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Review ArticlePediatric Neuroimaging

International Consensus Statement on the Radiologic Evaluation of Dysraphic Malformations of the Spine and Spinal Cord

Ankit Balani, Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Özgür Öztekin, Valeria Capra, Martin Catala, Andrew J. Copp, Neetu Kumar, Navroop Johal, M. Zubair Tahir, Dominic Thompson, Dachling Pang, David M. Mirsky, Mai-Lan Ho, Thierry A.G.M. Huisman, Andrea Rossi and Kshitij Mankad
American Journal of Neuroradiology June 2024, 45 (6) 673-680; DOI: https://doi.org/10.3174/ajnr.A8117
Ankit Balani
aFrom the Department of Neuroradiology (A. Balani, J.S., S.S., A. Biswas, K.M.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Jai Sidpra
aFrom the Department of Neuroradiology (A. Balani, J.S., S.S., A. Biswas, K.M.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
bDevelopmental Biology and Cancer Section (J.S., A.J.C., K.M.), University College London Great Ormond Street Institute of Child Health, London, UK
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Sniya Sudhakar
aFrom the Department of Neuroradiology (A. Balani, J.S., S.S., A. Biswas, K.M.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Asthik Biswas
aFrom the Department of Neuroradiology (A. Balani, J.S., S.S., A. Biswas, K.M.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Özgür Öztekin
cDepartment of Neuroradiology (Ö.Ö.), Izmir Bakircay University, Izmir, Turkey
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Valeria Capra
dMedical Genetics Unit (V.C.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
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Martin Catala
eLaboratoire de Biologie du Développement (M.C.), UMR 7622 de Sorbonne Université et du CNRS, ERL 1156 de l’INSERM et Institut de Biologie Paris Seine, Paris, France
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Andrew J. Copp
bDevelopmental Biology and Cancer Section (J.S., A.J.C., K.M.), University College London Great Ormond Street Institute of Child Health, London, UK
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Neetu Kumar
fDepartment of Urology (N.K., N.J.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Navroop Johal
fDepartment of Urology (N.K., N.J.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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M. Zubair Tahir
gDepartment of Neurosurgery (M.Z.T., D.T., D.P.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Dominic Thompson
gDepartment of Neurosurgery (M.Z.T., D.T., D.P.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
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Dachling Pang
gDepartment of Neurosurgery (M.Z.T., D.T., D.P.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
hDepartment of Paediatric Neurosurgery (D.P.), University of California, Davis, Davis, California
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David M. Mirsky
iDepartment of Radiology (D.M.M.), Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado
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Mai-Lan Ho
jDepartment of Radiology (M.-L.H.), Nationwide Children’s Hospital, Ohio State University, Columbus, Ohio
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Thierry A.G.M. Huisman
kEdward B. Singleton Department of Radiology (T.A.G.M.H.), Texas Children’s Hospital and Baylor College of Medicine, Houston, Texas
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Andrea Rossi
lNeuroradiology Unit (A.R.), IRCCS Istituto Giannina Gaslini, Genoa, Italy
mDepartment of Health Sciences (A.R.), University of Genoa, Genoa, Italy
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Kshitij Mankad
aFrom the Department of Neuroradiology (A. Balani, J.S., S.S., A. Biswas, K.M.), Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
bDevelopmental Biology and Cancer Section (J.S., A.J.C., K.M.), University College London Great Ormond Street Institute of Child Health, London, UK
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    Table 1:

    Recommended MR imaging sequences and parameters for the assessment of children with suspected DMSSC

