Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration

S. Gaudino; M. Martucci; A. Botto; E. Ruberto; E. Leone; A. Infante; A. Ramaglia; M. Caldarelli; P. Frassanito; F.M. Triulzi; C. Colosimo

doi:10.3174/ajnr.A5954

Research ArticlePediatric Neuroimaging

Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration

S. Gaudino, M. Martucci, A. Botto, E. Ruberto, E. Leone, A. Infante, A. Ramaglia, M. Caldarelli, P. Frassanito, F.M. Triulzi and C. Colosimo

American Journal of Neuroradiology January 2019, DOI: https://doi.org/10.3174/ajnr.A5954

S. Gaudino

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

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M. Martucci

cOperative Unit di Neuroradiologia (M.M.), Azienda Ospedaliera, Università di Padova, Padova, Italy

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A. Botto

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

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E. Ruberto

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

bIstituto di Radiologia (E.R., E.L., A.R., C.C), Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

gUniversità Cattolica del Sacro Cuore (E.R., E.L., A.R., C.C), Milan, Italy.

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E. Leone

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

bIstituto di Radiologia (E.R., E.L., A.R., C.C), Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

gUniversità Cattolica del Sacro Cuore (E.R., E.L., A.R., C.C), Milan, Italy.

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A. Infante

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

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A. Ramaglia

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

bIstituto di Radiologia (E.R., E.L., A.R., C.C), Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

gUniversità Cattolica del Sacro Cuore (E.R., E.L., A.R., C.C), Milan, Italy.

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M. Caldarelli

dNeurochirurgia infantile (M.C., P.F.), Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere, Rome, Italy

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P. Frassanito

dNeurochirurgia infantile (M.C., P.F.), Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere, Rome, Italy

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F.M. Triulzi

eNeuroradiology Unit (F.M.T.), Foundation Istituto di Ricovero e Cura a Carattere Scientifico, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy

fDepartment of Pathophysiology and Transplantation (F.M.T.), University of Milan, Milan, Italy

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C. Colosimo

aFrom the Operative Unit Radiodiagnostica e Neuroradiologia (S.G.,A.B., E.R., E.L., A.I., A.R., C.C.), Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica e Ematologia

bIstituto di Radiologia (E.R., E.L., A.R., C.C), Fondazione Policlinico Universitario A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy

gUniversità Cattolica del Sacro Cuore (E.R., E.L., A.R., C.C), Milan, Italy.

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Fig 1.
Scatterplot of the PSD and FWHM distribution in the study population. Dotted lines indicate the threshold values of 30% for PSD (A) and 7 seconds for FWHM (B).
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Fig 2.
Boxplot of lenticular FWHM (A) shows no significant correlation with flow rate. Boxplot of lenticular PSD (B) shows a significant difference between the 1- and 3-mL/s groups.
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Fig 3.
Boxplot of lenticular FWHM shows a significant correlation with sex the 0- to 6-year-old (A) and 13- to 16-year-old (B) groups.

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Cite this article

S. Gaudino, M. Martucci, A. Botto, E. Ruberto, E. Leone, A. Infante, A. Ramaglia, M. Caldarelli, P. Frassanito, F.M. Triulzi, C. Colosimo

Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration

American Journal of Neuroradiology Jan 2019, DOI: 10.3174/ajnr.A5954

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Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration

S. Gaudino, M. Martucci, A. Botto, E. Ruberto, E. Leone, A. Infante, A. Ramaglia, M. Caldarelli, P. Frassanito, F.M. Triulzi, C. Colosimo

American Journal of Neuroradiology Jan 2019, DOI: 10.3174/ajnr.A5954

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