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Research ArticleAdult Brain
Open Access

A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images

L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin and for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology April 2021, 42 (4) 639-647; DOI: https://doi.org/10.3174/ajnr.A6970
L. Umapathy
aFrom the Departments of Electrical and Computer Engineering (L.U., A.B.)
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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G.G. Perez-Carrillo
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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M.B. Keerthivasan
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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J.A. Rosado-Toro
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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M.I. Altbach
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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B. Winegar
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
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C. Weinkauf
cSurgery (C.W.)
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A. Bilgin
aFrom the Departments of Electrical and Computer Engineering (L.U., A.B.)
bMedical Imaging (L.U., G.G.P.-C., M.B.K., J.A.R.-T., M.I.A., B.W., A.B.)
dBiomedical Engineering (A.B.), University of Arizona, Tucson, Arizona
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References

  1. 1.↵
    1. Fazekas F,
    2. Kleinert R,
    3. Offenbacher H, et al
    . Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993;43:1683–83 doi:10.1212/WNL.43.9.1683 pmid:8414012
    CrossRefPubMed
  2. 2.↵
    1. Brickman AM,
    2. Meier IB,
    3. Korgaonkar MS, et al
    . Testing the white matter retrogenesis hypothesis of cognitive aging. Neurobiol Aging 2012;33:1699–1715 doi:10.1016/j.neurobiolaging.2011.06.001 pmid:21783280
    CrossRefPubMed
  3. 3.↵
    1. Chutinet A,
    2. Rost NS
    . White matter disease as a biomarker for long-term cerebrovascular disease and dementia. Curr Treat Options Cardiovasc Med 2014;16:392 doi:10.1007/s11936-013-0292-z pmid:24496967
    CrossRefPubMed
  4. 4.↵
    1. Carmichael O,
    2. Schwarz C,
    3. Drucker D, et al
    . Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer Disease Neuroimaging Initiative. Arch Neurol 2010;67:1370– 78 doi:10.1001/archneurol.2010.284 pmid:21060014
    CrossRefPubMed
  5. 5.↵
    1. Bendfeldt K,
    2. Blumhagen JO,
    3. Egger H, et al
    . Spatiotemporal distribution pattern of white matter lesion volumes and their association with regional grey matter volume reductions in relapsing-remitting multiple sclerosis. Hum Brain Mapp 2010;31:1542–55 doi:10.1002/hbm.20951 pmid:20108225
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Fazekas F,
    2. Chawluk JB,
    3. Alavi A, et al
    . MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 1987;149:351–56 doi:10.2214/ajr.149.2.351 pmid:3496763
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Litjens G,
    2. Kooi T,
    3. Bejnordi BE, et al
    . A survey on deep learning in medical image analysis. Med Image Anal 2017;42:60–88 doi:10.1016/j.media.2017.07.005 pmid:28778026
    CrossRefPubMed
  8. 8.↵
    1. Rachmadi MF,
    2. Valdés-Hernández MD,
    3. Agan ML, et al
    ; Alzheimer’s Disease Neuroimaging Initiative. Segmentation of white matter hyperintensities using convolutional neural networks with global spatial information in routine clinical brain MRI with none or mild vascular pathology. Comput Med Imaging Graph 2018;66:28–43 doi:10.1016/j.compmedimag.2018.02.002 pmid:29523002
    CrossRefPubMed
  9. 9.↵
    1. Guerrero R,
    2. Qin C,
    3. Oktay O, et al
    . White matter hyperintensity and stroke lesion segmentation and differentiation using convolutional neural networks. Neuroimage Clin 2018;17:918–34 doi:10.1016/j.nicl.2017.12.022 pmid:29527496
    CrossRefPubMed
  10. 10.↵
    1. Li H,
    2. Jiang G,
    3. Zhang J, et al
    . Fully convolutional network ensembles for white matter hyperintensities segmentation in MR images. Neuroimage 2018;183:650–65 doi:10.1016/j.neuroimage.2018.07.005 pmid:30125711
    CrossRefPubMed
  11. 11.↵
    1. Ghafoorian M,
    2. Karssemeijer N,
    3. Heskes T, et al
    . Location sensitive deep convolutional neural networks for segmentation of white matter hyperintensities. Sci Rep 2017;7:1–12 doi:10.1038/s41598-017-05300-5 pmid:28698556
    CrossRefPubMed
  12. 12.↵
    1. Kuijf HJ,
