Article Figures & Data
Figures
- FIG 1.
BOLD asynchrony decreases with distance from the tumor. A, Exponential fits were made to BOLD asynchrony values across all voxels within a 3-cm radius as a function of distance from the tumor for each patient. Blue lines represent individual patients with low-grade tumors; red lines represent individual patients with high-grade tumors. B, The mean BOLD asynchrony is greater for high-grade than low-grade tumors at comparable distances from the tumor. Shading represents standard error of the mean. C, Bars represent the median spatial decay for the low- (blue) and high-grade (red) tumors; dots represent decay constants for individual patients. High-grade meningiomas have significantly slower spatial decay rates, indicating that high-grade tumors caused a larger disruption to surrounding vasculature. D–F, FLAIR signal did not differ significantly between groups. Note, the error bars are very large and extend beyond the visible range.
- FIG 2.
Representative axial slices from a 77-year-old male patient (A) with a grade I meningioma and a 75-year-old male patient (B) with a grade II meningioma. The first 3 columns show the T1-weighted postcontrast image, the T2-FLAIR, and the T2-FLAIR with overlaid masks representing the contrast enhancement (green) and the T2-FLAIR hyperintensity outside the tumor (white). The fourth and fifth columns show the BOLD asynchrony map and the BOLD asynchrony map with overlaid masks representing the contrast enhancement (green) and the BOLD asynchrony outside the tumor (white). The high-grade tumor (B) has BOLD asynchrony extending further outside the region of contrast enhancement than the low-grade tumor.
- FIG 3.
Boxplots demonstrate that high-grade meningiomas are characterized by greater BOF values than low-grade meningiomas (A). B, FOF values were higher in high-grade meningiomas, though this did not reach significance. Receiver operating characteristic curves for BOF show high discriminability for grade (C), while FOF demonstrates marginal discriminability (D).
- FIG 4.
A, The weighted mean of BOF and FOF shows a difference comparable with the BOF alone. B, The discriminability of the weighted model is better, though only marginally, than the BOF alone.
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