Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleAdult Brain
Open Access

Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas

S. Qu, T. Hu, O. Qiu, Y. Su, J. Gu and Z. Xia
American Journal of Neuroradiology August 2020, 41 (8) 1423-1429; DOI: https://doi.org/10.3174/ajnr.A6638
S. Qu
aFrom the Department of Neurosurgery (S.Q., T.H., O.Q., Y.S., Z.X.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Qu
T. Hu
aFrom the Department of Neurosurgery (S.Q., T.H., O.Q., Y.S., Z.X.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T. Hu
O. Qiu
aFrom the Department of Neurosurgery (S.Q., T.H., O.Q., Y.S., Z.X.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for O. Qiu
Y. Su
aFrom the Department of Neurosurgery (S.Q., T.H., O.Q., Y.S., Z.X.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Su
J. Gu
bDepartment of Neurosurgery (J.G.), Cancer Center, Sun Yat-sen University, Guangzhou, China.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Gu
Z. Xia
aFrom the Department of Neurosurgery (S.Q., T.H., O.Q., Y.S., Z.X.), First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Z. Xia
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Ostrom QT,
    2. Gittleman H,
    3. Truitt G, et al
    . CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015. Neuro Oncol 2018;20:iv1–86 doi:10.1093/neuonc/noy131 pmid:30445539
    CrossRefPubMed
  2. 2.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  3. 3.↵
    1. Chen X,
    2. Wanggou S,
    3. Bodalia A, et al
    . A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron 2018;100:799–815.e7 doi:10.1016/j.neuron.2018.09.046 pmid:30344046
    CrossRefPubMed
  4. 4.↵
    1. Ho VK,
    2. Reijneveld JC,
    3. Enting RH, et al
    . Changing incidence and improved survival of gliomas. Eur J Cancer 2014;50:2309–18 doi:10.1016/j.ejca.2014.05.019 pmid:24972545
    CrossRefPubMed
  5. 5.↵
    1. Hammoud MA,
    2. Sawaya R,
    3. Shi W, et al
    . Prognostic significance of preoperative MRI scans in glioblastoma multiforme. J Neurooncol 1996;27:65–73 doi:10.1007/BF00146086 pmid:8699228
    CrossRefPubMed
  6. 6.↵
    1. Schoenegger K,
    2. Oberndorfer S,
    3. Wuschitz B, et al
    . Peritumoral edema on MRI at initial diagnosis: an independent prognostic factor for glioblastoma? Eur J Neurol 2009;16:874–78 doi:10.1111/j.1468-1331.2009.02613.x pmid:19473360
    CrossRefPubMed
  7. 7.↵
    1. Wang P,
    2. Ni RY,
    3. Chen MN, et al
    . Expression of aquaporin-4 in human supratentorial meningiomas with peritumoral brain edema and correlation of VEGF with edema formation. Genet Mol Res 2011;10:2165–71 doi:10.4238/vol10-3gmr1212 pmid:21968684
    CrossRefPubMed
  8. 8.↵
    1. Hou J,
    2. Kshettry VR,
    3. Selman WR, et al
    . Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy. Neurosurg Focus 2013;35:E2 doi:10.3171/2013.8.FOCUS13301 pmid:24289127
    CrossRefPubMed
  9. 9.↵
    1. Sindou M,
    2. Alaywan M
    . Role of pia mater vascularization of the tumour in the surgical outcome of intracranial meningiomas. Acta Neurochir 1994;130:90–93 doi:10.1007/BF01405507 pmid:7725948
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Coste B,
    2. Mathur J,
    3. Schmidt M, et al
    . Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010;330:55–60 doi:10.1126/science.1193270 pmid:20813920
    Abstract/FREE Full Text
  11. 11.↵
    1. Friedrich EE,
    2. Hong Z,
    3. Xiong S, et al
    . Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions. Proc Natl Acad Sci U S A 2019;116:12980–85 doi:10.1073/pnas.1902165116 pmid:31186359
    Abstract/FREE Full Text
  12. 12.↵
    1. Guo L,
    2. Ding Z,
    3. Huang N, et al
    . Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death. Cell Cycle 2017;16:1705–18 doi:10.1080/15384101.2017.1356507 pmid:28767320
    CrossRefPubMed
  13. 13.↵
    1. Osawa T,
    2. Tosaka M,
    3. Nagaishi M, et al
    . Factors affecting peritumoral brain edema in meningioma: special histological subtypes with prominently extensive edema. J Neurooncol 2013;111:49–57 doi:10.1007/s11060-012-0989-y pmid:23104516
    CrossRefPubMed
  14. 14.↵
    Chinese Neurosurgical Society. Consensus on the drug treatment of peritumoral brain edema (in Chinese). Zhonghua Yi Xue Za Zhi 2010;90:5–9 pmid:20356516
    PubMed
  15. 15.↵
    1. Capper D,
    2. Weissert S,
    3. Balss J, et al
    . Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 2010;20:245–54 doi:10.1111/j.1750-3639.2009.00352.x pmid:19903171
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Kobayashi T,
    2. Masutomi K,
    3. Tamura K, et al
    . Nucleostemin expression in invasive breast cancer. BMC Cancer 2014;14:215 doi:10.1186/1471-2407-14-215 pmid:24650343
    CrossRefPubMed
  17. 17.↵
    1. Gawlitza M,
    2. Fiedler E,
    3. Schob S, et al
    . Peritumoral brain edema in meningiomas depends on aquaporin-4 expression and not on tumor grade, tumor volume, cell count, or Ki-67 labeling index. Mol Imaging Biol 2017;19:298–304 doi:10.1007/s11307-016-1000-7 pmid:27552812
    CrossRefPubMed
  18. 18.↵
    1. Zhang Y,
    2. Wang J,
    3. Zhang Y, et al
    . Overexpression of long noncoding RNA Malat1 ameliorates traumatic brain injury induced brain edema by inhibiting AQP4 and the NF-kappaB/IL-6 pathway. J Cell Biochem 2019;120:17584–92 doi:10.1002/jcb.29025 pmid:31218751
    CrossRefPubMed
  19. 19.↵
    1. Liang D,
    2. Bhatta S,
    3. Gerzanich V, et al
    . Cytotoxic edema: mechanisms of pathological cell swelling. Neurosurg Focus 2007;22:E2 doi:10.3171/foc.2007.22.5.3 pmid:17613233
    CrossRefPubMed
  20. 20.↵
    1. Heiss JD,
    2. Papavassiliou E,
    3. Merrill MJ, et al
    . Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats: involvement of the glucocorticoid receptor and vascular permeability factor. J Clin Invest 1996;98:1400–08 doi:10.1172/JCI118927 pmid:8823305
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Yu H,
    2. Yong Z,
    3. Yonggang W, et al
    . Correlational study of peritumoral brain edema, histological grades and the expression of Ki-67 in gliomas. Journal of International Oncology 2015;42:165–68
  22. 22.↵
    1. Lin ZX
    . Glioma-related edema: new insight into molecular mechanisms and their clinical implications. Chin J Cancer 2013;32:49–52 doi:10.5732/cjc.012.10242 pmid:23237218
    CrossRefPubMed
  23. 23.↵
    1. Tamiya T,
    2. Ono Y,
    3. Matsumoto K, et al
    . Peritumoral brain edema in intracranial meningiomas: effects of radiological and histological factors. Neurosurgery 2001;49:1046–51 doi:10.1097/00006123-200111000-00003 pmid:11846896
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Zhu L,
    2. Qi X-H,
    3. Kang Q-F, et al
    . The correlation of tumor volume, peritumoral edema with cerebral glioma histologic grade. Chinese J Magn Reson Imaging 2015;6:656–62
  25. 25.↵
    1. Baris MM,
    2. Celik AO,
    3. Gezer NS, et al
    . Role of mass effect, tumor volume and peritumoral edema volume in the differential diagnosis of primary brain tumor and metastasis. Clin Neurol Neurosurg 2016;148:67–71 doi:10.1016/j.clineuro.2016.07.008 pmid:27428485
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (8)
American Journal of Neuroradiology
Vol. 41, Issue 8
1 Aug 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S. Qu, T. Hu, O. Qiu, Y. Su, J. Gu, Z. Xia
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas
American Journal of Neuroradiology Aug 2020, 41 (8) 1423-1429; DOI: 10.3174/ajnr.A6638

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Effect of Piezo1 Overexpression on Peritumoral Brain Edema in Glioblastomas
S. Qu, T. Hu, O. Qiu, Y. Su, J. Gu, Z. Xia
American Journal of Neuroradiology Aug 2020, 41 (8) 1423-1429; DOI: 10.3174/ajnr.A6638
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (39)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators
    Hairong Tang, Ruoqing Zeng, Ende He, Isabella Zhang, Chunyong Ding, Ao Zhang
    Journal of Medicinal Chemistry 2022 65 9
  • Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer
    Jia-Lin Yu, Hai-Yang Liao
    Biomedicine & Pharmacotherapy 2021 140
  • PIEZO channels and newcomers in the mammalian mechanosensitive ion channel family
    Patrick Delmas, Thibaud Parpaite, Bertrand Coste
    Neuron 2022 110 17
  • Mechanosensitive ion channels in cell migration
    Brenda Canales Coutiño, Roberto Mayor
    Cells & Development 2021 166
  • Physiology and Pathophysiology of Mechanically Activated PIEZO Channels
    Ruhma Syeda
    Annual Review of Neuroscience 2021 44 1
  • Mechanosensitive Ion Channels and Their Role in Cancer Cells
    Julia Karska, Szymon Kowalski, Jolanta Saczko, Mihaela G. Moisescu, Julita Kulbacka
    Membranes 2023 13 2
  • Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system
    Boyi Zong, Fengzhi Yu, Xiaoyou Zhang, Yige Pang, Wenrui Zhao, Peng Sun, Lin Li
    Ageing Research Reviews 2023 90
  • PIEZO1 might be involved in cerebral ischemia-reperfusion injury through ferroptosis regulation: a hypothesis
    Xue-Wei Guo, Yan Lu, Hao Zhang, Jia-Qi Huang, Yong-Wang Li
    Medical Hypotheses 2021 146
  • Contribution of Oxidative Stress Induced by Sonodynamic Therapy to the Calcium Homeostasis Imbalance Enhances Macrophage Infiltration in Glioma Cells
    Lei Chen, Yang Yan, Fangen Kong, Jikai Wang, Jia Zeng, Zhen Fang, Zheyan Wang, Zhigang Liu, Fei Liu
    Cancers 2022 14 8
  • A New Hope in Spinal Degenerative Diseases: Piezo1
    Daxue Zhu, Guangzhi Zhang, Xudong Guo, Yidian Wang, Mingqiang Liu, Xuewen Kang, Pasquale De Bonis
    BioMed Research International 2021 2021 1

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Cerebral ADC Changes in Fabry Disease
  • ML for Glioma Molecular Subtype Prediction
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire