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Research ArticleNeurointervention

Endovascular Treatment of Dural Arteriovenous Fistulas Using Transarterial Liquid Embolization in Combination with Transvenous Balloon-Assisted Protection of the Venous Sinus

D.F. Vollherbst, C. Ulfert, U. Neuberger, C. Herweh, M. Laible, S. Nagel, M. Bendszus and M.A. Möhlenbruch
American Journal of Neuroradiology May 2018, DOI: https://doi.org/10.3174/ajnr.A5651
D.F. Vollherbst
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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  • ORCID record for D.F. Vollherbst
C. Ulfert
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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U. Neuberger
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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C. Herweh
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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M. Laible
bNeurology (M.L., S.N.), Heidelberg University Hospital, Heidelberg, Germany.
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S. Nagel
bNeurology (M.L., S.N.), Heidelberg University Hospital, Heidelberg, Germany.
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M. Bendszus
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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M.A. Möhlenbruch
aFrom the Departments of Neuroradiology (D.F.V., C.U., U.N., C.H., M.B., M.A.M.)
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    Fig 1.

    Schematic illustration of the treatment technique. A, The treatment technique is shown in the example of a Cognard I/Borden I dAVF located at the transverse and sigmoid sinuses with feeders from the occipital and middle meningeal arteries. B, After preinterventional diagnostic angiography, a balloon catheter (in black) is navigated into the affected sinus, and a microcatheter (in green) is navigated into the most promising feeder (in this example, the petrosquamosal branch of the middle meningeal artery). C, After superselective diagnostic angiographies via the microcatheter with and without balloon inflation, Onyx is injected under balloon deflation until the Onyx cast (in black) reaches the sinus. D, Subsequently, the balloon is inflated to prevent inadvertent embolization of the sinus and to enable retrograde embolization of the other arterial feeders. E, Onyx injection is continued under balloon inflation and deflation until embolization of all feeders is achieved. F, After the intervention, all feeding arteries are embolized and the sinus and the normal superficial veins (not shown) are preserved.

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    Fig 2.

    Illustration of a representative case. A, Right external carotid artery angiogram shows a Cognard IIa+b/Borden II dAVF located at the transverse and sigmoid sinuses with multiple feeding arteries out of numerous vascular territories. B, Right internal carotid artery angiogram shows dural branches of the internal carotid artery feeding the fistula (black arrow). C, Venous phase of B. Note the proximity of the fistula point (black arrow in B) to the junction of the vein of Labbé and of the inferior temporal veins into the sinus (black arrow). For successful treatment of the dAVF, the fistula point should be embolized while simultaneously preserving these veins. D, Superselective angiogram without balloon inflation via the feeder that was selected for embolization, the mastoid branch of the occipital artery (microcatheter tip marked with an open arrow). There is drainage via the sinus (white arrows) and only slight filling of the adjacent feeders (black arrow). E, Lateral x-ray shows the inflated balloon. F, Superselective angiogram after balloon inflation (microcatheter tip marked with an open arrow). Due to the temporary occlusion of the sinus, which shows only minimal enhancement at the edge of the balloon (white arrow) at the junction of the vein of Labbé and the inferior temporal veins (C), nearby feeders show marked filling of contrast agent (black arrows). The angiograms with the inflated balloon serve as a test injection to estimate the distribution of the subsequently injected liquid embolic agent. G, Onyx cast after embolization with distribution of the embolic agent in all feeding artery territories. Common carotid artery angiogram of the arterial (H) and venous (I) phases 6 months after treatment shows complete occlusion of the fistula and patency of the venous sinuses and the normal superficial veins.

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    Table 1:

    Patient demographics, clinical presentation, and angiographic features of the treated dAVFsa

    Patient demographics
        Total No. of patients22
        Patient age (yr)55 ± 15
        Male/female ratio1:1
    Clinical presentation
        Symptomatic patients22 (100%)
        Hemorrhage1 (4.6%)
        Preinterventional mRS1 ± 1
    dAVF location
        Transverse and/or sigmoid sinus19 (86.4%)
        Superior sagittal sinus2 (9.1%)
        Marginal sinus1 (4.6%)
    dAVF classification
        Cognard I7 (31.8%)
        Cognard IIa6 (27.3%)
        Cognard IIa+b9 (40.9%)
        Borden I13 (59.1%)
        Borden II9 (40.9%)
    Feeder territories
        Middle meningeal artery21 (95.5%)
        Occipital artery21 (95.5%)
        Internal carotid artery (dural branches)19 (86.4%)
        Vertebral artery (dural branches)14 (63.6%)
        Superficial temporal artery11 (50.0%)
    Other angiographic features
        Bilateral feeders13 (59.1%)
        No. of feeder territories5 ± 2
        ≥20 Feeding arteriesb19 (86.4%)
        <20 Feeding arteriesb3 (13.6%)
    • ↵a Data are presented as No. (relative frequency in %) or mean ± SD.

    • ↵b Feeding arteries with a length of ≥10 mm (measured from the dural sinus).

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    Table 2:

    Procedural parameters, treatment results, follow-up, and outcomea

    No. of treatment procedures
        Total No. of treatment procedures25
        1 treatment procedure per patient19 (86.4%)
        2 treatment procedures per patient3 (13.6%)
    Selected feeder for embolization
        Middle meningeal artery18 (80.0%)
        Occipital artery5 (24.0%)
        Others2 (8.0%)
    No. of embolization positions
        120 (80.0%)
        ≥25 (20.0%)
    Complications
        Overall complications5 (20.0%)
        Asymptomatic complications3 (12.0%)
        Transient symptomatic complications2 (8.0%)
        Symptomatic complications with permanent neurologic deficits0 (0%)
    Follow-up
        Follow-up (mo)18 ± 18
        Postinterventional angiography available17 (77.2%)
        Postinterventional MRI available22 (100%)
    Angiographic outcome
        Initial complete angiographic occlusion14 (63.6%)
        Spontaneous occlusion after subtotal endovascular occlusion5 (22.7%)
        Time from last treatment to diagnosis of spontaneous occlusion (mo)3.5 ± 6.0
        Overall complete occlusion at last examination19 (86.4%)
        Residual fistula at last examination3 (13.6%)
    Clinical outcome
        Postinterventional mRS at discharge1 ± 1
        Postinterventional mRS 6 mo after treatment1 ± 1
        Complete symptom remission after treatment15 (68.2%)
        Symptom relief after treatment6 (27.3%)
        Stable symptoms after treatment1 (4.6%)
        Worsening of symptoms after treatment0 (0%)
    • ↵a Data are presented as No. (relative frequency in %) or mean ± SD.

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D.F. Vollherbst, C. Ulfert, U. Neuberger, C. Herweh, M. Laible, S. Nagel, M. Bendszus, M.A. Möhlenbruch
Endovascular Treatment of Dural Arteriovenous Fistulas Using Transarterial Liquid Embolization in Combination with Transvenous Balloon-Assisted Protection of the Venous Sinus
American Journal of Neuroradiology May 2018, DOI: 10.3174/ajnr.A5651

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Endovascular Treatment of Dural Arteriovenous Fistulas Using Transarterial Liquid Embolization in Combination with Transvenous Balloon-Assisted Protection of the Venous Sinus
D.F. Vollherbst, C. Ulfert, U. Neuberger, C. Herweh, M. Laible, S. Nagel, M. Bendszus, M.A. Möhlenbruch
American Journal of Neuroradiology May 2018, DOI: 10.3174/ajnr.A5651
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