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Research ArticleAdult Brain
Open Access

MGMT Promoter Methylation Status in Initial and Recurrent Glioblastoma: Correlation Study with DWI and DSC PWI Features

H.J. Choi, S.H. Choi, S.-H. You, R.-E. Yoo, K.M. Kang, T.J. Yun, J.-h. Kim, C.-H. Sohn, C.-K. Park and S.-H. Park
American Journal of Neuroradiology May 2021, 42 (5) 853-860; DOI: https://doi.org/10.3174/ajnr.A7004
H.J. Choi
aFrom the Department of Radiology (H.J.C.), Cha Bundang Medical Center, Cha University, Seongnam, Korea
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  • ORCID record for H.J. Choi
S.H. Choi
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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S.-H. You
cDepartment of Radiology (S.-H.Y.), Korea University Hospital, Seoul, Korea
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R.-E. Yoo
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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K.M. Kang
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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T.J. Yun
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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J.-h. Kim
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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C.-H. Sohn
bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
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C.-K. Park
dDepartment of Neurosurgery (C.-K.P.), Seoul National University Hospital, Seoul, Korea
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S.-H. Park
eDepartment of Pathology (S.-H.P.), Seoul National University Hospital, Seoul, Korea
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Article Information

vol. 42 no. 5 853-860
DOI 
https://doi.org/10.3174/ajnr.A7004
PubMed 
33632732

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received July 28, 2020
  • Accepted after revision November 16, 2020
  • Published online May 12, 2021.

Copyright & Usage 
© 2021 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. H.J. Choia,
  2. S.H. Choib,
  3. S.-H. Youc,
  4. R.-E. Yoob,
  5. K.M. Kangb,
  6. T.J. Yunb,
  7. J.-h. Kimb,
  8. C.-H. Sohnb,
  9. C.-K. Parkd and
  10. S.-H. Parke
  1. aFrom the Department of Radiology (H.J.C.), Cha Bundang Medical Center, Cha University, Seongnam, Korea
  2. bDepartment of Radiology (S.H.C., R.-E.Y., K.M.K., T.J.Y., J.-h.K., C.-H.S.), Seoul National University Hospital, Seoul, Korea
  3. cDepartment of Radiology (S.-H.Y.), Korea University Hospital, Seoul, Korea
  4. dDepartment of Neurosurgery (C.-K.P.), Seoul National University Hospital, Seoul, Korea
  5. eDepartment of Pathology (S.-H.P.), Seoul National University Hospital, Seoul, Korea
  1. Please address correspondence to Seung Hong Choi, MD, PhD, Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea; e-mail: verocay{at}snuh.org
View Full Text

Funding

  • Brain Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning National Research Foundation of Korea funded by the Korea government (MSIT)

    NRF-2016M3C7A1914002 (NRF-2020R1G1A11027701)
  • Korea Healthcare technology R&D Projects, Ministry for Health, Welfare & Family Affairs

    HI16C1111
  • Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning

    NRF-2020R1A2C2008949 and NRF-2020R1A4A1018714
  • Creative-Pioneering Researchers Program through Seoul National University (SNU), and by the Institute for Basic Science

    IBS-R006-A1

Altmetrics

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H.J. Choi, S.H. Choi, S.-H. You, R.-E. Yoo, K.M. Kang, T.J. Yun, J.-h. Kim, C.-H. Sohn, C.-K. Park, S.-H. Park
MGMT Promoter Methylation Status in Initial and Recurrent Glioblastoma: Correlation Study with DWI and DSC PWI Features
American Journal of Neuroradiology May 2021, 42 (5) 853-860; DOI: 10.3174/ajnr.A7004

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MGMT Promoter Methylation Status in Initial and Recurrent Glioblastoma: Correlation Study with DWI and DSC PWI Features
H.J. Choi, S.H. Choi, S.-H. You, R.-E. Yoo, K.M. Kang, T.J. Yun, J.-h. Kim, C.-H. Sohn, C.-K. Park, S.-H. Park
American Journal of Neuroradiology May 2021, 42 (5) 853-860; DOI: 10.3174/ajnr.A7004
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  • Advanced Distance-Resolved Evaluation of the Perienhancing Tumor Areas with FLAIR Hyperintensity Indicates Different ADC Profiles by MGMT Promoter Methylation Status in Glioblastoma
  • Crossref (18)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Genotoxic therapy and resistance mechanism in gliomas
    Fengchao Lang, Yang Liu, Fu-Ju Chou, Chunzhang Yang
    Pharmacology & Therapeutics 2021 228
  • Imaging biomarkers for clinical applications in neuro-oncology: current status and future perspectives
    Fang-Ying Chiu, Yun Yen
    Biomarker Research 2023 11 1
  • Validation of MRI-Based Models to Predict MGMT Promoter Methylation in Gliomas: BraTS 2021 Radiogenomics Challenge
    Byung-Hoon Kim, Hyeonhoon Lee, Kyu Sung Choi, Ju Gang Nam, Chul-Kee Park, Sung-Hye Park, Jin Wook Chung, Seung Hong Choi
    Cancers 2022 14 19
  • Qualitative and Quantitative Magnetic Resonance Imaging Phenotypes May Predict CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytomas: A Multicenter Study
    Yae Won Park, Ki Sung Park, Ji Eun Park, Sung Soo Ahn, Inho Park, Ho Sung Kim, Jong Hee Chang, Seung-Koo Lee, Se Hoon Kim
    Korean Journal of Radiology 2023 24 2
  • Reclassification of Glioblastoma Multiforme According to the 2021 World Health Organization Classification of Central Nervous System Tumors: A Single Institution Report and Practical Significance
    George S Stoyanov, Emran Lyutfi, Reneta Georgieva, Radoslav Georgiev, Deyan L Dzhenkov, Lilyana Petkova, Borislav D Ivanov, Ara Kaprelyan, Peter Ghenev
    Cureus 2022
  • Hemodynamic Imaging in Cerebral Diffuse Glioma—Part B: Molecular Correlates, Treatment Effect Monitoring, Prognosis, and Future Directions
    Vittorio Stumpo, Lelio Guida, Jacopo Bellomo, Christiaan Hendrik Bas Van Niftrik, Martina Sebök, Moncef Berhouma, Andrea Bink, Michael Weller, Zsolt Kulcsar, Luca Regli, Jorn Fierstra
    Cancers 2022 14 5
  • Multiparametric Framework Magnetic Resonance Imaging Assessment of Subtypes of Intracranial Germ Cell Tumors Using Susceptibility Weighted Imaging, Diffusion‐Weighted Imaging, and Dynamic Susceptibility‐Contrast Perfusion‐Weighted Imaging Combined With Conventional Magnetic Resonance Imaging
    Yanong Li, Peng Wang, Jing Zhang, Jane Li, Li Chen, Xiaoguang Qiu
    Journal of Magnetic Resonance Imaging 2022 56 4
  • Diffusion-tensor imaging and dynamic susceptibility contrast MRIs improve radiomics-based machine learning model of MGMT promoter methylation status in glioblastomas
    Tran Nguyen Tuan Minh, Viet Huan Le, Nguyen Quoc Khanh Le
    Biomedical Signal Processing and Control 2023 86
  • Increased ASF1B Expression Correlates With Poor Prognosis in Patients With Gliomas
    Huaxin Zhu, Hengyang Ouyang, Xinyi Pan, Zhixiong Zhang, Jiacong Tan, Nianzu Yu, Meihua Li, Yeyu Zhao
    Frontiers in Oncology 2022 12
  • Adaptive fine-tuning based transfer learning for the identification of MGMT promoter methylation status
    Erich Schmitz, Yunhui Guo, Jing Wang
    Biomedical Physics & Engineering Express 2024 10 5

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