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Research ArticlePediatrics

MRI Patterns in Pediatric CNS Hemophagocytic Lymphohistiocytosis

P. Malik, L. Antonini, P. Mannam, F.N. Aboobacker, A. Merve, K. Gilmour, K. Rao, S. Kumar, S.E. Mani, D. Eleftheriou, A. Rao, C. Hemingway, S.V. Sudhakar, J. Bartram and K. Mankad
American Journal of Neuroradiology November 2021, 42 (11) 2077-2085; DOI: https://doi.org/10.3174/ajnr.A7292
P. Malik
aFrom the Departments of Diagnostic Imaging (P. Malik, P. Mannam, S.E.M.)
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L. Antonini
dDepartment of Paediatric Hemato-Oncology (L.A.), G. Salesi Hospital, Ancona, Italy
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P. Mannam
aFrom the Departments of Diagnostic Imaging (P. Malik, P. Mannam, S.E.M.)
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F.N. Aboobacker
bHematology (F.N.A.)
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A. Merve
gDepartment of Histopathology (A.M.)
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K. Gilmour
jImmunology (K.G.)
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K. Rao
hBone Marrow Transplant Unit (K.R.)
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S. Kumar
cChild Heath (S.K.), Christian Medical College, Vellore, India
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S.E. Mani
aFrom the Departments of Diagnostic Imaging (P. Malik, P. Mannam, S.E.M.)
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D. Eleftheriou
kPaediatric Rheumatology (D.E.), Great Ormond Street Hospital for Children and University College, London, UK
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A. Rao
iDepartment of Pediatric Hematology (A.R., J.B.)
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C. Hemingway
eDepartment of Pediatric Neurology (C.H.)
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S.V. Sudhakar
fPediatric Neuroradiology Unit (S.V.S., K.M.)
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J. Bartram
iDepartment of Pediatric Hematology (A.R., J.B.)
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K. Mankad
fPediatric Neuroradiology Unit (S.V.S., K.M.)
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Article Information

vol. 42 no. 11 2077-2085
DOI 
https://doi.org/10.3174/ajnr.A7292
PubMed 
34620587

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received May 12, 2021
  • Accepted after revision July 19, 2021
  • Published online November 11, 2021.

Copyright & Usage 
© 2021 by American Journal of Neuroradiology

Author Information

  1. P. Malika,
  2. L. Antoninid,
  3. P. Mannama,
  4. F.N. Aboobackerb,
  5. A. Merveg,
  6. K. Gilmourj,
  7. K. Raoh,
  8. S. Kumarc,
  9. S.E. Mania,
  10. D. Eleftheriouk,
  11. A. Raoi,
  12. C. Hemingwaye,
  13. S.V. Sudhakarf,
  14. J. Bartrami and
  15. K. Mankadf
  1. aFrom the Departments of Diagnostic Imaging (P. Malik, P. Mannam, S.E.M.)
  2. bHematology (F.N.A.)
  3. cChild Heath (S.K.), Christian Medical College, Vellore, India
  4. dDepartment of Paediatric Hemato-Oncology (L.A.), G. Salesi Hospital, Ancona, Italy
  5. eDepartment of Pediatric Neurology (C.H.)
  6. fPediatric Neuroradiology Unit (S.V.S., K.M.)
  7. gDepartment of Histopathology (A.M.)
  8. hBone Marrow Transplant Unit (K.R.)
  9. iDepartment of Pediatric Hematology (A.R., J.B.)
  10. jImmunology (K.G.)
  11. kPaediatric Rheumatology (D.E.), Great Ormond Street Hospital for Children and University College, London, UK
  1. Please address correspondence to Kshitij Mankad, MD, Pediatric Neuroradiology unit, Great Ormond St Hospital for Children, Great Ormond St, London WC1N 3JH, UK; e-mail: drmankad{at}gmail.com; @PrateekM77; @drmankad; @SSudhakar2019
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Cite this article
P. Malik, L. Antonini, P. Mannam, F.N. Aboobacker, A. Merve, K. Gilmour, K. Rao, S. Kumar, S.E. Mani, D. Eleftheriou, A. Rao, C. Hemingway, S.V. Sudhakar, J. Bartram, K. Mankad
MRI Patterns in Pediatric CNS Hemophagocytic Lymphohistiocytosis
American Journal of Neuroradiology Nov 2021, 42 (11) 2077-2085; DOI: 10.3174/ajnr.A7292