    2. Casamitjana A,
    3. Collins DL, et al
    . Standardized assessment of automatic segmentation of white matter hyperintensities and results of the WMH segmentation challenge. IEEE Trans Med Imaging 2019;38:2556–68 doi:10.1109/TMI.2019.2905770 pmid:30908194
    CrossRefPubMed
  13. 13.↵
    1. Bink A,
    2. Schmitt M,
    3. Gaa J, et al
    . Detection of lesions in multiple sclerosis by 2D FLAIR and single-slab 3D FLAIR sequences at 3.0 T: initial results. Eur Radiol 2006;16:1104–10 doi:10.1007/s00330-005-0107-z pmid:16425026
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Valverde S,
    2. Cabezas M,
    3. Roura E, et al
    . Improving automated multiple sclerosis lesion segmentation with a cascaded 3D convolutional neural network approach. Neuroimage 2017;155:159–68 doi:10.1016/j.neuroimage.2017.04.034 pmid:28435096
    CrossRefPubMed
  15. 15.↵
    1. Kushibar K,
    2. Valverde S,
    3. González-Villà S, et al
    . Automated sub-cortical brain structure segmentation combining spatial and deep convolutional features. Med Image Anal 2018;48:177–86 doi:10.1016/j.media.2018.06.006 pmid:29935442
    CrossRefPubMed
  16. 16.↵
    1. Kamnitsas K,
    2. Ledig C,
    3. Newcombe VFJ, et al
    . Efficient multi-scale 3D CNN with fully connected CRF for accurate brain lesion segmentation. Med Image Anal 2017;36:61–78 doi:10.1016/j.media.2016.10.004 pmid:27865153
    CrossRefPubMed
  17. 17.↵
    1. Kamnitsas K,
    2. Bai W,
    3. Ferrante E, et al
    . Ensembles of multiple models and architectures for robust brain tumour segmentation. In: International MICCAI Brainlesion Workshop: Springer; 2017: 450–62 Accessed September 14, 2017
  18. 18.↵
    1. Wolpert DH
    . Stacked generalization. Neural Networks 1992;5:241–59 doi:10.1016/S0893-6080(05)80023-1
    CrossRefWeb of Science
  19. 19.↵
    1. Ronneberger O,
    2. Fischer P,
    3. Brox T
    . U-Net: convolutional networks for biomedical image segmentation. May 2015. http://arxiv.org/abs/1505.04597. Accessed July 19, 2019
  20. 20.↵
    1. Smith SM
    . Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–55 doi:10.1002/hbm.10062 pmid:12391568
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Tustison NJ,
    2. Avants BB,
    3. Cook PA, et al
    . N4ITK: improved N3 bias correction. IEEE Trans Med Imaging 2010;29:1310–20 doi:10.1109/TMI.2010.2046908 pmid:20378467
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Abadi M,
    2. Agarwal A,
    3. Barham P, et al
    . Tensorflow: large-scale machine learning on heterogeneous distributed systems. February 28, 2016. https://arxiv.org/abs/1603.04467v2. Accessed April 25, 2020
  23. 23.↵
    1. Schmidt P,
    2. Gaser C,
    3. Arsic M, et al
    . An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis. Neuroimage 2012;59:3774–83 doi:10.1016/j.neuroimage.2011.11.032 pmid:22119648
    CrossRefPubMed
  24. 24.↵
    1. Xing Y,
    2. Wang J,
    3. Chen X, et al
    . 2.5D convolution for RGB-D semantic segmentation. In: Proceedings of the International Conference on Image Processing (ICIP), Taipei, Tiwan. September 22–25, 2019 doi:10.1109/ICIP.2019.8803757
    CrossRef
  25. 25.↵
    1. Ghafoorian M,
    2. Karssemeijer N,
    3. Heskes T, et al
    . Deep multi-scale location-aware 3D convolutional neural networks for automated detection of lacunes of presumed vascular origin. Neuroimage Clin 2017;14:391–99 doi:10.1016/j.nicl.2017.01.033 pmid:28271039
    CrossRefPubMed
  26. 26.↵
    1. Duong MT,
    2. Rudie JD,
    3. Wang J, et al
    . Convolutional neural network for automated flair lesion segmentation on clinical brain MR imaging. AJNR Am J Neuroradiol 2019;40:1282–90 doi:10.3174/ajnr.A6138 pmid:31345943
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L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin, for the Alzheimer’s Disease Neuroimaging Initiative
A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images
American Journal of Neuroradiology Apr 2021, 42 (4) 639-647; DOI: 10.3174/ajnr.A6970

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A Stacked Generalization of 3D Orthogonal Deep Learning Convolutional Neural Networks for Improved Detection of White Matter Hyperintensities in 3D FLAIR Images
L. Umapathy, G.G. Perez-Carrillo, M.B. Keerthivasan, J.A. Rosado-Toro, M.I. Altbach, B. Winegar, C. Weinkauf, A. Bilgin, for the Alzheimer’s Disease Neuroimaging Initiative
American Journal of Neuroradiology Apr 2021, 42 (4) 639-647; DOI: 10.3174/ajnr.A6970
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