More articles from Adult Brain
- Metabolic Abnormalities in the Hippocampus of Patients with Schizophrenia: A 3D Multivoxel MR Spectroscopic Imaging Study at 3T
Nineteen patients with schizophrenia and 11 matched healthy controls underwent MR imaging and multivoxel point-resolved 1H-MRS at 3T to obtain their hippocampal gray matter absolute NAA, Cr, and Cho concentrations. Patients' average hippocampal GM Cr concentrations were 19% higher than those of controls. NAA and Cho showed no differences. The authors conclude that the findings suggest the hippocampal volume deficit in schizophrenia is not due to net loss of neurons, which is in agreement with histopathology studies but not with prior 1H-MR spectroscopy reports. Elevated Cr would be consistent with hippocampal hypermetabolism.
- Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in Relapsing-Remitting Multiple Sclerosis
Both dynamic susceptibility contrast perfusion with bookend T1-calibration and pseudocontinuous arterial spin-labeling have been used recently for CBF quantification in relapsing-remitting MS. The authors compared pseudocontinuous arterial spin-labeling CBF with the bookend technique in a prospective cohort of 19 healthy controls, 19 subjects with relapsing-remitting MS without cognitive impairment, and 20 subjects with relapsing-remitting MS with cognitive impairment. Voxelwise paired t tests revealed no significant CBF differences between techniques after normalization of global meanintensities. They conclude that there is agreement between pseudocontinuous arterial spin-labeling and bookend technique CBF measurements in healthy controls and patients with relapsing-remitting MS.
- Comparison of High-Resolution MR Imaging and Digital Subtraction Angiography for the Characterization and Diagnosis of Intracranial Artery Disease
Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were evaluated. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers on both DSA and high-resolution MR imaging, and the results were compared. The 2 observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. High-resolution MR imaging showed moderate-to-excellent agreement and significant correlations with DSA on the degree of stenosis and minimal luminal diameter. The authors conclude that high-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis ofvarious intracranial artery diseases.