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Research ArticlePatient Safety

Radiation Dosimetry of 3D Rotational Neuroangiography and 2D-DSA in Children

N.A. Shkumat, M.M. Shroff and P. Muthusami
American Journal of Neuroradiology March 2018, DOI: https://doi.org/10.3174/ajnr.A5568
N.A. Shkumat
aFrom the Department of Diagnostic Imaging (N.A.S., M.M.S., P.M.), The Hospital for Sick Children, Toronto, Ontario, Canada
bDepartment of Medical Imaging (N.A.S., M.M.S., P.M.), University of Toronto, Toronto, Ontario, Canada.
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M.M. Shroff
aFrom the Department of Diagnostic Imaging (N.A.S., M.M.S., P.M.), The Hospital for Sick Children, Toronto, Ontario, Canada
bDepartment of Medical Imaging (N.A.S., M.M.S., P.M.), University of Toronto, Toronto, Ontario, Canada.
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P. Muthusami
aFrom the Department of Diagnostic Imaging (N.A.S., M.M.S., P.M.), The Hospital for Sick Children, Toronto, Ontario, Canada
bDepartment of Medical Imaging (N.A.S., M.M.S., P.M.), University of Toronto, Toronto, Ontario, Canada.
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  • Fig 1.
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    Fig 1.

    Box-and-whisker plot depicting the reference point air kerma of biplane DSA and 3DRA protocols across all patients. Boxes denote median, lower, and upper quartiles, with whiskers capturing values outside the interquartile range.

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    Fig 2.

    Mean reference point air kerma as a function of projection angle for 3DRA protocols 1, 2, and 3.

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    Fig 3.

    Effective dose as a function of projection angle for 3DRA protocols 1, 2, and 3. Each line indicates the effective dose for an individual rotation.

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    Fig 4.

    Box-and-whisker plot depicting the effective dose of biplane DSA and 3DRA protocols across all patients. Boxes denote median, lower, and upper quartiles, with whiskers capturing values outside the interquartile range.

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    Fig 5.

    Box-and-whisker plot depicting the relative effective dose comparing 3DRA and biplane DSA acquisitions in the same patient. Relative comparison with the original 2D-DSA effective dose (left) and normalized DSA effective dose (right) for each 3DRA protocol. Boxes denote median, lower, and upper quartiles, with whiskers capturing values outside the interquartile range.

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    Fig 6.

    An example of the use of a 3D rotational angiographic sequence (protocol 3). A 12-year-old girl was referred from an outside institution 4 months after hemorrhage from a right frontal arteriovenous malformation. A, Postgadolinium axial 3D T1-weighted MR image shows the AVM nidus within a collapsed hemorrhagic cavity in the right superior frontal gyrus. B, Diagnostic angiography in the right internal cerebral artery in an oblique frontal projection shows the nidus fed from posterior internal frontal branches of the anterior cerebral artery, with early filling of an inferiorly draining cortical vein (arrow). The AVM was surgically resected, following which DSA (not shown) confirmed no residual nidus. C, Postgadolinium axial 3D T1-weighted MR image obtained at 6-month follow-up shows linear enhancement within the surgical cavity. Diagnostic angiography subsequently performed showed no arteriovenous shunting. D, 3D rotational angiography performed in the right internal cerebral artery using protocol 3 with 30% contrast concentration, subsequently reconstructed into CTA. E and F, 3D rotational angiography fused with the pregadolinium 3D T1-weighted MR imaging sequence, which confirmed no vascular structures within the surgical cavity in multiple planes.

Tables

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    Table 1:

    Patient demographics and indications

    ParameterValue
    Age (mean) (yr)10.4 ± 5.1
    Male/female18:6
    Procedure indication (No.)
        AVM28
        Intra-arterial chemotherapy2
        Aneurysm1
        Aberrant neurovasculature1
        Presurgical embolization1
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    Table 2:

    Technical factors for 3DRA acquisition protocols

    Projections per RotationRotationRotations Required per AcquisitionkVp TargetDetector Dose (nGy/projection)Filtration (mm Cu)Half-Value Layer (mm Al)
    Protocol 1 (subtracted)133200°2 (mask, contrast)703600.02.9
    Protocol 2 (subtracted)133200°2 (mask, contrast)902000.37.1
    Protocol 3 (unsubtracted)248200°1 (contrast)901000.68.2
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    Table 3:

    Mean, median, and range of effective dose as a function of acquisition type and protocol

    Effective Dose (mSv)
    MeanMedianRange
    2D
        Biplane DSA0.890.920.23–1.7
    3D
        Protocol 10.540.570.3–0.69
        Protocol 20.120.110.1–0.13
        Protocol 30.060.060.04–0.08
    • View popup
    Table 4:

    Relative effective dose comparison indicating mean, median, and range for direct and normalized comparisons

    Relative Effective Dose
    E3DRA/E2D-DSA (%)(E3DRA/E2D-DSA)Normalized (%)
    MeanMedianRangeMeanMedianRange
    Protocol 1686527–127616725–103
    Protocol 2151310–2414137.4–23
    Protocol 38.96.13.3–297.56.83.4–12
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N.A. Shkumat, M.M. Shroff, P. Muthusami
Radiation Dosimetry of 3D Rotational Neuroangiography and 2D-DSA in Children
American Journal of Neuroradiology Mar 2018, DOI: 10.3174/ajnr.A5568

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Radiation Dosimetry of 3D Rotational Neuroangiography and 2D-DSA in Children
N.A. Shkumat, M.M. Shroff, P. Muthusami
American Journal of Neuroradiology Mar 2018, DOI: 10.3174/ajnr.A5568
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