Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

J.-Y. Liu; Y.-J. Zhou; F.-F. Zhai; F. Han; L.-X. Zhou; J. Ni; M. Yao; S. Zhang; Z. Jin; L. Cui; Y.-C. Zhu

doi:10.3174/ajnr.A6622

Research ArticleAdult Brain

Open Access

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

J.-Y. Liu, Y.-J. Zhou, F.-F. Zhai, F. Han, L.-X. Zhou, J. Ni, M. Yao, S. Zhang, Z. Jin, L. Cui and Y.-C. Zhu

American Journal of Neuroradiology August 2020, 41 (8) 1397-1404; DOI: https://doi.org/10.3174/ajnr.A6622

J.-Y. Liu

aFrom the Departments of Neurology (J.-Y.L., Y.-J.Z., F.-F.Z., F.H., L.-X.Z., J.N., M.Y., L.C., Y.-C.Z.), Radiology (Z.J.), and Cardiology (S.Z.), Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for J.-Y. Liu

Y.-J. Zhou

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Y.-J. Zhou

F.-F. Zhai

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for F.-F. Zhai

F. Han

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for F. Han

L.-X. Zhou

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for L.-X. Zhou

J. Ni

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for J. Ni

M. Yao

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for M. Yao

S. Zhang

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for S. Zhang

Z. Jin

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Z. Jin

L. Cui

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for L. Cui

Y.-C. Zhu

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Y.-C. Zhu

Article
Figures & Data
Supplemental
Info & Metrics
Responses
References
PDF

Article Information

vol. 41 no. 8 1397-1404

DOI

https://doi.org/10.3174/ajnr.A6622

PubMed

32719091

Published By

American Journal of Neuroradiology

Print ISSN

0195-6108

Online ISSN

1936-959X

History

Received February 8, 2020
Accepted after revision May 1, 2020
Published online August 12, 2020.

Author Information

J.-Y. Liua,
Y.-J. Zhoua,
F.-F. Zhaia,
F. Hana,
L.-X. Zhoua,
J. Nia,
M. Yaoa,
S. Zhanga,
Z. Jina,
L. Cuia and
Y.-C. Zhua

^aFrom the Departments of Neurology (J.-Y.L., Y.-J.Z., F.-F.Z., F.H., L.-X.Z., J.N., M.Y., L.C., Y.-C.Z.), Radiology (Z.J.), and Cardiology (S.Z.), Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

Please address correspondence to Yi-Cheng Zhu, Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, No.1 Shuaifuyuan, Wangfujing, Beijing, 100730, China; e-mail: zhuych910{at}163.com

View Full Text

Funding

CAMS Innovation Fund for Medical Sciences
CIFMS #2017-I2M-3-008
Strategic Priority Research Program (Pilot study) “Biological basis of aging and therapeutic strategies” of the Chinese Academy of Sciences
XDPB10
National Key Research and Development Program of China
2017YFE0100500
National Natural Science Foundation of China
81671173

Altmetrics

Cited By...

14 Citations
16 Citations
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Disrupted topological organization of resting‐state functional brain networks in cerebral small vessel disease

Haotian Xin, Hongwei Wen, Mengmeng Feng, Yian Gao, Chaofan Sui, Nan Zhang, Changhu Liang, Lingfei Guo

Human Brain Mapping 2022 43 8
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease

Kenneth A. Rostowsky, Andrei Irimia

GeroScience 2021 43 4
Altered Spontaneous Brain Activity Related to Neurologic Dysfunction in Patients With Cerebral Small Vessel Disease

Mengmeng Feng, Hongwei Wen, Haotian Xin, Nan Zhang, Changhu Liang, Lingfei Guo

Frontiers in Aging Neuroscience 2021 13
Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building

Jing Sun, Ying Hui, Jing Li, Xinyu Zhao, Qian Chen, Xiaoshuai Li, Ning Wu, Mingze Xu, Wenjuan Liu, Rui Li, Pengfei Zhao, YunTao Wu, Aijun Xing, Huijing Shi, Shun Zhang, Xiaoliang Liang, Yongxin Wang, Han Lv, Shouling Wu, Zhenchang Wang

BMJ Open 2023 13 2
Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction

Shuichi Tonomura, Bibek Gyanwali

Neurochemistry International 2021 148
Iron deposition in the precuneus is correlated with mild cognitive impairment in patients with cerebral microbleeds: A quantitative susceptibility mapping study

Jing Tu, Jin Yan, Juan Liu, Dandan Liu, Xiaomeng Wang, Fei Gao

Frontiers in Neuroscience 2022 16
Contrast agent‐free state‐of‐the‐art magnetic resonance imaging on cerebral small vessel disease – Part 2: Diffusion tensor imaging and functional magnetic resonance imaging

Pedro Henrique Rodrigues da Silva, André Monteiro Paschoal, Kaio Felippe Secchinatto, Maria Clara Zanon Zotin, Antônio Carlos dos Santos, Anand Viswanathan, Octavio M. Pontes‐Neto, Renata Ferranti Leoni

NMR in Biomedicine 2022 35 8
Disrupted White Matter Integrity and Cognitive Functions in Amyloid-β Positive Alzheimer’s Disease with Concomitant Lobar Cerebral Microbleeds

Yanan Qiao, Yu Sun, Jing Guo, Yaojing Chen, Wenjie Hou, Junying Zhang, Dantao Peng

Journal of Alzheimer's Disease 2022 85 1
Role of White Matter Abnormalities in the Relationship Between Microbleed Burden and Cognitive Impairment in Cerebral Amyloid Angiopathy

Sungyang Jo, E-Nae Cheong, Nayoung Kim, Jungsu S. Oh, Woo Hyun Shim, Hyung-Ji Kim, Sun Ju Lee, Yoojin Lee, Minyoung Oh, Jae Seung Kim, Bum Joon Kim, Jee Hoon Roh, Sang Joon Kim, Jae-Hong Lee, Yi-Cheng Zhu

Journal of Alzheimer's Disease 2022 86 2
Disrupted brain structural networks associated with depression and cognitive dysfunction in cerebral small vessel disease with microbleeds

Haotian Xin, Changhu Liang, Yajie Fu, Mengmeng Feng, Shengpei Wang, Yian Gao, Chaofan Sui, Nan Zhang, Lingfei Guo, Hongwei Wen

Progress in Neuro-Psychopharmacology and Biological Psychiatry 2024 131
Impact of cerebral microbleeds on cognitive functions and its risk factors in acute cerebral infarction patients

Linyun Chen, Feng Liu, Xuan Tian, Tian Zhang, Jian Zhang, Fang Ran

Neurological Research 2023 45 6
MRI in older patients—A focused review

Stephan Seiler, Christian Enzinger

Seizure: European Journal of Epilepsy 2024
Risk Factor Analysis in Patients Exhibiting Cerebral Microbleeds and the Correlation with Cognitive Impairment

Yu Cui, Tong Zhao, Weifu Zhang, Rongguo Wang, Ming Hu, Xiying He, Ying Wang, Hongyan Xie

Gerontology and Geriatric Medicine 2024 10
Cerebral microbleeds linked to structural network disruption and cognitive impairment in white matter hyperintensities

Jiabin Yin, Xia Zhou, Yali Chen, Yue Sun, Chaojuan Huang, Yating Tang, Wenhao Zhu, Xiaoqun Zhu, Zhongwu Sun

Neuroscience 2025 564
Correlation Research Progress of Cerebral Small Vessel Disease

员演

Journal of Clinical Personalized Medicine 2025 04 01
The Dark Side of Cardiac and Aortic Interventions: Unveiling Cerebral Microbleeds with Susceptibility-Weighted Imaging

Tommaso Casseri, Maria Giulia Maccaglia, Ivano Lombardo, Andrea Bianchi, Rosaria Tartarone, Giorgio Busto, Andrea Ginestroni, Sara Speziali, Walter Dorigo, Enrico Fainardi

Journal of Vascular Diseases 2025 4 2

PreviousNext

In this issue

American Journal of Neuroradiology

Vol. 41, Issue 8

1 Aug 2020

Table of Contents
Index by author
Complete Issue (PDF)

Download PDF

Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

Message Subject (Your Name) has sent you a message from American Journal of Neuroradiology

Message Body (Your Name) thought you would like to see the American Journal of Neuroradiology web site.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Cite this article

J.-Y. Liu, Y.-J. Zhou, F.-F. Zhai, F. Han, L.-X. Zhou, J. Ni, M. Yao, S. Zhang, Z. Jin, L. Cui, Y.-C. Zhu

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

American Journal of Neuroradiology Aug 2020, 41 (8) 1397-1404; DOI: 10.3174/ajnr.A6622

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

0 Responses

Respond to this article

Bookmark this article

User Name *

Password *

Remember my user name & password.

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

J.-Y. Liu, Y.-J. Zhou, F.-F. Zhai, F. Han, L.-X. Zhou, J. Ni, M. Yao, S. Zhang, Z. Jin, L. Cui, Y.-C. Zhu

American Journal of Neuroradiology Aug 2020, 41 (8) 1397-1404; DOI: 10.3174/ajnr.A6622

Share This Article:

Tweet Widget
Facebook Like
Google Plus One

Purchase

Jump to section

Article
Figures & Data
Supplemental
Info & Metrics
Responses
References
PDF

PubMed
Google Scholar

Cited By...

