journal of Neuroradiology Jun 2020, 41 (6) 987-993; DOI: 10.3174/ajnr.A6545
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