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Research ArticleAdult Brain

Alterations in the Magnetoencephalography Default Mode Effective Connectivity following Concussion

D.D. Reddy, E.M. Davenport, F.F. Yu, B. Wagner, J.E. Urban, C.T. Whitlow, J.D. Stitzel and J.A. Maldjian
American Journal of Neuroradiology October 2021, 42 (10) 1776-1782; DOI: https://doi.org/10.3174/ajnr.A7232
D.D. Reddy
aFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas
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  • ORCID record for D.D. Reddy
E.M. Davenport
aFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas
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  • ORCID record for E.M. Davenport
F.F. Yu
aFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas
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B. Wagner
aFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas
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J.E. Urban
bWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina
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C.T. Whitlow
bWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina
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J.D. Stitzel
bWake Forest School of Medicine (J.E.U. C.T.W., J.D.S.), Winston-Salem, North Carolina
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J.A. Maldjian
aFrom the Department of Radiology (D.D.R., E.M.D., F.F.Y., B.W., J.A.M.), University of Texas Southwestern, Dallas, Texas
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    FIG 1.

    ROIs. DMN regions including the lateral orbitofrontal (LOF), medial orbitofrontal (MOF), and rostral anterior cingulate (rACC) regions grouped into anterior DMN regions are highlighted in red, and the precuneus (PCUN), posterior cingulate (PCC), and isthmus cingulate (iCC) regions grouped into posterior DMN regions are highlighted in blue. aDMN indicates anterior DMN; pDMN, posterior DMN.

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    FIG 2.

    Comparison of effective connectivity value changes across time. EC values at preseason, postconcussion, and postseason for the concussed group (left), EC values at preseason and postseason for the nonconcussed group (center), and EC values at preseason and postseason in controls (right).

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    FIG 3.

    Visual representation of averaged EC across subjects for the concussed (upper row), nonconcussed (lower left), and control (lower right) groups. The concussed group demonstrates a unidirectional increase in EC from preseason to immediately postconcussion (P = .013) and a decrease at postseason scan compared with the postconcussion scan (P = .028). The nonconcussed group and controls reveal no significant difference in EC between preseason and postseason scans.

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American Journal of Neuroradiology: 42 (10)
American Journal of Neuroradiology
Vol. 42, Issue 10
1 Oct 2021
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D.D. Reddy, E.M. Davenport, F.F. Yu, B. Wagner, J.E. Urban, C.T. Whitlow, J.D. Stitzel, J.A. Maldjian
Alterations in the Magnetoencephalography Default Mode Effective Connectivity following Concussion
American Journal of Neuroradiology Oct 2021, 42 (10) 1776-1782; DOI: 10.3174/ajnr.A7232

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Alterations in the Magnetoencephalography Default Mode Effective Connectivity following Concussion
D.D. Reddy, E.M. Davenport, F.F. Yu, B. Wagner, J.E. Urban, C.T. Whitlow, J.D. Stitzel, J.A. Maldjian
American Journal of Neuroradiology Oct 2021, 42 (10) 1776-1782; DOI: 10.3174/ajnr.A7232
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