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Research ArticleAdult Brain

Traumatic Cerebral Microbleeds in the Subacute Phase Are Practical and Early Predictors of Abnormality of the Normal-Appearing White Matter in the Chronic Phase

A.W. van der Eerden, T.L. van den Heuvel, V. Perlbarg, P. Vart, P.E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing and B.M. Goraj
American Journal of Neuroradiology May 2021, 42 (5) 861-867; DOI: https://doi.org/10.3174/ajnr.A7028
A.W. van der Eerden
aFrom the Department of Radiology and Nuclear Medicine (A.W.v.d.E., T.L.v.d.H., B.P., R.M., B.M.G.), Radboud University Medical Center, Nijmegen, The Netherlands
bErasmus Medical Center, Department of Radiology & Nuclear Medicine (A.W.v.d.E.), Rotterdam, The Netherlands
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T.L. van den Heuvel
aFrom the Department of Radiology and Nuclear Medicine (A.W.v.d.E., T.L.v.d.H., B.P., R.M., B.M.G.), Radboud University Medical Center, Nijmegen, The Netherlands
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V. Perlbarg
cInserm, Sorbonne Université (V.P.), CNRS, Laboratoire d'Imagerie Biomédicale, Paris, France
dBrainTale SAS (V.P.), Paris, France
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P. Vart
eDepartment of Epidemiology and Biostatistics (P.V.), Radboud University Nijmegen, Nijmegen, The Netherlands
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P.E. Vos
fDepartment of Neurology (P.E.V.), Santiz-Slingeland Hospital, Doetinchem, The Netherlands
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L. Puybasset
gDepartment of Neurosurgical ICU (L.P.), Pitié Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
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D. Galanaud
hDepartment of Neuroradiology (D.G.), Pitié Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
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B. Platel
aFrom the Department of Radiology and Nuclear Medicine (A.W.v.d.E., T.L.v.d.H., B.P., R.M., B.M.G.), Radboud University Medical Center, Nijmegen, The Netherlands
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R. Manniesing
aFrom the Department of Radiology and Nuclear Medicine (A.W.v.d.E., T.L.v.d.H., B.P., R.M., B.M.G.), Radboud University Medical Center, Nijmegen, The Netherlands
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B.M. Goraj
aFrom the Department of Radiology and Nuclear Medicine (A.W.v.d.E., T.L.v.d.H., B.P., R.M., B.M.G.), Radboud University Medical Center, Nijmegen, The Netherlands
iDepartment of Diagnostic Imaging (B.M.G.), Medical Centre of Postgraduate Education, Warsaw, Poland
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References

  1. 1.↵
    1. Nguyen R,
    2. Fiest KM,
    3. McChesney J, et al
    . The international incidence of traumatic brain injury: a systematic review and meta-analysis. Can J Neurol Sci 2016;43:774–85 doi:10.1017/cjn.2016.290 pmid:27670907
    CrossRefPubMed
  2. 2.↵
    1. Peeters W,
    2. Van den Brande R,
    3. Polinder S, et al
    . Epidemiology of traumatic brain injury in Europe. Acta Neurochir (Wien) 2015;157:1683–96 doi:10.1007/s00701-015-2512-7 pmid:26269030
    CrossRefPubMed
  3. 3.↵
    1. Skandsen T,
    2. Kvistad KA,
    3. Solheim O, et al
    . Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: a cohort study of early magnetic resonance imaging findings and 1-year outcome. J Neurosurg 2010;113:556–63 doi:10.3171/2009.9.JNS09626
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Wallace EJ,
    2. Mathias JL,
    3. Ward L
    . The relationship between diffusion tensor imaging findings and cognitive outcomes following adult traumatic brain injury: a meta-analysis. Neurosci Biobehav Rev 2018;92:93–103 doi:10.1016/j.neubiorev.2018.05.023 pmid:29803527
    CrossRefPubMed
  5. 5.↵
    1. Hulkower MB,
    2. Poliak DB,
    3. Rosenbaum SB, et al
    . A decade of DTI in traumatic brain injury: 10 years and 100 articles later. AJNR Am J Neuroradiol 2013;34:2064–74 doi:10.3174/ajnr.A3395 pmid:23306011
    Abstract/FREE Full Text
  6. 6.↵
    1. Sidaros A,
    2. Engberg AW,
    3. Sidaros K, et al
    . Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2008;131:559–72 doi:10.1093/brain/awm294
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Haller S,
    2. Vernooij MW,
    3. Kuijer JPA, et al
    . Cerebral microbleeds: imaging and clinical significance. Radiology 2018;287:11–28 doi:10.1148/radiol.2018170803 pmid:29558307
    CrossRefPubMed
  8. 8.↵
    1. Shenton ME,
    2. Hamoda HM,
    3. Schneiderman JS, et al
    . A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav 2012;6:137–92 doi:10.1007/s11682-012-9156-5 pmid:22438191
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Ma C,
    2. Liu A,
    3. Li Z, et al
    . Longitudinal study of diffusion tensor imaging properties of affected cortical spinal tracts in acute and chronic hemorrhagic stroke. J Clin Neurosci 2014;21:1388–92 doi:10.1016/j.jocn.2013.11.032 pmid:24746110
    CrossRefPubMed
  10. 10.↵
    1. Yokoyama K,
    2. Matsuki M,
    3. Shimano H, et al
    . Diffusion tensor imaging in chronic subdural hematoma: correlation between clinical signs and fractional anisotropy in the pyramidal tract. AJNR Am J Neuroradiol 2008;29:1159–63 doi:10.3174/ajnr.A1001 pmid:18356470
    Abstract/FREE Full Text
  11. 11.↵
    1. Mac Donald CL,
    2. Dikranian K,
    3. Bayly P, et al
    . Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci 2007;27:11869–76 doi:10.1523/JNEUROSCI.3647-07.2007 pmid:17978027
    Abstract/FREE Full Text
  12. 12.↵
    1. Edlow BL,
    2. Copen WA,
    3. Izzy S, et al
    . Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis. BMC Neurol 2016;16 doi:10.1186/s12883-015-0525-8 pmid:6754948
    CrossRefPubMed
  13. 13.↵
    1. Perez AM,
    2. Adler J,
    3. Kulkarni N, et al
    . Longitudinal white matter changes after traumatic axonal injury. J Neurotrauma 2014;31:1478–85 doi:10.1089/neu.2013.3216
    CrossRef
  14. 14.↵
    1. Einarsen CE,
    2. Moen KG,
    3. Håberg AK, et al
    . Patients with mild traumatic brain injury recruited from both hospital and primary care settings: a controlled longitudinal magnetic resonance imaging study. J Neurotrauma 2019;36:3172–82 doi:10.1089/neu.2018.6360 pmid:31280698
    CrossRefPubMed
  15. 15.↵
    1. Toth A,
    2. Kovacs N,
    3. Tamas V, et al
    . Microbleeds may expand acutely after traumatic brain injury. Neurosci Lett 2016;617:207–12 doi:10.1016/j.neulet.2016.02.028 pmid:26912192
    CrossRefPubMed
  16. 16.↵
    1. Liu W,
    2. Soderlund K,
    3. Senseney JS, et al
    . Imaging cerebral microhemorrhages in military service members with chronic traumatic brain injury. Radiology 2016;278:536–45 doi:10.1148/radiol.2015150160 pmid:26371749
    CrossRefPubMed
  17. 17.↵
    1. Griffin AD,
    2. Turtzo LC,
    3. Parikh GY, et al
    . Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury. Brain 2019;142:3550–64 doi:10.1093/brain/awz290 pmid:31608359
    CrossRefPubMed
  18. 18.↵
    1. Benson RR,
    2. Gattu R,
    3. Sewick B, et al
    . Detection of hemorrhagic and axonal pathology in mild traumatic brain injury using advanced MRI: implications for neurorehabilitation. NeuroRehabilitation 2012;31:261–79 doi:10.3233/NRE-2012-0795 pmid:23093454
    CrossRefPubMed
  19. 19.↵
    1. Zhang J,
    2. Tao R,
    3. Liu C, et al
    . Possible effects of iron deposition on the measurement of DTI metrics in deep gray matter nuclei: an in vitro and in vivo study. Neurosci Lett 2013;551:47–52 doi:10.1016/j.neulet.2013.07.003 pmid:23872093
    CrossRefPubMed
  20. 20.↵
    1. Cicuendez M,
    2. Castaño-León A,
    3. Ramos A, et al
    . Prognostic value of corpus callosum injuries in severe head trauma. Acta Neurochir 2017;159:25–32 doi:10.1007/s00701-016-3000-4
    CrossRefPubMed
  21. 21.↵
    1. Wang JY,
    2. Abdi H,
    3. Bakhadirov K, et al
    . A comprehensive reliability assessment of quantitative diffusion tensor tractography. NeuroImage 2012;60:1127–38 doi:10.1016/j.neuroimage.2011.12.062 pmid:22227883
    CrossRefPubMed
  22. 22.↵
    1. Dennis EL,
    2. Ellis MU,
    3. Marion SD, et al
    . Callosal function in pediatric traumatic brain injury linked to disrupted white matter integrity. J Neurosci 2015;35:10202–11 doi:10.1523/JNEUROSCI.1595-15.2015 pmid:26180196
