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MRI Monitoring of Anti-Alzheimer Therapy Amyloid-Related Imaging Abnormalities: Due Diligence or Overkill?

P.F. Høilund-Carlsen, A. Alavi, G. Perry and J.R. Barrio
American Journal of Neuroradiology January 2023, 44 (1) E4-E5; DOI: https://doi.org/10.3174/ajnr.A7702
P.F. Høilund-Carlsen
aDepartment of Clinical ResearchUniversity of Southern DenmarkOdense, Denmark
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A. Alavi
bDepartment of RadiologyPerelman School of MedicineUniversity of PennsylvaniaPhiladelphia, Pennsylvania
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G. Perry
cDepartment of Neuroscience, Developmental and Regenerative BiologyUniversity of Texas at San AntonioSan Antonio, Texas
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J.R. Barrio
dDavid Geffen UCLA School of Medicine at UCLALos Angeles, California
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References

  1. 1.↵
    1. Cogswell PM,
    2. Barakos JA,
    3. Barkhof F, et al
    . Amyloid-related imaging abnormalities with emerging Alzheimer disease therapeutics: detection and reporting recommendations for clinical practice. AJNR Am J Neuroradiol 2022;43:E19–35 doi:10.3174/ajnr.A7586 pmid:35953274
    Abstract/FREE Full Text
  2. 2.↵
    1. Sevigny J,
    2. Chiao P,
    3. Bussière T, et al
    . The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature 2016;537:50–56 doi:10.1038/nature19323 pmid:27582220
    CrossRefPubMed
  3. 3.↵
    1. Klein G,
    2. Delmar P,
    3. Voyle N, et al
    . Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis. Alzheimers Res Ther 2019;11:101 doi:10.1186/s13195-019-0559-z pmid:31831056
    CrossRefPubMed
  4. 4.↵
    1. Høilund-Carlsen PF,
    2. Alavi A
    . Aducanumab (marketed as Aduhelm) approval is likely based on misinterpretation of PET imaging data. J Alzheimers Dis 2021;84:1457–60 doi:10.3233/JAD-215275 pmid:34657891
    CrossRefPubMed
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American Journal of Neuroradiology: 44 (1)
American Journal of Neuroradiology
Vol. 44, Issue 1
1 Jan 2023
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P.F. Høilund-Carlsen, A. Alavi, G. Perry, J.R. Barrio
MRI Monitoring of Anti-Alzheimer Therapy Amyloid-Related Imaging Abnormalities: Due Diligence or Overkill?
American Journal of Neuroradiology Jan 2023, 44 (1) E4-E5; DOI: 10.3174/ajnr.A7702

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MRI Monitoring of Anti-Alzheimer Therapy Amyloid-Related Imaging Abnormalities: Due Diligence or Overkill?
P.F. Høilund-Carlsen, A. Alavi, G. Perry, J.R. Barrio
American Journal of Neuroradiology Jan 2023, 44 (1) E4-E5; DOI: 10.3174/ajnr.A7702
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