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Research ArticlePediatric Neuroimaging

Spinal Imaging Findings of Open Spinal Dysraphisms on Fetal and Postnatal MRI

U.D. Nagaraj, K.S. Bierbrauer, C.B. Stevenson, J.L. Peiro, F.Y. Lim, B. Zhang and B.M. Kline-Fath
American Journal of Neuroradiology September 2018, DOI: https://doi.org/10.3174/ajnr.A5760
U.D. Nagaraj
aFrom the Department of Radiology and Medical Imaging (U.D.N., B.Z., B.M.K.-F.)
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K.S. Bierbrauer
bDepartment of Pediatric Neurosurgery (K.S.B., C.B.S.)
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C.B. Stevenson
bDepartment of Pediatric Neurosurgery (K.S.B., C.B.S.)
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J.L. Peiro
cDepartment of Pediatric Surgery (J.L.P., F.Y.L.)
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F.Y. Lim
cDepartment of Pediatric Surgery (J.L.P., F.Y.L.)
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B. Zhang
aFrom the Department of Radiology and Medical Imaging (U.D.N., B.Z., B.M.K.-F.)
dDepartment of Biostatistics and Epidemiology (B.Z.),University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center; Cincinnati, Ohio.
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B.M. Kline-Fath
aFrom the Department of Radiology and Medical Imaging (U.D.N., B.Z., B.M.K.-F.)
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  • Fig 1.
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    Fig 1.

    Distribution of defect levels on fetal MR imaging.

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    Fig 2.

    Sagittal balanced fast-field echo/FIESTA image from fetal MR imaging at 24 weeks' 5 days' gestational age (A) demonstrates findings of a lumbosacral myelomeningocele with the upper level of the spinal dysraphic defect beginning at L4. Sagittal T2-FSE image from postnatal MR imaging of the spine in the same patient at 20 days of age (B) shows postoperative changes from OSD closure, with the upper level of the defect again beginning at L4 (same level), with L3 having an intact neural arch (arrow).

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    Fig 3.

    Axial T2-single-shot FSE image through a 23 weeks' 3 days' gestational age fetus (A) with a myelocele demonstrates splitting of the neural placode (arrow), consistent with a type II split cord malformation. Axial balanced fast-field echo/FIESTA image from postnatal spine MR imaging of the same patient at 4 weeks of age confirms the prenatal findings of split cord malformation status post repair (arrow).

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    Fig 4.

    Sagittal balanced fast-field echo/FIESTA image from fetal MR imaging at 32 weeks' gestational age (A) shows a spinal cord syrinx in the cervicothoracic spine (arrow). Sagittal balanced fast-field echo/FIESTA image from postnatal spine MR imaging in the same patient at 1 month of age (B) shows persistence of the syrinx (arrow).

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    Table 1:

    Summary of cohort

    CharacteristicsData (N = 119)
    Sex
        Male43.7% (52/119)
        Female56.3% (67/119)
    Average GA at fetal MRI (wk)23.9 ± 3.6
    Fetal Chiari grade
        III81.5% (97/119)
        II11.8% (14/119)
        I6.7% (8/119)
    Clubfoot
        None76.5% (91/119)
        Unilateral5.9% (7/119)
        Bilateral17.6% (21/119)
    In utero vs postnatal repair
        Open in utero repair31.9% (38/119)
        Postnatal repair68.1% (81/119)
    Average age at postnatal spine MRI (days)19.9 ± 20.2
    • Note:—GA indicates gestational age.

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    Table 2:

    Significance of defect level on fetal MRI

    Chiari Grade (I–III)Lateral Ventricular Size (mm)Third Ventricular Size (mm)Clubfoot (Absent, Unilateral, Bilateral)
    Level of spinal dysraphic defectP = .07P = .001P = .86P = .3
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    Table 3:

    Postnatal spine MRI findings

    Percentage of Total (N = 119)Percentage of Prenatal Repair Group (n = 38)Percentage of Postnatal Repair Group (n = 78)P Value
    Extraspinal postoperative fluid collection32.8% (38/116)5.3% (2/38)46.2% (36/78)P < .001
    Arachnoid cyst3.4% (4/119)5.3% (2/38)2.6% (2/78)P = .46
    Syrinx39.5% (47/119)36.8% (14/38)41% (32/78)P = .67
    No syrinx, no fluid collection, and no arachnoid cyst36.2% (42/116)55.3% (21/38)26.9% (21/78)P = .003
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U.D. Nagaraj, K.S. Bierbrauer, C.B. Stevenson, J.L. Peiro, F.Y. Lim, B. Zhang, B.M. Kline-Fath
Spinal Imaging Findings of Open Spinal Dysraphisms on Fetal and Postnatal MRI
American Journal of Neuroradiology Sep 2018, DOI: 10.3174/ajnr.A5760

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Spinal Imaging Findings of Open Spinal Dysraphisms on Fetal and Postnatal MRI
U.D. Nagaraj, K.S. Bierbrauer, C.B. Stevenson, J.L. Peiro, F.Y. Lim, B. Zhang, B.M. Kline-Fath
American Journal of Neuroradiology Sep 2018, DOI: 10.3174/ajnr.A5760
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