More articles from Adult Brain
- Advanced Multicompartment Diffusion MRI Models and Their Application in Multiple Sclerosis
In this review, the authors provide an appraisal of the current literature on the physics principles, histopathologic validation, and clinical applications of advanced diffusion techniques in both brains and spinal cords of patients with MS (neurite orientation dispersion and density imaging, diffusion basis spectrum imaging, multicompartment microscopic diffusion MR imaging with the spherical mean technique, and models enabled through high-gradient diffusion MR imaging). They discuss limitations of each of the methods and directions that future research could take to provide additional validation of their roles as biomarkers of axonal and myelin injury in MS.
- The Impact of Intracortical Lesions on Volumes of Subcortical Structures in Multiple Sclerosis
The authors investigated the impact of intracortical lesions on the volumes of subcortical structures (especially the thalamus) compared with other lesions in 71 patients with MS. The volumes of intracortical lesions and white matter lesions were identified on double inversion recovery and FLAIR imaging, respectively, by using 3D Slicer. Volumes of white matter T1 hypointensities and subcortical gray matter, thalamus, caudate, putamen, and pallidum volumes were calculated using FreeSurfer. They conclude that thalamic atrophy was explained better by intracortical lesions than by white matter lesion and T1 hypointensity volumes, especially in patients with more profound disability.