    Abstract/FREE Full Text
  23. 23.↵
    1. Domin M,
    2. Lotze M
    . Parcellation of motor cortex-associated regions in the human corpus callosum on the basis of Human Connectome Project data. Brain Struct Funct 2019;224:1447–55 doi:10.1007/s00429-019-01849-1 pmid:30778685
    CrossRefPubMed
  24. 24.↵
    1. Laouchedi M,
    2. Galanaud D,
    3. Delmaire C, et al
    . Deafferentation in thalamic and pontine areas in severe traumatic brain injury. J Neuroradiol 2015;42:202–11 doi:10.1016/j.neurad.2014.03.001 pmid:24997478
    CrossRefPubMed
  25. 25.↵
    1. Chen YJ,
    2. Nabavizadeh SA,
    3. Vossough A, et al
    . Wallerian degeneration beyond the corticospinal tracts: conventional and advanced MRI findings. J Neuroimaging 2017;27:272–80 doi:10.1111/jon.12404 pmid:28072502
    CrossRefPubMed
  26. 26.↵
    MNI ICBM 152 non-linear 6th Generation Symmetric Average Brain Stereotaxic Registration Model. http://nist.mni.mcgill.ca/?p=858. Accessed December 2017
  27. 27.↵
    1. Gregoire SM,
    2. Chaudhary UJ,
    3. Brown MM, et al
    . The Microbleed Anatomical Rating Scale (MARS): reliability of a tool to map brain microbleeds. Neurology 2009;73:1759–66 doi:10.1212/WNL.0b013e3181c34a7d
    CrossRefPubMed
  28. 28.↵
    1. Mori S,
    2. Oishi K,
    3. Jiang H, et al
    . Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 2008;40:570–82 doi:10.1016/j.neuroimage.2007.12.035 pmid:18255316
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Moen KG,
    2. Vik A,
    3. Olsen A, et al
    . Traumatic axonal injury: relationships between lesions in the early phase and diffusion tensor imaging parameters in the chronic phase of traumatic brain injury. J Neurosci Res 2016;94:623–35 doi:10.1002/jnr.23728 pmid:26948154
    CrossRefPubMed
  30. 30.↵
    1. Toth A,
    2. Kornyei B,
    3. Kovacs N, et al
    . Both hemorrhagic and non-hemorrhagic traumatic MRI lesions are associated with the microstructural damage of the normal appearing white matter. Behav Brain Res 2018;340:106–16 doi:10.1016/j.bbr.2017.02.039 pmid:28249729
    CrossRefPubMed
  31. 31.↵
    1. Kumar R,
    2. Husain M,
    3. Gupta RK, et al
    . Serial changes in the white matter diffusion tensor imaging metrics in moderate traumatic brain injury and correlation with neuro-cognitive function. J Neurotrauma 2009;26:481–95 doi:10.1089/neu.2008.0461 pmid:19196176
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Keene CD,
    2. Latimer CS,
    3. Steele LM, et al
    . First confirmed case of chronic traumatic encephalopathy in a professional bull rider. Acta Neuropathol 2018;135:303–05 doi:10.1007/s00401-017-1801-z pmid:29285625
    CrossRefPubMed
  33. 33.↵
    1. Adams JH,
    2. Graham DI,
    3. Murray LS, et al
    . Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann Neurol 1982;12:557–63 doi:10.1002/ana.410120610 pmid:7159059
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. McKee AC,
    2. Stein TD,
    3. Nowinski CJ, et al
    . The spectrum of disease in chronic traumatic encephalopathy. Brain 2013;136:43–64 doi:10.1093/brain/aws307 pmid:23208308
    CrossRefPubMedWeb of Science
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A.W. van der Eerden, T.L. van den Heuvel, V. Perlbarg, P. Vart, P.E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing, B.M. Goraj
Traumatic Cerebral Microbleeds in the Subacute Phase Are Practical and Early Predictors of Abnormality of the Normal-Appearing White Matter in the Chronic Phase
American Journal of Neuroradiology May 2021, 42 (5) 861-867; DOI: 10.3174/ajnr.A7028

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Traumatic Cerebral Microbleeds in the Subacute Phase Are Practical and Early Predictors of Abnormality of the Normal-Appearing White Matter in the Chronic Phase
A.W. van der Eerden, T.L. van den Heuvel, V. Perlbarg, P. Vart, P.E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing, B.M. Goraj
American Journal of Neuroradiology May 2021, 42 (5) 861-867; DOI: 10.3174/ajnr.A7028
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