Cervical Spinal Cord Compression and Sleep-Disordered Breathing in Syndromic Craniosynostosis

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FIGURE.
Axial and sagittal T2-weigthed MR imageing at the level of the odontoid process (above). Left: CR-1 measurement (anterior-posterior diameter/Latero-lateral diameter) Right: Perpendicular alignment for CR-1 measurement. Axial T1-weigthed MR image at the level of the foramen magnum and sagittal T2-weighted image in the midline (below). Left: CR-2 measurement (spinal cord area [yellow]/foramen magnum area × 100). Right: Cervicomedullary angle.

Table 1:

Characteristics of patients with syndromic craniosynostosis and controls

	Syndromic Craniosynostosis (n = 122)	Controls (n = 131)
Syndrome (No. of cases)
Apert	34	NA
Crouzon	65	NA
Muenke	12	NA
Saethre-Chotzen	11	NA
Mean age (yr)	5.70 (range, 0.24–18.92)	9.90 (range, 0.01–18.20)
Mean CR-1	0.63 (range, 0.32–1.03)	0.64 (range, 0.43–0.87)
Mean CR-2	0.41 (range, 0.12–1.00)	0.28 (range, 0.08–0.80)
Mean CMA	149.92 (range, 122.06–167.78)	157.07 (range, 136.04–174.21)

Table 2:

β coefficients and P values of the comparisons between patients with syndromic craniosynostosis and controls