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Research ArticleAdult Brain
Open Access

Quantifying T2-FLAIR Mismatch Using Geographically Weighted Regression and Predicting Molecular Status in Lower-Grade Gliomas

S. Mohammed, V. Ravikumar, E. Warner, S.H. Patel, S. Bakas, A. Rao and R. Jain
American Journal of Neuroradiology January 2022, 43 (1) 33-39; DOI: https://doi.org/10.3174/ajnr.A7341
S. Mohammed
aFrom the Departments of Biostatistics (S.M., A.R.)
bComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.)
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V. Ravikumar
bComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.)
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E. Warner
bComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.)
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S.H. Patel
fDepartment of Radiology & Medical Imaging (S.H.P.), University of Virginia School of Medicine, Charlottesville, Virginia
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S. Bakas
gDepartments of Radiology (S.B.)
hPathology & Laboratory Medicine (S.B.), University of Pennsylvania, Philadelphia, Pennsylvania
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A. Rao
aFrom the Departments of Biostatistics (S.M., A.R.)
bComputational Medicine & Bioinformatics (S.M., V.R., E.W., A.R.)
cRadiation Oncology (A.R.)
dMichigan Institute for Data Sciences (A.R.)
eDepartment of Biomedical Engineering (A.R.), University of Michigan, Ann Arbor, Michigan
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R. Jain
iDepartments of Radiology (R.J.)
jNeurosurgery (R.J.), New York University Grossman School of Medicine, New York, New York
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References

  1. 1.↵
    1. Claus EB,
    2. Walsh KM,
    3. Wiencke JK, et al
    . Survival and low-grade glioma: the emergence of genetic information. Neurosurg Focus 2015;38:E6 doi:10.3171/2014.10.FOCUS12367 pmid:25552286
    CrossRefPubMed
  2. 2.↵
    1. Wesseling P,
    2. Capper D
    . WHO 2016 classification of gliomas. Neuropathol Appl Neurobiol 2018;44:139–50 doi:10.1111/nan.12432 pmid:28815663
    CrossRefPubMed
  3. 3.↵
    1. Ho VKY,
    2. Reijneveld JC,
    3. Enting RH, et al
    . Changing incidence and improved survival of gliomas. Eur J Cancer 2014;50:2309–18 doi:10.1016/j.ejca.2014.05.019 pmid:24972545
    CrossRefPubMed
  4. 4.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  5. 5.↵
    1. Brat DJ,
    2. Verhaak GW,
    3. Aldape KD
    , et al. Cancer Genome Atlas Research Network. Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas. N Engl J Med 2015;372:2481–98 doi:10.1056/NEJMoa1402121 pmid:26061751
    CrossRefPubMed
  6. 6.↵
    1. Patel SH,
    2. Poisson LM,
    3. Brat DJ, et al
    . T2-FLAIR mismatch, an imaging biomarker for IDH and 1p/19q status in lower-grade gliomas: a TCGA/TCIA project. Clin Cancer Res 2017;23:6078–85 doi:10.1158/1078-0432.CCR-17-0560 pmid:28751449
    Abstract/FREE Full Text
  7. 7.↵
    1. Broen MP,
    2. Smits M,
    3. Wijnenga MM, et al
    . The T2-FLAIR mismatch sign as an imaging marker for non-enhancing IDH-mutant, 1p/19q-intact lower-grade glioma: a validation study. Neuro Oncol 2018;20:1393–99 doi:10.1093/neuonc/noy048 pmid:29590424
    CrossRefPubMed
  8. 8.↵
    1. Jain R,
    2. Johnson DR,
    3. Patel SH, et al
    . “Real world” use of a highly reliable imaging sign: “T2-FLAIR mismatch” for identification of IDH mutant astrocytomas. Neuro Oncol 2020;22:936–43 doi:10.1093/neuonc/noaa041 pmid:32064507
    CrossRefPubMed
  9. 9.↵
    1. Lasocki A,
    2. Gaillard F,
    3. Gorelik A, et al
    . MRI features can predict 1p/19q status in intracranial gliomas. AJNR Am J Neuroradiol 2018;39:687–92 doi:10.3174/ajnr.A5572 pmid:29519793
    Abstract/FREE Full Text
  10. 10.↵
    1. Niemeyer B,
    2. Muniz B,
    3. Marchiori E
    . T2-FLAIR mismatch sign as an imaging biomarker in lower-grade gliomas. Eur Neurol 2018;79:317–18 doi:10.1159/000490709 pmid:29986339
    CrossRefPubMed
  11. 11.↵
    1. Batchala PP,
    2. Muttikkal TJE,
    3. Donahue JH, et al
    . Neuroimaging-based classification algorithm for predicting 1p/19q-codeletion status in IDH-mutant lower-grade gliomas. AJNR Am J Neuroradiol 2019;40:426–32 doi:10.3174/ajnr.A5957 pmid:30705071
    Abstract/FREE Full Text
  12. 12.↵
    1. Johnson DR,
    2. Kaufmann TJ,
    3. Patel SH, et al
    . There is an exception to every rule: T2-FLAIR mismatch sign in gliomas. Neuroradiology 2019;61:225–27 doi:10.1007/s00234-018-2148-4 pmid:30565056
    CrossRefPubMed
  13. 13.↵
    1. Juratli TA,
    2. Tummala SS,
    3. Riedl A, et al
    . Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower-grade gliomas: correlation with molecular groups. J Neurooncol 2019;141:327–35 doi:10.1007/s11060-018-03034-6 pmid:30536195
    CrossRefPubMed
  14. 14.↵
    1. Foltyn M,
    2. Taborda KN,
    3. Neuberger U, et al
    . T2/FLAIR-mismatch sign for noninvasive detection of IDH-mutant 1p/19q non-codeleted gliomas: validity and pathophysiology. Neurooncol Adv 2020;2:vdaa004 doi:10.1093/noajnl/vdaa004 pmid:3264675
    CrossRefPubMed
  15. 15.↵
    1. Aliotta E,
    2. Dutta SW,
    3. Feng X, et al
    . Automated apparent diffusion coefficient analysis for genotype prediction in lower-grade glioma: association with the T2-FLAIR mismatch sign. J Neurooncol 2020;149:325–35 doi:10.1007/s11060-020-03611-8 pmid:32909115
    CrossRefPubMed
  16. 16.↵
    1. Brunsdon C,
    2. Fotheringham AS,
    3. Charlton ME
    . Geographically weighted regression: a method for exploring spatial nonstationarity. Geographical Analysis 2010;28:281–98 doi:10.1111/j.1538-4632.1996.tb00936.x
    CrossRef
  17. 17.↵
    1. Mohammed S,
    2. Li T,
    3. Chen XD, et al
    . Density-based classification in diabetic retinopathy through thickness of retinal layers from optical coherence tomography. Sci Rep 2020;10:1–13 doi:10.1038/s41598-019-56847-4 pmid:31913322
    CrossRefPubMed
  18. 18.↵
    1. Grohs P,
    2. Holler M,
    3. Weinmann A
    1. Matuk J,
    2. Mohammed S,
    3. Kurtek S, et al
    . Biomedical applications of geometric functional data analysis. In: Grohs P, Holler M, Weinmann A. Handbook of Variational Methods for Nonlinear Geometric Data. Springer-Verlag; 2020:675–701
  19. 19.↵
    1. Clark K,
    2. Vendt B,
    3. Smith K, et al
    . The Cancer Imaging Archive (TCIA): maintaining and operating a public information repository. J Digit Imaging 2013;26:1045–57 doi:10.1007/s10278-013-9622-7 pmid:23884657
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Bakas S,
    2. Akbari H,
    3. Sotiras A, et al
    . Advancing the Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features. Sci Data 2017;4:170117 doi:10.1038/sdata.2017.117 pmid:28872634
    CrossRefPubMed
  21. 21.↵
    1. Bakas S,
    2. Akbari H,
    3. Sotiras A, et al
    . Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection [BraTS-TCGA-LCC]. Cancer Imaging Archive 2017 doi:10.7937/K9/TCIA.2017.GJQ7R0EF
    CrossRef
  22. 22.↵
    1. Ceccarelli M,
    2. Barthel FP,
    3. Malta TM, et al
    ; TCGA Research Network. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 2016;164:550–63 doi:10.1016/j.cell.2015.12.028 pmid:26824661
    CrossRefPubMed
  23. 23.↵
    1. Shinohara RT,
    2. Sweeney EM,
    3. Goldsmith J, et al
    . Statistical normalization techniques for magnetic resonance imaging. Neuroimage Clin 2014;6:9–19 doi:10.1016/j.nicl.2014.08.008 pmid:25379412
    CrossRefPubMed
  24. 24.↵
    1. Klassen EP,
    2. Srivastava A
    . Functional and Shape Data Analysis. Springer-Verlag; 2016
  25. 25.↵
    1. Bhattacharyya A
    . On a measure of divergence between two statistical populations defined by their probability distributions. Bulletin of the Calcutta Mathematical Society 1943;35:99–109
  26. 26.↵
    1. DeLong ER,
    2. DeLong DM,
    3. Clarke-Pearson DL
    . Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988;44:837–45 doi:10.2307/2531595 pmid:3203132
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Robin X,
    2. Turck N,
    3. Hainard A, et al
    . pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 2011;12:77 doi:10.1186/1471-2105-12-77 pmid:21414208
    CrossRefPubMed
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American Journal of Neuroradiology: 43 (1)
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S. Mohammed, V. Ravikumar, E. Warner, S.H. Patel, S. Bakas, A. Rao, R. Jain
Quantifying T2-FLAIR Mismatch Using Geographically Weighted Regression and Predicting Molecular Status in Lower-Grade Gliomas
American Journal of Neuroradiology Jan 2022, 43 (1) 33-39; DOI: 10.3174/ajnr.A7341

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Quantifying T2-FLAIR Mismatch Using Geographically Weighted Regression and Predicting Molecular Status in Lower-Grade Gliomas
S. Mohammed, V. Ravikumar, E. Warner, S.H. Patel, S. Bakas, A. Rao, R. Jain
American Journal of Neuroradiology Jan 2022, 43 (1) 33-39; DOI: 10.3174/ajnr.A7341
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