    SequencePlaneImaging ParametersNotes
    Essential sequences
     3 plane scout/localizerAxial, sagittal, coronalFor subsequent planning
     T1-weighted TSE whole spineSagittal3.0 mm thickness (TR, 600 ms, TE, 30 ms)—
     T2-weighted TSE whole spineSagittal3.0 mm thickness (TR, 3000 ms, TE, 120 ms)—
     T2-weighted FS, Dixon, or STIRCoronal3.0 mm thickness (TR, 3000 ms, TE, 40 ms)FS preferred over STIR; whole spine
     T1-weighted TSEAxial≤3.0 mm thicknessLumbosacral region (conus and filum terminale) and the suspected area of abnormality (group of axial images through the disc level not applied)
     T2-weighted DRIVE, CISS, or FIESTASagittal0.6 mm thicknessSagittal acquisition centered on the area of suspected abnormality with 3D reconstructions
    Optional sequences
     T2-weighted TSEAxial3.0 mm thickness, non-fat-suppressedSuspected area of abnormality (group of axial images through the disc level not applied)
     T1-weighted TSECoronal3.0 mm thicknessCentered onto and along the major axis of the sacrum (for suspected sacral abnormalities)
     T1-weighted FSSagittal3.0 mm thicknessConfirmation of lipoma
     T1-weighted FS C+Axial, sagittal, coronal3.0 mm thicknessSuspected infections/tumors
     DWIAxial or sagittal3.0–4.0 mm thicknessSuspected dysontogenic abnormalities, epidermoids, dermoids, abscesses
     T2-weighted GRE or EPI-GREAxial3.0 mm thicknessEvaluation of bony septum in diastematomyelia
     T1-weighted TSE C+Axial, sagittal, coronal3.0 mm thicknessSuspected mass lesions, dysontogenic abnormalities, or infections
    • Note:—DRIVE indicates driven equilibrium; C+ = postcontrast.

    • View popup
    Table 2:

    Recommended MR imaging sequences and parameters for the assessment of fetuses with suspected DMSSC

    SequencePlaneImaging ParametersNotes
    Essential sequences
     3 plane scout/localizerAxial, sagittal, coronal—For subsequent planning
     T2-weighted TSE maternal pelvisSagittal—To assess the position of the fetus; reposition the coil if the fetal ROI is not in the center of the coil
     T2-weighted SSFSE or HASTEAxial, sagittal, coronala3-4 mm thickness, no intersection gaps (TR, 2000–3000 ms, TE, 150 ms), FOV 340 mm, flip angle 160°Provides excellent anatomic detail
     T2-weighted EPI-GRE or true FISPAxial, sagittal, coronala4 mm thickness, no intersection gap (TR, 4.22 ms, TE, 1.75 ms), FOV 380 mm, flip angle 65°Evaluation of bony and vascular structures
    Optional sequences
     T1-weighted SPGRSagittal, coronal5 mm thickness, no intersection gaps (TR, 600 ms, TE, 30 ms), FOV 340 mmImproves spatial resolution with increasing gestational age
     Cine imagingVolumetric acquisition—Assesses fetal extremity mobility
    • Note:—SPGR indicates spoiled gradient recalled‐echo.

    • a Acquisition of all 3 planes in T2‐weighted SSFSE (HASTE) and T2‐weighted true FISP may not be feasible if the fetus is moving excessively; and in such a scenario, the protocol can be curtailed with T2‐weighted SSFSE in axial and coronal planes (providing anatomic detail) and T2‐weighted true FISP in sagittal plane (providing assessment of osseous structures).

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American Journal of Neuroradiology: 45 (6)
American Journal of Neuroradiology
Vol. 45, Issue 6
1 Jun 2024
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Cite this article
Ankit Balani, Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Özgür Öztekin, Valeria Capra, Martin Catala, Andrew J. Copp, Neetu Kumar, Navroop Johal, M. Zubair Tahir, Dominic Thompson, Dachling Pang, David M. Mirsky, Mai-Lan Ho, Thierry A.G.M. Huisman, Andrea Rossi, Kshitij Mankad
International Consensus Statement on the Radiologic Evaluation of Dysraphic Malformations of the Spine and Spinal Cord
American Journal of Neuroradiology Jun 2024, 45 (6) 673-680; DOI: 10.3174/ajnr.A8117

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International Consensus on Dysraphic Malformations
Ankit Balani, Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Özgür Öztekin, Valeria Capra, Martin Catala, Andrew J. Copp, Neetu Kumar, Navroop Johal, M. Zubair Tahir, Dominic Thompson, Dachling Pang, David M. Mirsky, Mai-Lan Ho, Thierry A.G.M. Huisman, Andrea Rossi, Kshitij Mankad
American Journal of Neuroradiology Jun 2024, 45 (6) 673-680; DOI: 10.3174/ajnr.A8117
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