Article Figures & Data
Figures
- Fig 1.
Morphologic indices used in this study, in addition to maximum diameter, volume, and surface area. Formulas for their calculation, along with diagrams illustrating the relative position of various shapes on the different scales are shown. Horizontal lines indicate no aneurysm; AR, aspect ratio; SR, size ratio; max, maximum. The NSI ranges from 0 to 1 and is based on 3D geometry, while the AR and SR start at zero but have no fixed upper limit. Only SR incorporates the size of the parent artery into the calculation.
- Fig 2.
The NSI for imaging studies segregated by size (Tukey boxplots). Shaded and unshaded bars represent growing and stable groups, respectively, in each panel. Diamonds indicate the mean for each group; and the small circles, outliers.
- Fig 3.
Receiver operating characteristic curves for each of the indices included in the study, for all imaging studies, and the initial imaging study only. Area under the curve values are listed in the legends. The NSI provides the best discrimination between growing and stable aneurysms (area under the curve = 0.712 for all imaging studies, and area under the curve = 0.721 for the initial imaging study). AR indicates aspect ratio; SR, size ratio; max, maximum.
Tables
Aneurysm Growth Yes No Total Patients No. of patients 23 62 85 No. of women 20 49 69 No. of men 3 13 16 Mean age (yr) 63.6 ± 15.5 65.9 ± 11.9 65.2 ± 12.9 Atrial fibrillation 2 3 5 Cancer 3 8 11 Coronary artery disease 1 3 4 Diabetes mellitus 4 9 13 Dyslipidemia 6 32 38 Family history of intracranial aneurysm 0 3 3 History of TIA 2 2 4 History of ICH 1 1 2 History of stroke 0 3 3 Hypertension 12 32 44 Hypothyroid 4 12 16 Previous or current cigarette smoking 3 16 19 Previous SAH 2 2 4 Seizure 2 1 3 Cases Aneurysms 23 70 93 Average follow-ups 2.35 ± 1.15 2.93 ± 2.45 2.78 ± 2.21 Follow-up time (mo) 46.4 ± 29.4 51.6 ± 46.2 50.3 ± 42.6 ACA 4 16 20 ICA 8 38 46 MCA 1 8 9 PcomA 9 4 13 BA/VA 1 4 5 Sidewall aneurysm 19 58 77 Bifurcation aneurysm 4 12 16 Imaging studies All 73 275 348 <3 mm 21 74 95 3–5 mm 25 135 160 5–7 mm 15 50 65 >7 mm 12 16 28 ACA 15 59 74 ICA 25 152 177 MCA 7 29 36 PcomA 26 9 35 BA/VA 2 24 26 Index <3 mm (n = 95) 3–5 mm (n = 160) 5–7 mm (n = 65) >7 mm (n = 28) Allb (n = 348) Initialc (n = 93) Maximum diameter Growing 2.21 ± 0.66 3.93 ± 0.58 6.09 ± 0.58 8.55 ± 1.28 4.64 ± 2.33 3.98 ± 2.09 Stable 2.22 ± 0.55 3.82 ± 0.52 5.77 ± 0.58 8.78 ± 1.52 4.03 ± 1.78 4.14 ± 1.84 Volume Growing 9.41 ± 8.51 49.2 ± 49.7 151 ± 119 572 ± 287d,e 145 ± 235d,e 110 ± 197 Stable 12.5 ± 6.88 30.4 ± 20.9 108 ± 68.9 150 ± 261d 46.7 ± 81.0d 57.0 ± 106 Surface area Growing 28.1 ± 15.9 75.1 ± 49.4 144 ± 85.6 384 ± 165d,e 126 ± 146d,e 105 ± 133 Stable 30.0 ± 13.2 50.6 ± 26.4 122 ± 60.4 116 ± 140d 61.9 ± 57.4d 70.1 ± 69.5 NSI Growing 0.45 ± 0.08d,e 0.36 ± 0.10d,e 0.26 ± 0.05 0.31 ± 0.08d,f 0.36 ± 0.11d,e 0.38 ± 0.11d,f Stable 0.31 ± 0.14d 0.27 ± 0.10d 0.29 ± 0.09 0.22 ± 0.03d 0.28 ± 0.11d 0.29 ± 0.12d Aspect ratio Growing 0.89 ± 0.54 0.91 ± 0.33 1.21 ± 0.34 1.21 ± 0.27 1.03 ± 0.43 1.01 ± 0.54 Stable 0.90 ± 0.24 0.99 ± 0.29 1.09 ± 0.33 1.27 ± 0.81 1.00 ± 0.34 1.02 ± 0.40 Size ratio Growing 0.56 ± 0.25 0.94 ± 0.31 2.93 ± 1.3d,f 2.48 ± 0.71 1.49 ± 1.20 1.21 ± 0.91 Stable 0.70 ± 0.30 1.05 ± 0.34 1.63 ± 0.59d 1.96 ± 1.11 1.11 ± 0.59 1.19 ± 0.68 Index ACA ICA PcomA Maximum diameter Growing 4.66 ± 2.63 3.86 ± 1.45 5.20 ± 2.85 Stable 3.76 ± 1.77 4.36 ± 1.88 4.05 ± 1.30 Volume Growing 71.8 ± 69.6 85.5 ± 175 260 ± 324 Stable 47.2 ± 45.8 51.9 ± 99.7 82.6 ± 102 Surface area Growing 75.2 ± 60.7 87.5 ± 116 202 ± 192 Stable 57.3 ± 38.9 68.5 ± 65.4 105 ± 91.8 NSI Growing 0.31 ± 0.11b,c 0.38 ± 0.12 0.39 ± 0.08 Stable 0.22 ± 0.07b 0.31 ± 0.12 0.45 ± 0.08 Aspect ratio Growing 0.95 ± 0.25 0.90 ± 0.40 0.98 ± 0.29 Stable 1.17 ± 0.39 0.96 ± 0.33 0.73 ± 0.25 Size ratio Growing 1.53 ± 1.09 0.93 ± 0.55 1.40 ± 0.86b,c Stable 1.48 ± 0.75 1.03 ± 0.50 0.81 ± 0.33b Bifurcation (n = 16) Sidewall (n = 77) Max diameter Growing 4.19 ± 1.68 3.93 ± 2.21 Stable 3.96 ± 2.16 4.18 ± 1.79 Volume Growing 54.8 ± 52.5 122 ± 214 Stable 51.0 ± 57.1 58.2 ± 114 Surface area Growing 68.9 ± 42.9 113 ± 145 Stable 62.7 ± 51.8 71.7 ± 73.0 NSI Growing 0.31 ± 0.10 0.39 ± 0.11b,c Stable 0.22 ± 0.07 0.31 ± 0.12b Aspect ratio Growing 1.00 ± 0.33 1.01 ± 0.57 Stable 1.02 ± 0.32 1.02 ± 0.41 Size ratio Growing 1.71 ± 1.45 1.11 ± 0.77 Stable 1.37 ± 0.91 1.15 ± 0.62
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