Variations in perfusion detectable in advance of microstructure in white matter aging
Association of Cerebral Microbleeds and Risk of Stroke and Mortality in Posterior Circulation Cerebral Infarction
Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building

Crossref (16)
Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

Disrupted topological organization of resting‐state functional brain networks in cerebral small vessel disease

Haotian Xin, Hongwei Wen, Mengmeng Feng, Yian Gao, Chaofan Sui, Nan Zhang, Changhu Liang, Lingfei Guo

Human Brain Mapping 2022 43 8
Acute cognitive impairment after traumatic brain injury predicts the occurrence of brain atrophy patterns similar to those observed in Alzheimer’s disease

Kenneth A. Rostowsky, Andrei Irimia

GeroScience 2021 43 4
Altered Spontaneous Brain Activity Related to Neurologic Dysfunction in Patients With Cerebral Small Vessel Disease

Mengmeng Feng, Hongwei Wen, Haotian Xin, Nan Zhang, Changhu Liang, Lingfei Guo

Frontiers in Aging Neuroscience 2021 13
Protocol for Multi-modality MEdical imaging sTudy bAsed on KaiLuan Study (META-KLS): rationale, design and database building

Jing Sun, Ying Hui, Jing Li, Xinyu Zhao, Qian Chen, Xiaoshuai Li, Ning Wu, Mingze Xu, Wenjuan Liu, Rui Li, Pengfei Zhao, YunTao Wu, Aijun Xing, Huijing Shi, Shun Zhang, Xiaoliang Liang, Yongxin Wang, Han Lv, Shouling Wu, Zhenchang Wang

BMJ Open 2023 13 2
Cerebral microbleeds in vascular dementia from clinical aspects to host-microbial interaction

Shuichi Tonomura, Bibek Gyanwali

Neurochemistry International 2021 148
Iron deposition in the precuneus is correlated with mild cognitive impairment in patients with cerebral microbleeds: A quantitative susceptibility mapping study

Jing Tu, Jin Yan, Juan Liu, Dandan Liu, Xiaomeng Wang, Fei Gao

Frontiers in Neuroscience 2022 16
Contrast agent‐free state‐of‐the‐art magnetic resonance imaging on cerebral small vessel disease – Part 2: Diffusion tensor imaging and functional magnetic resonance imaging

Pedro Henrique Rodrigues da Silva, André Monteiro Paschoal, Kaio Felippe Secchinatto, Maria Clara Zanon Zotin, Antônio Carlos dos Santos, Anand Viswanathan, Octavio M. Pontes‐Neto, Renata Ferranti Leoni

NMR in Biomedicine 2022 35 8
Disrupted White Matter Integrity and Cognitive Functions in Amyloid-β Positive Alzheimer’s Disease with Concomitant Lobar Cerebral Microbleeds

Yanan Qiao, Yu Sun, Jing Guo, Yaojing Chen, Wenjie Hou, Junying Zhang, Dantao Peng

Journal of Alzheimer's Disease 2022 85 1
Role of White Matter Abnormalities in the Relationship Between Microbleed Burden and Cognitive Impairment in Cerebral Amyloid Angiopathy

Sungyang Jo, E-Nae Cheong, Nayoung Kim, Jungsu S. Oh, Woo Hyun Shim, Hyung-Ji Kim, Sun Ju Lee, Yoojin Lee, Minyoung Oh, Jae Seung Kim, Bum Joon Kim, Jee Hoon Roh, Sang Joon Kim, Jae-Hong Lee, Yi-Cheng Zhu

Journal of Alzheimer's Disease 2022 86 2
Disrupted brain structural networks associated with depression and cognitive dysfunction in cerebral small vessel disease with microbleeds

Haotian Xin, Changhu Liang, Yajie Fu, Mengmeng Feng, Shengpei Wang, Yian Gao, Chaofan Sui, Nan Zhang, Lingfei Guo, Hongwei Wen

Progress in Neuro-Psychopharmacology and Biological Psychiatry 2024 131

Adult Brain

Diagnostic Neuroradiology of Monoclonal Antibodies
ML for Glioma Molecular Subtype Prediction
Segmentation of Brain Metastases with BLAST

Show more Adult Brain

Functional

Glutaric Aciduria Type 1: DK vs. Conventional MRI
Kurtosis and Epileptogenic Tubers: A Pilot Study
Choroid Plexus Calcification&Microglial Activation

Show more Functional

Main menu

User menu

Search

American Journal of Neuroradiology

Cerebral Microbleeds Are Associated with Loss of White Matter Integrity

Article Information

Author Information

Funding

CAMS Innovation Fund for Medical Sciences

Strategic Priority Research Program (Pilot study) “Biological basis of aging and therapeutic strategies” of the Chinese Academy of Sciences

National Key Research and Development Program of China

National Natural Science Foundation of China

Altmetrics

Cited By...

In this issue

Citation Manager Formats

Related Articles

Cited By...

More in this TOC Section

Adult Brain

Functional

Similar Articles

Indexed Content

Cases

Special Collections

Resources

Multimedia

About Us

American Society of Neuroradiology