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MRI Patterns in Pediatric CNS Hemophagocytic Lymphohistiocytosis
P. Malik, L. Antonini, P. Mannam, F.N. Aboobacker, A. Merve, K. Gilmour, K. Rao, S. Kumar, S.E. Mani, D. Eleftheriou, A. Rao, C. Hemingway, S.V. Sudhakar, J. Bartram, K. Mankad
American Journal of Neuroradiology Nov 2021, 42 (11) 2077-2085; DOI: 10.3174/ajnr.A7292
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Cited By...

  • Isolated central nervous system haemophagocytic lymphohistiocytosis with PRF1 gene mutation presenting as fever of unknown origin
  • Child Neurology: Familial Hemophagocytic Lymphohistiocytosis Underlying Isolated CNS Inflammation
  • Crossref (19)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Child Neurology: Familial Hemophagocytic Lymphohistiocytosis Underlying Isolated CNS Inflammation
    Giorgia Bucciol, Nele Willemyns, Benjamin Verhaaren, Xavier Bossuyt, Katrien Lagrou, Anniek Corveleyn, Despina Moshous, Katrien Jansen, Liesbeth De Waele, Isabelle Meyts
    Neurology 2022 99 15
  • Childhood Cerebral Vasculitis
    Neetika Gupta, Shivaprakash B. Hiremath, Richard I. Aviv, Nagwa Wilson
    Clinical Neuroradiology 2023 33 1
  • Imaging Spectrum of Neurological Manifestations of Hemophagocytic Lymphohistiocytosis in Pediatrics: A Case Series
    Geethapriya Sivaramalingam, Afiya VK, Bagyam Raghavan, Jayaraj Govindaraj
    Indian Journal of Radiology and Imaging 2023 33 04
  • Case report: Cerebellar swelling and hydrocephalus in familial hemophagocytic lymphohistiocytosis
    Taro Yoshida, Kunihiko Moriya, Keisuke Oikawa, Shoko Miura, Yoshiko Asakura, Sachiko Tanifuji, Shuji Kusano, Mikiya Endo, Manami Akasaka
    Frontiers in Pediatrics 2022 10
  • Differential Diagnosis of Suspected Multiple Sclerosis in Pediatric and Late-Onset Populations
    Le H. Hua, Andrew J. Solomon, Silvia Tenembaum, Antonio Scalfari, Àlex Rovira, Kevin Rostasy, Scott D. Newsome, Ruth Ann Marrie, Melinda Magyari, Orhun Kantarci, Bernhard Hemmer, Cheryl Hemingway, Mary Pat Harnegie, Jennifer S. Graves, Jeffrey A. Cohen, Riley Bove, Brenda Banwell, John R. Corboy, Emmanuelle Waubant
    JAMA Neurology 2024 81 11
  • Infection and inflammation: radiological insights into patterns of pediatric immune-mediated CNS injury
    Prateek Malik, Manohar Shroff
    Neuroradiology 2023 65 3
  • Isolated Sixth Nerve Palsies in a Child With Familial Hemophagocytic Lymphohistiocytosis Type 2
    Homer H. Chiang, Sebastian Fernandez-Pol, Gordon H. Bae, Kerri E. Rieger, Hisham M. Dahmoush, Shannon J. Beres
    Journal of Neuro-Ophthalmology 2023 43 1
  • Neurobrucellosis Presenting as Vocal Cord Paralysis in an Infant: Correspondence
    Prateek Kumar Panda, Indar Kumar Sharawat
    Indian Journal of Pediatrics 2024 91 12
  • Pediatric CNS-isolated hemophagocytic lymphohistiocytosis with brain hemorrhages: a case report
    Mauricio Borda, Helen Tian, Steven Benitez, Ashley Bonheur, Nagma Dalvi, Ellen Fraint
    BMC Neurology 2024 24 1
  • Silvery Gray Hair Syndrome With Hemophagocytic Lymphohistiocytosis: A Case Report
    Shiji Chalipat, Vishwanath Kulkarni, Sudhir Malwade, Priyanka Shah, Prasad Bijaspur
    Cureus 2024

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