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Research ArticlePediatric Neuroimaging

Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes

R.A. Didier, J.S. Martin-Saavedra, E.R. Oliver, S.E. DeBari, L.T. Bilaniuk, L.J. Howell, J.S. Moldenhauer, N.S. Adzick, G.G. Heuer and B.G. Coleman
American Journal of Neuroradiology September 2020, DOI: https://doi.org/10.3174/ajnr.A6745
R.A. Didier
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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J.S. Martin-Saavedra
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
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E.R. Oliver
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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S.E. DeBari
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
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  • ORCID record for S.E. DeBari
L.T. Bilaniuk
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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L.J. Howell
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
dPerelman School of Medicine (R.A.D., E.R.O., L.T.B., J.S.M., N.S.A., G.G.H., B.G.C.), University of Pennsylvania, Philadelphia, Pennsylvania
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J.S. Moldenhauer
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
dPerelman School of Medicine (R.A.D., E.R.O., L.T.B., J.S.M., N.S.A., G.G.H., B.G.C.), University of Pennsylvania, Philadelphia, Pennsylvania
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N.S. Adzick
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
dPerelman School of Medicine (R.A.D., E.R.O., L.T.B., J.S.M., N.S.A., G.G.H., B.G.C.), University of Pennsylvania, Philadelphia, Pennsylvania
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G.G. Heuer
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
dPerelman School of Medicine (R.A.D., E.R.O., L.T.B., J.S.M., N.S.A., G.G.H., B.G.C.), University of Pennsylvania, Philadelphia, Pennsylvania
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B.G. Coleman
aDepartments of Radiology (R.A.D., J.S.M-S., E.R.O., S.E.D., L.T.B., B.G.C.)
bCenter for Fetal Diagnosis and Treatment (R.A.D., E.R.O., S.E.D., L.T.B., L.J.H., J.S.M., N.S.A., G.G.H., B.G.C.)
cSurgery (L.J.H., J.S.M., N.S.A., G.G.H.), The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
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References

  1. 1.↵
    1. Coleman BG,
    2. Langer JE,
    3. Horii SC
    . The diagnostic features of spina bifida: the role of ultrasound. Fetal Diagn Ther 2015;37:179–96 doi:10.1159/000364806 pmid:25341807
    CrossRefPubMed
  2. 2.↵
    1. Goldstein RB,
    2. Podrasky AE,
    3. Filly RA, et al
    . Effacement of the fetal cisterna magna in association with myelomeningocele. Radiology 1989;172:409–13 doi:10.1148/radiology.172.2.2664865 pmid:2664865
    CrossRefPubMed
  3. 3.↵
    1. D’Addario V,
    2. Rossi AC,
    3. Pinto V, et al
    . Comparison of six sonographic signs in the prenatal diagnosis of spina bifida. J Perinat Med 2008;36:330–34 doi:10.1515/JPM.2008.052 pmid:18598123
    CrossRefPubMed
  4. 4.↵
    1. Pretorius DH,
    2. Russ PD,
    3. Rumack CM, et al
    . Diagnosis of brain neuropathology in utero. Neuroradiology 1986;28:386–97 doi:10.1007/BF00344094 pmid:3540704
    CrossRefPubMed
  5. 5.↵
    1. Araujo Júnior E,
    2. Nakano ML,
    3. Nardozza LMM, et al
    . Comparison between 2D ultrasonography and magnetic resonance imaging for assessing brain and spine parameters in fetuses with spina bifida. Arch Gynecol Obstet 2013;287:845–49 doi:10.1007/s00404-012-2656-0 pmid:23208462
    CrossRefPubMed
  6. 6.↵
    1. Aertsen M,
    2. Verduyckt J,
    3. De Keyzer F, et al
    . Reliability of MR imaging-based posterior fossa and brain stem measurements in open spinal dysraphism in the era of fetal surgery. AJNR Am J Neuroradiol 2019;40:191–98 doi:10.3174/ajnr.A5930 pmid:30591508
    Abstract/FREE Full Text
  7. 7.↵
    1. Aaronson OS,
    2. Hernanz-Schulman M,
    3. Bruner JP, et al
    . Myelomeningocele: prenatal evaluation–comparison between transabdominal US and MR imaging. Radiology 2003;227:839–43 doi:10.1148/radiol.2273020535 pmid:12714679
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Variend S,
    2. Emery JL
    . Cervical dislocation of the cerebellum in children with meningomyelocele. Teratology 1976;13:281–89 doi:10.1002/tera.1420130307
    CrossRef
  9. 9.↵
    1. Bouchard S,
    2. Davey MG,
    3. Rintoul NE, et al
    . Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. J Pediatr Surg 2003;38:451–58 doi:10.1053/jpsu.2003.50078 pmid:12632366
    CrossRefPubMed
  10. 10.↵
    1. Paek BW,
    2. Farmer DL,
    3. Wilkinson CC, et al
    . Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs. Am J Obstet Gynecol 2000;183:1119–23 doi:10.1067/mob.2000.108867 pmid:11084552
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Adzick NS,
    2. Thom EA,
    3. Spong CY, et al
    . A randomized trial of prenatal versus postnatal repair of myelomeningocele. N Engl J Med 2011;364:993-1004 doi:10.1056/NEJMoa1014379 pmid:21306277
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Moldenhauer JS,
    2. Soni S,
    3. Rintoul NE, et al
    . Fetal myelomeningocele repair: the post-MOMS experience at the Children’s Hospital of Philadelphia. Fetal Diagn Ther 2015;37:235–40 doi:10.1159/000365353 pmid:25138132
    CrossRefPubMed
  13. 13.↵
    1. Moldenhauer JS,
    2. Adzick NS
    . Fetal surgery for myelomeningocele: after the Management of Myelomeningocele Study (MOMS). Semin Fetal Neonatal Med 2017;22:360–66 doi:10.1016/j.siny.2017.08.004 pmid:29031539
    CrossRefPubMed
  14. 14.↵
    1. Heuer GG,
    2. Moldenhauer JS,
    3. Adzick NS
    . Prenatal surgery for myelomeningocele: review of the literature and future directions. Childs Nerv Syst 2017;33:1149–55 doi:10.1007/s00381-017-3440-z pmid:28516217
    CrossRefPubMed
  15. 15.↵
    1. Kabagambe SK,
    2. Jensen GW,
    3. Chen YJ, et al
    . Fetal surgery for myelomeningocele: a systematic review and meta-analysis of outcomes in fetoscopic versus open repair. Fetal Diagn Ther 2018;43:161–74 doi:10.1159/000479505 pmid:28910784
    CrossRefPubMed
  16. 16.↵
    1. Nagaraj UD,
    2. Bierbrauer KS,
    3. Zhang B, et al
    . Hindbrain herniation in Chiari II malformation on fetal and postnatal MRI. AJNR Am J Neuroradiol 2017;38:1031–36 doi:10.3174/ajnr.A5116 pmid:28279990
    Abstract/FREE Full Text
  17. 17.↵
    1. Bennett KA,
    2. Carroll MA,
    3. Shannon CN, et al
    . Reducing perinatal complications and preterm delivery for patients undergoing in utero closure of fetal myelomeningocele: further modifications to the multidisciplinary surgical technique. PED 2014;14:108–14 doi:10.3171/2014.3.PEDS13266 pmid:24784979
    CrossRefPubMed
  18. 18.↵
    1. Moron AF,
    2. Athanasiou A,
    3. Barbosa M, et al
    . Amniotic fluid lactic acid and matrix metalloproteinase-8 levels at the time of fetal surgery for a spine defect: association with subsequent preterm prelabour rupture of membranes. BJOG 2018;125:1288–92 doi:10.1111/1471-0528.15298 pmid:29786973
    CrossRefPubMed
  19. 19.↵
    1. Zaretsky MV,
    2. Liechty KW,
    3. Galan HL, et al
    . Modified hysterotomy closure technique for open fetal surgery. Fetal Diagn Ther 2018;44:105–11 doi:10.1159/000479683 pmid:28873371
    CrossRefPubMed
  20. 20.↵
    1. Elbabaa SK,
    2. Gildehaus AM,
    3. Pierson MJ, et al
    . First 60 fetal in-utero myelomeningocele repairs at Saint Louis Fetal Care Institute in the post-MOMS trial era: hydrocephalus treatment outcomes (endoscopic third ventriculostomy versus ventriculo-peritoneal shunt). Childs Nerv Syst 2017;33:1157–68 doi:10.1007/s00381-017-3428-8 pmid:28470384
    CrossRefPubMed
  21. 21.↵
    1. Zamłyński J,
    2. Olejek A,
    3. Koszutski T, et al
    . Comparison of prenatal and postnatal treatments of spina bifida in Poland–a non-randomized, single-center study. J Matern Neonatal Med 2014;27:1409–17 doi:10.3109/14767058.2013.858689 pmid:24156622
    CrossRefPubMed
  22. 22.↵
    1. Pedreira DAL,
    2. Zanon N,
    3. Nishikuni K, et al
    . Endoscopic surgery for the antenatal treatment of myelomeningocele: the CECAM trial. Am J Obstet Gynecol 2016;214:111.E1–111.E11 doi:10.1016/j.ajog.2015.09.065 pmid:26386383
    CrossRefPubMed
  23. 23.↵
    1. Cohen J
    . A coefficient of agreement for nominal scales. Educ Psychol Meas 1960;20:37–46 doi:10.1177/001316446002000104
    CrossRefWeb of Science
  24. 24.↵
    1. Adzick NS
    . Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention. Semin Fetal Neonatal Med 2010;15:9–14 doi:10.1016/j.siny.2009.05.002 pmid:19540177
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Danzer E,
    2. Johnson MP,
    3. Adzick NS
    . Fetal surgery for myelomeningocele: progress and perspectives. Dev Med Child Neurol 2012;54:8–14 doi:10.1111/j.1469-8749.2011.04049.x pmid:21745203
    CrossRefPubMed
  26. 26.↵
    1. Partridge EA,
    2. Flake AW
    . Maternal-fetal surgery for structural malformations. Best Pract Res Clin Obstet Gynaecol 2012;26:669–82 doi:10.1016/j.bpobgyn.2012.03.003 pmid:22542765
    CrossRefPubMed
  27. 27.↵
    1. Sari A,
    2. Ahmetoglu A,
    3. Dinc H, et al
    . Fetal biometry: size and configuration of the third ventricle. Acta Radiol 2005;46:631–35 doi:10.1080/02841850510021715 pmid:16334847
    CrossRefPubMed
  28. 28.↵
    1. Nagaraj UD,
    2. Peiro JL,
    3. Bierbrauer KS, et al
    . Evaluation of subependymal gray matter heterotopias on fetal MRI. AJNR Am J Neuroradiol 2016;37:720–25 doi:10.3174/ajnr.A4585 pmid:26585262
    Abstract/FREE Full Text
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R.A. Didier, J.S. Martin-Saavedra, E.R. Oliver, S.E. DeBari, L.T. Bilaniuk, L.J. Howell, J.S. Moldenhauer, N.S. Adzick, G.G. Heuer, B.G. Coleman
Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6745

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Fetal Intraventricular Hemorrhage in Open Neural Tube Defects: Prenatal Imaging Evaluation and Perinatal Outcomes
R.A. Didier, J.S. Martin-Saavedra, E.R. Oliver, S.E. DeBari, L.T. Bilaniuk, L.J. Howell, J.S. Moldenhauer, N.S. Adzick, G.G. Heuer, B.G. Coleman
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6745
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