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Research ArticleAdult Brain
Open Access

COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke

P. Belani, J. Schefflein, S. Kihira, B. Rigney, B.N. Delman, K. Mahmoudi, J. Mocco, S. Majidi, J. Yeckley, A. Aggarwal, D. Lefton and A.H. Doshi
American Journal of Neuroradiology August 2020, 41 (8) 1361-1364; DOI: https://doi.org/10.3174/ajnr.A6650
P. Belani
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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  • ORCID record for P. Belani
J. Schefflein
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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S. Kihira
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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B. Rigney
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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B.N. Delman
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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K. Mahmoudi
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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J. Mocco
bNeurosurgery (J.M., S.M.), Icahn School of Medicine at Mount Sinai, New York, New York.
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S. Majidi
bNeurosurgery (J.M., S.M.), Icahn School of Medicine at Mount Sinai, New York, New York.
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J. Yeckley
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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A. Aggarwal
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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D. Lefton
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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A.H. Doshi
aFrom the Departments of Diagnostic, Molecular and Interventional Radiology (P.B., J.S., S.K., B.R., B.N.D., K.M., J.Y., A.A., D.L., A.H.D.)
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Article Figures & Data

Tables

  • Demographic characteristics of case and control subjects

    VariablesCases (n = 41)Controls (n = 82)P Value
    Age (mean) (yr)65.6 ± 1568.8 ± 13.24
    Male sex56.1% (23)56.1% (46)1.00
    COVID-19 (+)46.3% (19)18.3% (15).001
    Diabetes mellitus type 248.8% (20)43.9% (36).61
    Hypertension73.2% (30)73.2% (60)1.00
    Coronary artery disease29.3% (12)34.1% (28).59
    Congestive heart failure12.2% (5)15.9% (13).59
    Dyslipidemia43.9% (18)46.3% (38).80
    Atrial fibrillation29.3% (12)18.3% (15).18
    Prior stroke22% (9)31.7% (26).26
    BMI  = 25–29.9  kg/m222% (9)32.9% (27).21
    BMI >30 kg/m239% (16)23.2% (19).09
    Smoking status34.1% (14)28.0% (23).31
     Current12.2% (5)7.3% (6).29
     Former22% (9)20.7% (17).53
    • Note:—BMI indicates body mass index.

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American Journal of Neuroradiology: 41 (8)
American Journal of Neuroradiology
Vol. 41, Issue 8
1 Aug 2020
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Cite this article
P. Belani, J. Schefflein, S. Kihira, B. Rigney, B.N. Delman, K. Mahmoudi, J. Mocco, S. Majidi, J. Yeckley, A. Aggarwal, D. Lefton, A.H. Doshi
COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke
American Journal of Neuroradiology Aug 2020, 41 (8) 1361-1364; DOI: 10.3174/ajnr.A6650

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COVID-19 Is an Independent Risk Factor for Acute Ischemic Stroke
P. Belani, J. Schefflein, S. Kihira, B. Rigney, B.N. Delman, K. Mahmoudi, J. Mocco, S. Majidi, J. Yeckley, A. Aggarwal, D. Lefton, A.H. Doshi
American Journal of Neuroradiology Aug 2020, 41 (8) 1361-1364; DOI: 10.3174/ajnr.A6650
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    Journal of NeuroInterventional Surgery 2021 13 3
  • COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin
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    Frontiers in Medicine 2021 8
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