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Research ArticleAdult Brain
Open Access

The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus

M. Borzage, A. Saunders, J. Hughes, J.G. McComb, S. Blüml and K.S. King
American Journal of Neuroradiology November 2021, 42 (11) 1942-1948; DOI: https://doi.org/10.3174/ajnr.A7294
M. Borzage
aFrom the Fetal and Neonatal Institute, Division of Neonatology (M.B.)
dDepartment of Pediatrics (M.B.)
fRudi Schulte Research Institute (M.B., A.S., S.B., K.S.K.), Santa Barbara, California
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A. Saunders
bDepartment of Radiology (A.S., S.B.)
fRudi Schulte Research Institute (M.B., A.S., S.B., K.S.K.), Santa Barbara, California
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J. Hughes
gDepartment of Neuroradiology (J.H., K.S.K.), Barrow Neurological Institute, Phoenix, Arizona
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J.G. McComb
cDivision of Neurosurgery (J.G.M.), Children’s Hospital Los Angeles, Los Angeles, California
eNeurological Surgery (J.G.M.), Keck School of Medicine, University of Southern California, Los Angeles, California
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S. Blüml
bDepartment of Radiology (A.S., S.B.)
fRudi Schulte Research Institute (M.B., A.S., S.B., K.S.K.), Santa Barbara, California
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K.S. King
fRudi Schulte Research Institute (M.B., A.S., S.B., K.S.K.), Santa Barbara, California
gDepartment of Neuroradiology (J.H., K.S.K.), Barrow Neurological Institute, Phoenix, Arizona
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Article Information

vol. 42 no. 11 1942-1948
DOI 
https://doi.org/10.3174/ajnr.A7294
PubMed 
34620589

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received March 5, 2021
  • Accepted after revision July 3, 2021
  • Published online November 11, 2021.

Copyright & Usage 
© 2021 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. M. Borzagea,d,f,
  2. A. Saundersb,f,
  3. J. Hughesg,
  4. J.G. McCombc,e,
  5. S. Blümlb,f and
  6. K.S. Kingf,g
  1. aFrom the Fetal and Neonatal Institute, Division of Neonatology (M.B.)
  2. bDepartment of Radiology (A.S., S.B.)
  3. cDivision of Neurosurgery (J.G.M.), Children’s Hospital Los Angeles, Los Angeles, California
  4. dDepartment of Pediatrics (M.B.)
  5. eNeurological Surgery (J.G.M.), Keck School of Medicine, University of Southern California, Los Angeles, California
  6. fRudi Schulte Research Institute (M.B., A.S., S.B., K.S.K.), Santa Barbara, California
  7. gDepartment of Neuroradiology (J.H., K.S.K.), Barrow Neurological Institute, Phoenix, Arizona
  1. Please address correspondence to A. Saunders, MS, Children’s Hospital of Los Angeles, Department of Radiology, 4650 Sunset Blvd., Los Angeles, CA 90027; e-mail: saundera{at}usc.edu
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Funding

  • Rudi Schulte Research Institute

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  • Pathophysiological Mechanisms Underlying Idiopathic Normal Pressure Hydrocephalus: A Review of Recent Insights
    Phillip A. Bonney, Robert G. Briggs, Kevin Wu, Wooseong Choi, Anadjeet Khahera, Brandon Ojogho, Xingfeng Shao, Zhen Zhao, Matthew Borzage, Danny J. J. Wang, Charles Liu, Darrin J. Lee
    Frontiers in Aging Neuroscience 2022 14
  • TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease
    Hunter White, Ryan Webb, Ian McKnight, Kaitlyn Legg, Chan Lee, Peter H.U. Lee, Olivia Smith Spicer, Joon W. Shim
    Frontiers in Genetics 2022 13
  • Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography
    Pragalv Karki, Matthew C. Murphy, Petrice M. Cogswell, Matthew L. Senjem, Jonathan Graff-Radford, Benjamin D. Elder, Avital Perry, Christopher S. Graffeo, Fredric B Meyer, Clifford R. Jack, Richard L. Ehman, John Huston
    American Journal of Neuroradiology 2024 45 3
  • Risk estimation for idiopathic normal-pressure hydrocephalus: development and validation of a brain morphometry–based nomogram
    Su Young Yun, Kyu Sung Choi, Chong Hyun Suh, Soo Chin Kim, Hwon Heo, Woo Hyun Shim, Sungyang Jo, Sun Ju Chung, Jae-Sung Lim, Jae-Hong Lee, Donghyun Kim, Seon-Ok Kim, Wooseok Jung, Ho Sung Kim, Sang Joon Kim, Ji-Hoon Kim
    European Radiology 2023 33 9
  • The compensatory mechanism and clinical significance of hydrocephalus after cranioplasty
    Xiansheng Qiu, Dong Wang, Li Chen, Guanlin Huang, Xiaoping Zhou, Qiang Chen, Zhanxiang Wang
    Frontiers in Neurology 2023 13
  • X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease
    Madeline Hart, Joshua Conrad, Emma Barrett, Kaitlyn Legg, Gabrielle Ivey, Peter H.U. Lee, Yun C. Yung, Joon W. Shim
    Experimental Neurology 2023 366
  • Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence–Based 3D T1 MRI Volumetric Analysis
    Joonhyung Lee, Dana Kim, Chong Hyun Suh, Suyoung Yun, Kyu Sung Choi, Seungjun Lee, Wooseok Jung, Jinyoung Kim, Hwon Heo, Woo Hyun Shim, Sungyang Jo, Sun Ju Chung, Jae-Sung Lim, Ho Sung Kim, Sang Joon Kim, Jae-Hong Lee
    American Journal of Neuroradiology 2025 46 1
  • Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer’s dementia and Parkinson’s disease, and hydrocephalus versus atrophy in chronic TBI—a narrative review
    Sharada Kadaba Sridhar, Jen Dysterheft Robb, Rishabh Gupta, Scarlett Cheong, Rui Kuang, Uzma Samadani
    Frontiers in Neurology 2024 15
  • Artificial Intelligence Approaches for the Detection of Normal Pressure Hydrocephalus: A Systematic Review
    Luis R. Mercado-Diaz, Neha Prakash, Gary X. Gong, Hugo F. Posada-Quintero
    Applied Sciences 2025 15 7
  • Automated Detection of Normal Pressure Hydrocephalus Using CT Imaging for Calculating the Ventricle-to-Subarachnoid Volume Ratio
    Jacob J. Knittel, Justin L. Hoskin, Dylan J. Hoyt, Jonathan A. Abdo, Emily L. Foldes, Molly M. McElvogue, Clay M. Oliver, Daniel A. Keesler, Terry D. Fife, F. David Barranco, Kris A. Smith, J. Gordon McComb, Matthew T. Borzage, Kevin S. King
    American Journal of Neuroradiology 2025 46 1
  • Callosal Angle Narrowing in Research Data Bases of the Cognitively Impaired
    M.U. Antonucci, L.M. McTeague, M. Yazdani, A. Benitez
    American Journal of Neuroradiology 2022 43 3
  • Corpus-Callosumwinkel: automatisierte vs. manuelle Messung
    Neuroradiologie Scan 2022 12 04
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Cite this article
M. Borzage, A. Saunders, J. Hughes, J.G. McComb, S. Blüml, K.S. King
The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus
American Journal of Neuroradiology Nov 2021, 42 (11) 1942-1948; DOI: 10.3174/ajnr.A7294

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The First Examination of Diagnostic Performance of Automated Measurement of the Callosal Angle in 1856 Elderly Patients and Volunteers Indicates That 12.4% of Exams Met the Criteria for Possible Normal Pressure Hydrocephalus
M. Borzage, A. Saunders, J. Hughes, J.G. McComb, S. Blüml, K.S. King
American Journal of Neuroradiology Nov 2021, 42 (11) 1942-1948; DOI: 10.3174/ajnr.A7294
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Cited By...

  • Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence-Based 3D T1 MRI Volumetric Analysis
  • Automated Detection of Normal Pressure Hydrocephalus Using CT Imaging for Calculating the Ventricle-to-Subarachnoid Volume Ratio
  • Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography
  • Callosal Angle Narrowing in Research Data Bases of the Cognitively Impaired
  • Crossref (12)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Pathophysiological Mechanisms Underlying Idiopathic Normal Pressure Hydrocephalus: A Review of Recent Insights
    Phillip A. Bonney, Robert G. Briggs, Kevin Wu, Wooseong Choi, Anadjeet Khahera, Brandon Ojogho, Xingfeng Shao, Zhen Zhao, Matthew Borzage, Danny J. J. Wang, Charles Liu, Darrin J. Lee
    Frontiers in Aging Neuroscience 2022 14
  • TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease
    Hunter White, Ryan Webb, Ian McKnight, Kaitlyn Legg, Chan Lee, Peter H.U. Lee, Olivia Smith Spicer, Joon W. Shim
    Frontiers in Genetics 2022 13
  • Prediction of Surgical Outcomes in Normal Pressure Hydrocephalus by MR Elastography
    Pragalv Karki, Matthew C. Murphy, Petrice M. Cogswell, Matthew L. Senjem, Jonathan Graff-Radford, Benjamin D. Elder, Avital Perry, Christopher S. Graffeo, Fredric B Meyer, Clifford R. Jack, Richard L. Ehman, John Huston
    American Journal of Neuroradiology 2024 45 3
  • Risk estimation for idiopathic normal-pressure hydrocephalus: development and validation of a brain morphometry–based nomogram
    Su Young Yun, Kyu Sung Choi, Chong Hyun Suh, Soo Chin Kim, Hwon Heo, Woo Hyun Shim, Sungyang Jo, Sun Ju Chung, Jae-Sung Lim, Jae-Hong Lee, Donghyun Kim, Seon-Ok Kim, Wooseok Jung, Ho Sung Kim, Sang Joon Kim, Ji-Hoon Kim
    European Radiology 2023 33 9
  • The compensatory mechanism and clinical significance of hydrocephalus after cranioplasty
    Xiansheng Qiu, Dong Wang, Li Chen, Guanlin Huang, Xiaoping Zhou, Qiang Chen, Zhanxiang Wang
    Frontiers in Neurology 2023 13
  • X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease
    Madeline Hart, Joshua Conrad, Emma Barrett, Kaitlyn Legg, Gabrielle Ivey, Peter H.U. Lee, Yun C. Yung, Joon W. Shim
    Experimental Neurology 2023 366
  • Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence–Based 3D T1 MRI Volumetric Analysis
    Joonhyung Lee, Dana Kim, Chong Hyun Suh, Suyoung Yun, Kyu Sung Choi, Seungjun Lee, Wooseok Jung, Jinyoung Kim, Hwon Heo, Woo Hyun Shim, Sungyang Jo, Sun Ju Chung, Jae-Sung Lim, Ho Sung Kim, Sang Joon Kim, Jae-Hong Lee
    American Journal of Neuroradiology 2025 46 1
  • Structural neuroimaging markers of normal pressure hydrocephalus versus Alzheimer’s dementia and Parkinson’s disease, and hydrocephalus versus atrophy in chronic TBI—a narrative review
    Sharada Kadaba Sridhar, Jen Dysterheft Robb, Rishabh Gupta, Scarlett Cheong, Rui Kuang, Uzma Samadani
    Frontiers in Neurology 2024 15
  • Artificial Intelligence Approaches for the Detection of Normal Pressure Hydrocephalus: A Systematic Review
    Luis R. Mercado-Diaz, Neha Prakash, Gary X. Gong, Hugo F. Posada-Quintero
    Applied Sciences 2025 15 7
  • Automated Detection of Normal Pressure Hydrocephalus Using CT Imaging for Calculating the Ventricle-to-Subarachnoid Volume Ratio
    Jacob J. Knittel, Justin L. Hoskin, Dylan J. Hoyt, Jonathan A. Abdo, Emily L. Foldes, Molly M. McElvogue, Clay M. Oliver, Daniel A. Keesler, Terry D. Fife, F. David Barranco, Kris A. Smith, J. Gordon McComb, Matthew T. Borzage, Kevin S. King
    American Journal of Neuroradiology 2025 46 1

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