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As chondrosarcoma and synovial chondromatosis of the temporomandibular joint share overlapping clinical and histopathologic features, CT and MR imaging can be helpful to differentiate between the 2 entities. High-risk imaging features for chondrosarcoma include the following: lesion centered on the mandibular condyle, destruction of the mandibular condyle, no destruction/sclerosis of the articular eminence/glenoid fossa, infiltration into the tendon of the lateral pterygoid muscle, absent or stippled calcification, periosteal reaction, internal enhancement, and size of ≥30.5 mm.