Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticleInterventional
Open Access

The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization

Z. Khashim, D. Daying, D.Y. Hong, J.A. Ringler, S. Herting, D. Jakaitis, D. Maitland, D.F. Kallmes and R. Kadirvel
American Journal of Neuroradiology September 2020, 41 (9) 1657-1662; DOI: https://doi.org/10.3174/ajnr.A6719
Z. Khashim
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Z. Khashim
D. Daying
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Daying
D.Y. Hong
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.Y. Hong
J.A. Ringler
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.A. Ringler
S. Herting
bDepartment of Biomedical Engineering (S.H., D.M.), Texas A&M University, College Station, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Herting
D. Jakaitis
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Jakaitis
D. Maitland
bDepartment of Biomedical Engineering (S.H., D.M.), Texas A&M University, College Station, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Maitland
D.F. Kallmes
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D.F. Kallmes
R. Kadirvel
aFrom the Department of Radiology (Z.K., D.D., D.Y.H., J.A.R., D.J., D.F.K., R.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Kadirvel
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Crobeddu E,
    2. Lanzino G,
    3. Kallmes DF, et al
    . Review of 2 decades of aneurysm-recurrence literature, part 1: reducing recurrence after endovascular coiling. AJNR Am J Neuroradiol 2013;34:266–70 doi:10.3174/ajnr.A3032 pmid:22422180
    Abstract/FREE Full Text
  2. 2.↵
    1. Crobeddu E,
    2. Lanzino G,
    3. Kallmes DF, et al
    . Review of 2 decades of aneurysm-recurrence literature, Part 2: managing recurrence after endovascular coiling. AJNR Am J Neuroradiol 2013;34:481–85 doi:10.3174/ajnr.A2958 pmid:22422182
    Abstract/FREE Full Text
  3. 3.↵
    1. Knap D,
    2. Gruszczyńska K,
    3. Partyka R, et al
    . Results of endovascular treatment of aneurysms depending on their size, volume and coil packing density. Neurol Neurochir Pol 2013;47:467–75 doi:10.5114/ninp.2013.38226 pmid:24166568
    CrossRefPubMed
  4. 4.↵
    1. Leng B,
    2. Zheng Y,
    3. Ren J, et al
    . Endovascular treatment of intracranial aneurysms with detachable coils: correlation between aneurysm volume, packing, and angiographic recurrence. J NeuroIntervent Surg 2014;6:595–99 doi:10.1136/neurintsurg-2013-010920 pmid:24107598
    Abstract/FREE Full Text
  5. 5.↵
    1. Ozawa T,
    2. Tamatani S,
    3. Koike T, et al
    . Histological evaluation of endothelial reactions after endovascular coil embolization for intracranial aneurysm: clinical and experimental studies and review of the literature. Interv Neuroradiol 2003;9:69–82 doi:10.1177/15910199030090S109 pmid:20591233
    CrossRefPubMed
  6. 6.↵
    1. Boecher-Schwarz HG,
    2. Ringel K,
    3. Kopacz L, et al
    . Ex vivo study of the physical effect of coils on pressure and flow dynamics in experimental aneurysms. AJNR Am J Neuroradiol 2000;21:1532–36 pmid:11003291
    Abstract/FREE Full Text
  7. 7.↵
    1. Ishihara S,
    2. Mawad ME,
    3. Ogata K, et al
    . Histopathologic findings in human cerebral aneurysms embolized with platinum coils: report of two cases and review of the literature. AJNR Am J Neuroradiol 2002;23:970–74 pmid:12063226
    Abstract/FREE Full Text
  8. 8.↵
    1. Shimizu S,
    2. Kurata A,
    3. Takano M, et al
    . Tissue response of a small saccular aneurysm after incomplete occlusion with a Guglielmi detachable coil. AJNR Am J Neuroradiol 1999;20:546–48 pmid:10319956
    Abstract/FREE Full Text
  9. 9.↵
    1. Ferrante CJ,
    2. Leibovich SJ
    . Regulation of macrophage polarization and wound healing. Adv Wound Care (New Rochelle) 2012;1:10–16 doi:10.1089/wound.2011.0307 pmid:24527272
    CrossRefPubMed
  10. 10.↵
    1. Hesketh M,
    2. Sahin KB,
    3. West ZE, et al
    . Macrophage phenotypes regulate scar formation and chronic wound healing. Int J Mol Sci 2017;18:1545 doi:10.3390/ijms18071545 pmid:28714933
    CrossRefPubMed
  11. 11.↵
    1. Zhou Y,
    2. Yoshida S,
    3. Kubo Y, et al
    . Different distributions of M1 and M2 macrophages in a mouse model of laser-induced choroidal neovascularization. Mol Med Rep 2017;15:3949–56 doi:10.3892/mmr.2017.6491 pmid:28440413
    CrossRefPubMed
  12. 12.
    1. Nawaz A,
    2. Aminuddin A,
    3. Kado T, et al
    . CD206(+) M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun 2017;8:286 doi:10.1038/s41467-017-00231-1 pmid:28819169
    CrossRefPubMed
  13. 13.
    1. Trombetta AC,
    2. Soldano S,
    3. Contini P, et al
    . A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement. Respir Res 2018;19:186 doi:10.1186/s12931-018-0891-z pmid:30249259
    CrossRefPubMed
  14. 14.↵
    1. Raggi F,
    2. Pelassa S,
    3. Pierobon D, et al
    . Regulation of human macrophage M1-M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1. Front Immunol 2017;8:1097 doi:10.3389/fimmu.2017.01097 pmid:28936211
    CrossRefPubMed
  15. 15.↵
    1. Khanna S,
    2. Biswas S,
    3. Shang Y, et al
    . Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice. PLoS One 2010;5:e9539 doi:10.1371/journal.pone.0009539 pmid:20209061
    CrossRefPubMed
  16. 16.↵
    1. Mirza R,
    2. Koh TJ
    . Dysregulation of monocyte/macrophage phenotype in wounds of diabetic mice. Cytokine 2011;56:256–64 doi:10.1016/j.cyto.2011.06.016 pmid:21803601
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Altes TA,
    2. Cloft HJ,
    3. Short JG, et al
    . 1999 ARRS Executive Council Award: creation of saccular aneurysms in the rabbit—a model suitable for testing endovascular devices. American Roentgen Ray Society. AJR Am J Roentgenol 2000;174:349–54 doi:10.2214/ajr.174.2.1740349 pmid:10658703
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Kallmes DF,
    2. Helm GA,
    3. Hudson SB, et al
    . Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits. Radiology 1999;213:217–22 doi:10.1148/radiology.213.1.r99oc16217 pmid:10540665
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Dai D,
    2. Ding YH,
    3. Kadirvel R, et al
    . Relationship between aneurysm volume and histologic healing after coil embolization in elastase-induced aneurysms: a retrospective study. AJNR Am J Neuroradiol 2008;29:98–101 doi:10.3174/ajnr.A0752 pmid:17925370
    Abstract/FREE Full Text
  20. 20.↵
    1. Herting SD,
    2. Boyle AJ,
    3. Dai D, et al
    . In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model. J Biomed Mater Res B Appl Biomater 2019;107:2466–75 doi:10.1002/jbm.b.34337 pmid:30775843
    CrossRefPubMed
  21. 21.↵
    1. Dai D,
    2. Yong-Hong D,
    3. Rezek I, et al
    . Healing of saccular aneurysms following platinum coil embolization: lack of improved efficacy with vitamin C supplementation. J Neurointerv Surg 2013;5:591–96 doi:10.1136/neurintsurg-2012-010421 pmid:22914744
    Abstract/FREE Full Text
  22. 22.↵
    1. Dai D,
    2. Ding YH,
    3. Danielson MA, et al
    . Endovascular treatment of experimental aneurysms with use of fibroblast transfected with replication-deficient adenovirus containing bone morphogenetic protein-13 gene. AJNR Am J Neuroradiol 2008;29:739–44 doi:10.3174/ajnr.A0892 pmid:18184848
    Abstract/FREE Full Text
  23. 23.↵
    1. Dai D,
    2. Ding YH,
    3. Lewis DA, et al
    . A proposed ordinal scale for grading histology in elastase-induced, saccular aneurysms. AJNR Am J Neuroradiol 2010;31:132–38 doi:10.3174/ajnr.A1781 pmid:16418372
    CrossRefPubMed
  24. 24.↵
    1. Murray PJ,
    2. Wynn TA
    . Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011;11:723–37 doi:10.1038/nri3073 pmid:21997792
    CrossRefPubMed
  25. 25.↵
    1. Goren I,
    2. Muller E,
    3. Schiefelbein D, et al
    . Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol 2007;127:2259–67 doi:10.1038/sj.jid.5700842 pmid:17460730
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Jetten N,
    2. Roumans N,
    3. Gijbels MJ, et al
    . Wound administration of M2-polarized macrophages does not improve murine cutaneous healing responses. PLoS one 2014;9:e102994 doi:10.1371/journal.pone.0102994 pmid:25068282
    CrossRefPubMed
  27. 27.↵
    1. Hoh BL,
    2. Hosaka K,
    3. Downes DP, et al
    . Monocyte chemotactic protein-1 promotes inflammatory vascular repair of murine carotid aneurysms via a macrophage inflammatory protein-1alpha and macrophage inflammatory protein-2-dependent pathway. Circulation 2011;124:2243–52 doi:10.1161/CIRCULATIONAHA.111.036061 pmid:22007074
    Abstract/FREE Full Text
  28. 28.↵
    1. Murayama Y,
    2. Tateshima S,
    3. Gonzalez NR, et al
    . Matrix and bioabsorbable polymeric coils accelerate healing of intracranial aneurysms: long-term experimental study. Stroke 2003;34:2031–37 doi:10.1161/01.STR.0000083394.33633.C2 pmid:12869719
    Abstract/FREE Full Text
  29. 29.↵
    1. McDougall CG,
    2. Johnston SC,
    3. Gholkar A, et al
    ; MAPS Investigators. Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial. AJNR Am J Neuroradiol 2014;35:935–42 doi:10.3174/ajnr.A3857 pmid:24481333
    Abstract/FREE Full Text
  30. 30.↵
    1. Pierot L,
    2. Cognard C,
    3. Ricolfi F, et al
    . CLARITY investigators. Mid-term anatomic results after endovascular treatment of ruptured intracranial aneurysms with Guglielmi detachable coils and Matrix coils: analysis of the CLARITY series. AJNR Am J Neuroradiol 2012;33:469–73 doi:10.3174/ajnr.A2771 pmid:22033712
    Abstract/FREE Full Text
  31. 31.↵
    1. Brinjikji W,
    2. Kallmes DF,
    3. Kadirvel R
    . Mechanisms of healing in coiled intracranial aneurysms: a review of the literature. AJNR Am J Neuroradiol 2015;36:1216–22 doi:10.3174/ajnr.A4175 pmid:25430855
    Abstract/FREE Full Text
  32. 32.↵
    1. Spiller KL,
    2. Anfang RR,
    3. Spiller KJ, et al
    . The role of macrophage phenotype in vascularization of tissue engineering scaffolds. Biomaterials 2014;35:4477–88 doi:10.1016/j.biomaterials.2014.02.012 pmid:24589361
    CrossRefPubMed
  33. 33.↵
    1. Kadirvel R,
    2. Ding YH,
    3. Dai D, et al
    . The influence of hemodynamic forces on biomarkers in the walls of elastase-induced aneurysms in rabbits. Neuroradiology 2007;49:1041–53 doi:10.1007/s00234-007-0295-0 pmid:17882410
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Herting SM,
    2. Ding Y,
    3. Boyle AJ, et al
    . In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model. J Biomed Mater Res Part B Appl Biomater 2019;107:2466–75 doi:10.1002/jbm.b.34337 pmid:30775843
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 41 (9)
American Journal of Neuroradiology
Vol. 41, Issue 9
1 Sep 2020
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Z. Khashim, D. Daying, D.Y. Hong, J.A. Ringler, S. Herting, D. Jakaitis, D. Maitland, D.F. Kallmes, R. Kadirvel
The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization
American Journal of Neuroradiology Sep 2020, 41 (9) 1657-1662; DOI: 10.3174/ajnr.A6719

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization
Z. Khashim, D. Daying, D.Y. Hong, J.A. Ringler, S. Herting, D. Jakaitis, D. Maitland, D.F. Kallmes, R. Kadirvel
American Journal of Neuroradiology Sep 2020, 41 (9) 1657-1662; DOI: 10.3174/ajnr.A6719
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • ACKNOWLEDGMENTS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Safety, Efficacy, and Durability of Stent-Assisted Coiling Treatment of M2 (Insular) Segment MCA Aneurysms
  • Endovascular Management of Intracranial Dural AVFs: Transvenous Approach
  • A Meta-analysis of Combined Aspiration Catheter and Stent Retriever versus Stent Retriever Alone for Large-Vessel Occlusion Ischemic Stroke
Show more INTERVENTIONAL

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire