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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Artificial Intelligence–Based 3D Angiography for Visualization of Complex Cerebrovascular Pathologies

S. Lang, P. Hoelter, M. Schmidt, C. Strother, C. Kaethner, M. Kowarschik and A. Doerfler
American Journal of Neuroradiology October 2021, 42 (10) 1762-1768; DOI: https://doi.org/10.3174/ajnr.A7252
S. Lang
aFrom the Department of Neuroradiology (S.L., P.H., M.S., A.D.), University of Erlangen-Nuremberg, Erlangen, Germany
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  • ORCID record for S. Lang
P. Hoelter
aFrom the Department of Neuroradiology (S.L., P.H., M.S., A.D.), University of Erlangen-Nuremberg, Erlangen, Germany
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  • ORCID record for P. Hoelter
M. Schmidt
aFrom the Department of Neuroradiology (S.L., P.H., M.S., A.D.), University of Erlangen-Nuremberg, Erlangen, Germany
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C. Strother
bDepartment of Radiology (C.S.), University of Wisconsin School of Medicine and Public Health, E3/366 Clinical Sciences Center, Madison, Wisconsin
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C. Kaethner
cAdvanced Therapies (C.K., M.K.), Siemens Healthcare GmbH, Forchheim, Germany
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M. Kowarschik
cAdvanced Therapies (C.K., M.K.), Siemens Healthcare GmbH, Forchheim, Germany
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A. Doerfler
aFrom the Department of Neuroradiology (S.L., P.H., M.S., A.D.), University of Erlangen-Nuremberg, Erlangen, Germany
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  • FIG 1.
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    FIG 1.

    Key aspects of the chosen network architecture. In addition to the in- and output of the network, kernel sizes, dilation rates, number of filters, and activation function (ie, rectified linear unit [ReLu]) are shown. Conv3D indicates 3D convolutional neural network.

  • FIG 2.
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    FIG 2.

    Sample measurement of the vascular dimensions of an ICA (C4 segment) in a 3D-DSA data set. The maximum vessel diameters have been assessed for both 3D-DSA and 3DA in 2 projections each (VD1 and VD2) using multiplanar reconstructions. A, Sagittal orientation of the C4 segment. B, Coronary orientation of the C4 segment. C, Finally, both vessel diameters allow the calculation of the VGI (VGI = VD1/VD2).

  • FIG 3.
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    FIG 3.

    Illustrative case 1. Sample visualization of a right-sided AVM with 3D-DSA (A) and the AI-based 3DA (B) using VRT. 3DA (B) shows both feeding arteries originating from the MCA and the nidus and drainage via superficial veins, equivalent to 3D-DSA. Not only the flow-associated aneurysm of the MCA bifurcation (red arrow) but also the venous ectasia adjacent to the nidus is comparably visualized without loss of information using 3DA.

  • FIG 4.
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    FIG 4.

    Illustrative case 2. Sample visualization of a left-sided dAVF with 3D-DSA (A) and the AI–based 3DA (B) using VRT. 3DA (B) offers comparable visualization of the influx of the fistula via the dilated middle meningeal artery and the drainage of the fistula via an ectatic cerebral vein compared with 3D-DSA (A).

  • FIG 5.
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    FIG 5.

    Illustrative case 3. Sample 3D visualization of an irregular aneurysm of the anterior communicating artery in VRT reconstructions using 3D-DSA (A) and 3DA (B). Despite differences concerning the reconstruction algorithm, AI-based 3DA (B) provides all relevant information on the aneurysmal configuration equivalent to 3D-DSA.

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    Table 1:

    Image quality

    GradeCharacteristics
    4Excellent (high contrast, no artifacts)
    3Good (high contrast; minimal artifacts, eg, due to movement or implants)
    2Compromised (eg, noticeable movement artifacts and/or reduced homogeneity of the vessel contrast)
    1Heavily compromised (low contrast and/or strong movement artifacts)
    0Not diagnostic (vasculature is not differentiable due to heavy artifacts and/or missing contrast)
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    Table 2:

    VD and VGI

    Parameter3DA (Mean)3D-DSA (Mean)rP
    VD1AVM3.82 (SD, 0.47) mm3.81 (SD, 0.55) mm0.988<.001
    VD2AVM3.97 (SD, 0.60) mm3.94 (SD, 0.59) mm0.984<.001
    VGIAVM0.96 (SD, 0.04) mm0.97 (SD, 0.03) mm0.835.003
    VD1CA4.39 (SD, 0.84) mm4.34 (SD, 0.87) mm0.998<.001
    VD2CA4.61 (SD, 0.81) mm4.54 (SD, 0.85) mm0.996<.001
    VGICA0.95 (SD, 0.04) mm0.95 (SD, 0.03) mm0.955<.001
    VD1dAVF4.24 (SD, 0.72) mm4.22 (SD, 0.77) mm0.993<.001
    VD2dAVF4.44 (SD, 0.780) mm4.43 (SD, 0.81) mm0.992<.001
    VGIdAVF0.95 (SD, 0.02) mm0.95 (SD, 0.02) mm0.824.003
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American Journal of Neuroradiology: 42 (10)
American Journal of Neuroradiology
Vol. 42, Issue 10
1 Oct 2021
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Cite this article
S. Lang, P. Hoelter, M. Schmidt, C. Strother, C. Kaethner, M. Kowarschik, A. Doerfler
Artificial Intelligence–Based 3D Angiography for Visualization of Complex Cerebrovascular Pathologies
American Journal of Neuroradiology Oct 2021, 42 (10) 1762-1768; DOI: 10.3174/ajnr.A7252

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Artificial Intelligence–Based 3D Angiography for Visualization of Complex Cerebrovascular Pathologies
S. Lang, P. Hoelter, M. Schmidt, C. Strother, C. Kaethner, M. Kowarschik, A. Doerfler
American Journal of Neuroradiology Oct 2021, 42 (10) 1762-1768; DOI: 10.3174/ajnr.A7252
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