Correlation of Technical and Adjunctive Factors with Quantitative Tumor Reduction in Children Undergoing Selective Ophthalmic Artery Infusion Chemotherapy for Retinoblastoma

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FIG 1.
Composite photograph shows 2 eyes of 2 individual patients with macular retinoblastoma displaying substantially different QTRs at 3–4 weeks after the first cycle of selective ophthalmic artery infusion chemotherapy. Analysis of the top pair of photos gives a QTR of 15% and a DTR classified as poor (QTR < 50%). Analysis of the bottom pair of photos gives a QTR of 95% and DTR classified as satisfactory (QTR > 50%).
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FIG 2.
The absolute number of satisfactory (black) or poor (white) DTRs for first cycle of SOAIC treatments performed with or without adjunctive IAV is presented for the aggregate study population (A), SOAIC treatments performed with single-agent melphalan at any dose (B), and SOAIC treatments performed with single-agent melphalan at doses of <5 mg (C).
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FIG 3.
The average QTR is presented for the first cycle of selective ophthalmic artery infusion chemotherapy treatment differentiated into brief (<20 minutes), intermediate (20–38 minutes), and prolonged (≥39 minutes) CIT intervals. Error bars indicate ± 1 SD.

Age, sex, history of familial retinoblastoma, and tumor laterality

		Average Patient Age (mo) [SD]	Female Sex (Fraction of Total Patients)	Familial Retinoblastoma (Fraction of Total Eyes)	Tumor Laterality
		Average Patient Age (mo) [SD]	Female Sex (Fraction of Total Patients)	Familial Retinoblastoma (Fraction of Total Eyes)	Bilateral Tumors (Fraction of Total Eyes)	Right-Sided Tumors (Fraction of Total Eyes)	Left-Sided Tumors (Fraction of Total Eyes)
Aggregate study population n = 21 eyes, n = 20 patients		19.5 [SD, 14.7]	12 (0.60)	2 (0.09)	2 (0.09)	10 (0.48)	11
Eyes treated with IAV	+ (n = 15 eyes)	15.4 [SD, 11.1]	8 (0.53)	2 (0.13)	2 (0.13)	6 (0.40)	9 (0.60)
Eyes treated with IAV	– (n = 6 eyes)	29.7 [SD, 16.5]	4 (0.67)	0(0.0)	0 (0.0)	4 (0.67)	2 (0.33)
Eyes treated with INA	+ (n = 14 eyes)	17.7 [SD, 15.1]	8 (0.57)	2 (0.14)	2 (0.14)	8 (0.57)	6 (0.43)
Eyes treated with INA	– (n = 7 eyes)	23.1 [SD, 14.0]	4 (0.57)	0 (0.0)	0 (0.0)	2 (0.29)	5 (0.71)
Eyes treated with adjunctive ECBO	+ (n = 14 eyes)	14.3 [SD, 9.5]	8 (0.57)	2 (0.14)	1 (0.07)	5 (0.36)	9 (0.64)
Eyes treated with adjunctive ECBO	– (n = 7 eyes)	30.0 [SD, 18.2]	4 (0.57)	0 (0.0)	1 (0.14)	5 (0.71)	2 (0.29)
Eye status according to DTR	Satisfactory (n = 15 eyes)	16.4 [SD, 10.0]	7 (0.47)	1 (0.07)	2 (0.13)	7 (0.47)	8 (0.53)
Eye status according to DTR	Poor (n = 6 eyes)	27.3 [SD, 21.8]	5 (0.83)	1 (0.17)	0 (0.0)	3 (0.50)	3 (0.50)