Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke

V. Bhatia, V. Gupta, D. Khurana, R.R. Sharma and N. Khandelwal
American Journal of Neuroradiology March 2018, DOI: https://doi.org/10.3174/ajnr.A5586
V. Bhatia
aFrom the Departments of Radiodiagnosis (V.B., V.G., N.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V. Bhatia
V. Gupta
aFrom the Departments of Radiodiagnosis (V.B., V.G., N.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for V. Gupta
D. Khurana
bNeurology (D.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Khurana
R.R. Sharma
cTransfusion Medicine (R.R.S.), Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.R. Sharma
N. Khandelwal
aFrom the Departments of Radiodiagnosis (V.B., V.G., N.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Khandelwal
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    A 70-year-old man with left hemiparesis and a baseline NIHSS score of 10 (intervention group). Axial FLAIR image (A) shows an infarct in the right periventricular and posterior limb of the internal capsule, showing diffusion restriction on diffusion-weighted image (B). MR angiogram shows no evidence of any major branch occlusion (C). Preprocedural right ICA diagnostic run (D) shows normal opacification of the MCA branches. Post–stem cell infusion right ICA run (E) shows similar findings, with normal opacification of all the branches. Axial FLAIR MR imaging at 6-month follow-up shows a reduction in infarct size. This patient had an mRS score of 1 at 6-month follow-up, and his outcome was considered good.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    A 50-year-old man with right hemiparesis and an NIHSS score of 7 (intervention group). Axial FLAIR image (A) shows an infarct in the right cortical subcortical location showing diffusion restriction on DWI (B). MR angiogram shows no evidence of any major branch occlusion. Axial FLAIR MR imaging at 6-month follow-up shows a reduction in infarct size. This patient had an mRS score of zero at 6-month follow-up, and his outcome was considered good.

Tables

  • Figures
    • View popup
    Table 1:

    Demographics and baseline clinical features of the cohort

    Control Group (No.) (%)Intervention Group (No.) (%)P Value
    Age (mean) (yr)66 ± 7.357 ± 12.2.075
    Sex ratio (M/F)6:48:2.329
    Hemiparesis (L/R)5:56:4.653
    Thrombolysis01 (10).305
    Hypertension5 (50)5 (50)1
    Diabetes mellitus6 (60)7 (70).63
    Dyslipidemia9 (90)8 (80).53
    Smoking1 (10)5 (50).051
    Atrial fibrillation02 (20).13
    Coronary artery disease1 (10)2 (20).53
    Mean baseline NIHSS score10.510.6.94
    • Note:—L indicates left; R, right.

    • View popup
    Table 2:

    Comparison of primary and secondary outcomes between the 2 groups

    ParameterControl Group (n = 10)Intervention Group (n = 10)P Value
    Mortality21.53
    Complications00
    New infarct01.305
    SICH00
    Good outcome48.068
    • Note:—SICH indicates symptomatic intracerebral hemorrhage.

Next
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
V. Bhatia, V. Gupta, D. Khurana, R.R. Sharma, N. Khandelwal
Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke
American Journal of Neuroradiology Mar 2018, DOI: 10.3174/ajnr.A5586

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke
V. Bhatia, V. Gupta, D. Khurana, R.R. Sharma, N. Khandelwal
American Journal of Neuroradiology Mar 2018, DOI: 10.3174/ajnr.A5586
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • A Retrospective Study in Tentorial DAVFs
  • Proximal Protection Devices for Carotid Stenting
  • Rescue Reentry in Carotid Near-Occlusion
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire