Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Getting new auth cookie, if you see this message a lot, tell someone!
Research ArticlePediatric Neuroimaging

Asymmetry Matters: Diffusion Tensor Tractography of the Uncinate Fasciculus in Children with Verbal Memory Deficits

S.A. Mohammad, N.H. Nashaat, A.A.M.B. Okba, A. Kilany, A.S. Abdel-Rahman, A.M. Abd-Elhamed and E.R. Abdelraouf
American Journal of Neuroradiology July 2022, 43 (7) 1042-1047; DOI: https://doi.org/10.3174/ajnr.A7535
S.A. Mohammad
aFrom the Department of Diagnostic and Interventional Radiology and Molecular Imaging (S.A.M., A.A.M.B.O., A.S.A.-R., A.M.A.-E.), Faculty of Medicine, Ain Shams University, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.A. Mohammad
N.H. Nashaat
bResearch on Children with Special Needs Department (N.H.N., A.K., E.R.A.), Medical Research Division, National Research Centre, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N.H. Nashaat
A.A.M.B. Okba
aFrom the Department of Diagnostic and Interventional Radiology and Molecular Imaging (S.A.M., A.A.M.B.O., A.S.A.-R., A.M.A.-E.), Faculty of Medicine, Ain Shams University, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.A.M.B. Okba
A. Kilany
bResearch on Children with Special Needs Department (N.H.N., A.K., E.R.A.), Medical Research Division, National Research Centre, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Kilany
A.S. Abdel-Rahman
aFrom the Department of Diagnostic and Interventional Radiology and Molecular Imaging (S.A.M., A.A.M.B.O., A.S.A.-R., A.M.A.-E.), Faculty of Medicine, Ain Shams University, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.S. Abdel-Rahman
A.M. Abd-Elhamed
aFrom the Department of Diagnostic and Interventional Radiology and Molecular Imaging (S.A.M., A.A.M.B.O., A.S.A.-R., A.M.A.-E.), Faculty of Medicine, Ain Shams University, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.M. Abd-Elhamed
E.R. Abdelraouf
bResearch on Children with Special Needs Department (N.H.N., A.K., E.R.A.), Medical Research Division, National Research Centre, Cairo, Egypt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E.R. Abdelraouf
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Brem AK,
    2. Ran K,
    3. Pascual-Leone A
    . Learning and memory. Handb Clin Neurol 2013;116:693–737 doi:10.1016/B978-0-444-53497-2.00055-3 pmid:24112934
    CrossRefPubMed
  2. 2.↵
    1. Bauer PJ,
    2. Blue SN,
    3. Xu A, et al
    . Productive extension of semantic memory in school-aged children: relations with reading comprehension and deployment of cognitive resources. Dev Psychol 2016;52:1024–37 doi:10.1037/dev0000130 pmid:27253263
    CrossRefPubMed
  3. 3.↵
    1. Nashaat N,
    2. Hasan H,
    3. Kilany A, et al
    . Correlation between reading and spelling performance of Egyptian children with reading disorder and their cognitive and linguistic abilities. Journal of Indian Association for Child and Adolescent Mental Health 2017;13:82–106
    CrossRef
  4. 4.↵
    1. Thompson RF,
    2. Kim JJ
    . Memory systems in the brain and localization of a memory. Proc Natl Acad Sci U S A 1996;93:13438–44 doi:10.1073/pnas.93.24.13438 pmid:8942954
    Abstract/FREE Full Text
  5. 5.↵
    1. Kelley WM,
    2. Miezin FM,
    3. McDermott KB, et al
    . Hemispheric specialization in human dorsal frontal cortex and medial temporal lobe for verbal and nonverbal memory encoding. Neuron 1998;20:927–36 doi:10.1016/s0896-6273(00)80474-2 pmid:9620697
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Gotts SJ,
    2. Jo HJ,
    3. Wallace GL, et al
    . Two distinct forms of functional lateralization in the human brain. Proc Natl Acad Sci U S A 2013;110:E3435–44 doi:10.1073/pnas.1302581110 pmid:23959883
    Abstract/FREE Full Text
  7. 7.↵
    1. Menon V,
    2. Boyett-Anderson JM,
    3. Reiss AL
    . Maturation of medial temporal lobe response and connectivity during memory encoding. Brain Res Cogn Brain Res 2005;25:379–85 doi:10.1016/j.cogbrainres.2005.07.007 pmid:16122916
    CrossRefPubMed
  8. 8.↵
    1. Kubicki M,
    2. Westin CF,
    3. Maier SE, et al
    . Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. Am J Psychiatry 2002;159:813–20 doi:10.1176/appi.ajp.159.5.813 pmid:11986136
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Mohammad SA,
    2. Sakr HM,
    3. Bondok SM, et al
    . Fronto-temporal connectivity in never-medicated patients with first-episode schizophrenia: a DTI study. Egypt Journal of Radiology and Nuclear Medicine 2016;47:255–62 doi:10.1016/j.ejrnm.2015.11.012
    CrossRef
  10. 10.↵
    1. Song JW,
    2. Mitchell PD,
    3. Kolasinski J, et al
    . Asymmetry of white matter pathways in developing human brains. Cereb Cortex 2015;25:2883–93 doi:10.1093/cercor/bhu084 pmid:24812082
    CrossRefPubMed
  11. 11.↵
    1. Carper RA,
    2. Treiber JM,
    3. DeJesus SY, et al
    . Reduced hemispheric asymmetry of white matter microstructure in autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 2016;55:1073–80 doi:10.1016/j.jaac.2016.09.491 pmid:27871642
    CrossRefPubMed
  12. 12.↵
    1. Zhao X,
    2. Zhou ZQ,
    3. Xiong Y, et al
    . Reduced interhemispheric white matter asymmetries in medial temporal lobe epilepsy with hippocampal sclerosis. Front Neurol 2019;10:394 doi:10.3389/fneur.2019.00394 pmid:31068889
    CrossRefPubMed
  13. 13.↵
    1. Powell HW,
    2. Parker GJ,
    3. Alexander DC, et al
    . Hemispheric asymmetries in language-related pathways: a combined functional MRI and tractography study. Neuroimage 2006;32:388–99 doi:10.1016/j.neuroimage.2006.03.011 pmid:16632380
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Hasan KM,
    2. Iftikhar A,
    3. Kamali A, et al
    . Development and aging of the healthy human brain uncinate fasciculus across the lifespan using diffusion tensor tractography. Brain Res 2009;1276:67–76 doi:10.1016/j.brainres.2009.04.025 pmid:19393229
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Von Der Heide RJ,
    2. Skipper LM,
    3. Klobusicky E, et al
    . Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis. Brain 2013;136:1692–1707 doi:10.1093/brain/awt094 pmid:23649697
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Mohammad SA,
    2. Nashaat NH
    . Age-related changes of white matter association tracts in normal children throughout adulthood: a diffusion tensor tractography study. Neuroradiology 2017;59:715–24 doi:10.1007/s00234-017-1858-3 pmid:28580531
    CrossRefPubMed
  17. 17.↵
    1. Peters BD,
    2. Szeszko PR,
    3. Radua J, et al
    . White matter development in adolescence: diffusion tensor imaging and meta-analytic results. Schizophr Bull 2012;38:1308–17 doi:10.1093/schbul/sbs054 pmid:22499780
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. Schaeffer DJ,
    2. Krafft CE,
    3. Schwarz NF, et al
    . The relationship between uncinate fasciculus white matter integrity and verbal memory proficiency in children. Neuroreport 20142;25:921–25 doi:10.1097/WNR.0000000000000204 pmid:24949818
    CrossRefPubMed
  19. 19.↵
    1. Mabbott DJ,
    2. Rovet J,
    3. Noseworthy MD, et al
    . The relations between white matter and declarative memory in older children and adolescents. Brain Res 2009;1294:80–90 doi:10.1016/j.brainres.2009.07.046 pmid:19632208
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Eluvathingal TJ,
    2. Hasan KM,
    3. Kramer L, et al
    . Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents. Cereb Cortex 2007;17:2760–68 doi:10.1093/cercor/bhm003 pmid:17307759
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Diehl B,
    2. Busch RM,
    3. Duncan JS, et al
    . Abnormalities in diffusion tensor imaging of the uncinate fasciculus relate to reduced memory in temporal lobe epilepsy. Epilepsia 2008;49:1409–18 doi:10.1111/j.1528-1167.2008.01596.x pmid:18397294
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Chung S,
    2. Wang X,
    3. Fieremans E, et al
    . Altered relationship between working memory and brain microstructure after mild traumatic brain injury. AJNR Am J Neuroradiol 2019;40:1438–44 doi:10.3174/ajnr.A6146 pmid:31371359
    Abstract/FREE Full Text
  23. 23.↵
    1. Matsuo K,
    2. Mizuno T,
    3. Yamada K, et al
    . Cerebral white matter damage in frontotemporal dementia assessed by diffusion tensor tractography. Neuroradiology 2008;50:605–11 doi:10.1007/s00234-008-0379-5 pmid:18379765
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Cortiella C,
    2. Horowitz SH
    . The state of learning disabilities: facts, trends, and emerging issues. August 13 2014. https://www.ncld.org/wp-content/uploads/2014/11/2014-State-of-LD.pdf. Accessed March 1, 2022
  25. 25.↵
    1. Melika L
    . Stanford Binet Intelligence Scale. 4th Arabic Version. 2nd ed. Victor Kiorlos Publishing, Cairo; 1998
  26. 26.↵
    1. Aboras Y,
    2. Abdou R,
    3. Kozou H
    . Development of an Arabic test for assessment of dyslexia in Egyptian children. Bull Alexandria Fac Med 2008;44:653–62
  27. 27.↵
    1. El-Sady S,
    2. El-Shobary A,
    3. Rifaie N
    , et al. Illinois Test of Psycholinguistic Abilities. [master's thesis]. Ain Shams University, Department of Otorhinolaryngology, Phoniatrics Unit; 1996
  28. 28.↵
    1. Jiang DT,
    2. van Zijl PC,
    3. Kim J, et al
    . DtiStudio: resource program for diffusion tensor computation and fiber bundle tracking. Comput Methods Programs Biomed 2006;81:106–16 doi:10.1016/j.cmpb.2005.08.004 pmid:16413083
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Wakana S,
    2. Caprihan A,
    3. Panzenboeck MM, et al
    . Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 2007;36:630–44 doi:10.1016/j.neuroimage.2007.02.049 pmid:17481925
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Martin-Ordas G,
    2. Atance CM,
    3. Caza JS
    . How do episodic and semantic memory contribute to episodic foresight in young children? Front Psychol 2004;5:732 doi:10.3389/fpsyg.2014.00732 pmid:25071690
    CrossRefPubMed
  31. 31.↵
    1. Papagno C
    . Naming and the role of the uncinate fasciculus in language function. Curr Neurol Neurosci Rep 2011;11:553–59 doi:10.1007/s11910-011-0219-6 pmid:21853238
    CrossRefPubMed
  32. 32.↵
    1. Papagno C,
    2. Miracapillo C,
    3. Casarotti A, et al
    . What is the role of the uncinate fasciculus? Surgical removal and proper name retrieval. Brain 2011;134:405–14 doi:10.1093/brain/awq283 pmid:20959310
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Park HJ,
    2. Westin CF,
    3. Kubicki M, et al
    . White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. Neuroimage 2004;23:213–23 doi:10.1016/j.neuroimage.2004.04.036 pmid:15325368
    CrossRefPubMedWeb of Science
  34. 34.↵
    1. Song SK,
    2. Sun SW,
    3. Ramsbottom MJ, et al
    . Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36 doi:10.1006/nimg.2002.1267 pmid:12414282
    CrossRefPubMedWeb of Science
  35. 35.↵
    1. Wada JA,
    2. Clarke R,
    3. Hamm A
    . Cerebral hemispheric asymmetry in humans: cortical speech zones in 100 adults and 100 infant brains. Arch Neurol 1975;32:239–46 doi:10.1001/archneur.1975.00490460055007 pmid:1124988
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Crow TJ,
    2. Ball J,
    3. Bloom SR, et al
    . Schizophrenia as an anomaly of development of cerebral asymmetry: a postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry 1989;46:1145–50 doi:10.1001/archpsyc.1989.01810120087013 pmid:2589928
    CrossRefPubMedWeb of Science
  37. 37.↵
    1. O'Regan L,
    2. Serrien DJ
    . Individual differences and hemispheric asymmetries for language and spatial attention. Front Hum Neurosci 2018;12:380 doi:10.3389/fnhum.2018.00380 pmid:30337864
    CrossRefPubMed
  38. 38.↵
    1. Waldie KE,
    2. Haigh CE,
    3. Badzakova-Trajkov G, et al
    . Reading the wrong way with the right hemisphere. Brain Sci 2013;3:1060–75 doi:10.3390/brainsci3031060 pmid:24961521
    CrossRefPubMed
  39. 39.↵
    1. Hoeft F,
    2. Barnea-Goraly N,
    3. Haas BW
    , et al. More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. J Neurosci 2007;27:11960–65 doi:10.1523/JNEUROSCI.3591-07.2007 pmid:17978036
    Abstract/FREE Full Text
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Asymmetry Matters: Diffusion Tensor Tractography of the Uncinate Fasciculus in Children with Verbal Memory Deficits
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
S.A. Mohammad, N.H. Nashaat, A.A.M.B. Okba, A. Kilany, A.S. Abdel-Rahman, A.M. Abd-Elhamed, E.R. Abdelraouf
Asymmetry Matters: Diffusion Tensor Tractography of the Uncinate Fasciculus in Children with Verbal Memory Deficits
American Journal of Neuroradiology Jul 2022, 43 (7) 1042-1047; DOI: 10.3174/ajnr.A7535

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Asymmetric Uncinate Fasciculus for Memory Deficits
S.A. Mohammad, N.H. Nashaat, A.A.M.B. Okba, A. Kilany, A.S. Abdel-Rahman, A.M. Abd-Elhamed, E.R. Abdelraouf
American Journal of Neuroradiology Jul 2022, 43 (7) 1042-1047; DOI: 10.3174/ajnr.A7535
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref (1)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Neuroimaging Findings for the Overnight Consolidation of Learned Non-native Speech Sounds
    F. Sayako Earle, Peter J. Molfese, Emily B. Myers
    Neurobiology of Language 2025 6

More in this TOC Section

  • Neuroimaging Delineation and Progression of SLSMD
  • New CNS Embryonal Tumor Insights via MRI Analysis
  • Reversible Perfusion Changes in GLUT-1 Deficiency
Show more PEDIATRIC NEUROIMAGING

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire