Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging

Prediction of Human Papillomavirus Status and Overall Survival in Patients with Untreated Oropharyngeal Squamous Cell Carcinoma: Development and Validation of CT-Based Radiomics

Y. Choi, Y. Nam, J. Jang, N.-Y. Shin, K.-J. Ahn, B.-S. Kim, Y.-S. Lee and M.-S. Kim
American Journal of Neuroradiology September 2020, DOI: https://doi.org/10.3174/ajnr.A6756
Y. Choi
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Choi
Y. Nam
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
dDivision of Biomedical Engineering (Y.N.), Hankuk University of Foreign Studies, Yongin-Si, Gyeonggi‐do, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Nam
J. Jang
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Jang
N.-Y. Shin
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N.-Y. Shin
K.-J. Ahn
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.-J. Ahn
B.-S. Kim
aDepartments of Radiology (Y.C., Y.N., J.J., N.-Y.S, K.-J.A., B.-S.K.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B.-S. Kim
Y.-S. Lee
bHospital Pathology (Y.-S.L.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y.-S. Lee
M.-S. Kim
cOtolaryngology-Head and Neck Surgery (M.-S.K.), Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.-S. Kim
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Pytynia KB,
    2. Dahlstrom KR,
    3. Sturgis EM
    . Epidemiology of HPV-associated oropharyngeal cancer. Oral Oncol 2014;50:380–86 doi:10.1016/j.oraloncology.2013.12.019 pmid:24461628
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Ang KK,
    2. Harris J,
    3. Wheeler R, et al
    . Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24–35 doi:10.1056/NEJMoa0912217 pmid:20530316
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Chaturvedi AK,
    2. Engels EA,
    3. Pfeiffer RM, et al
    . Human papillomavirus and rising oropharyngeal cancer incidence in the United States. JCO 2011;29:4294–4301 doi:10.1200/JCO.2011.36.4596 pmid:21969503
    Abstract/FREE Full Text
  4. 4.↵
    1. Ragin CC,
    2. Taioli E
    . Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis. Int J Cancer 2007;121:1813–20 doi:10.1002/ijc.22851 pmid:17546592
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. O'Sullivan B,
    2. Huang SH,
    3. Siu LL, et al
    . Deintensification candidate subgroups in human papillomavirus–related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol 2013;31:543–50 doi:10.1200/JCO.2012.44.0164 pmid:23295795
    Abstract/FREE Full Text
  6. 6.↵
    1. Huang SH,
    2. Xu W,
    3. Waldron J, et al
    . Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas. J Clin Oncol 2015;33:836–45 doi:10.1200/JCO.2014.58.6412 pmid:25667292
    Abstract/FREE Full Text
  7. 7.↵
    1. O'Sullivan B,
    2. Huang SH,
    3. Su J, et al
    . Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal Cancer Network for Staging (ICON-S): a multicentre cohort study. Lancet Oncol 2016;17:440–51 doi:10.1016/S1470-2045(15)00560-4 pmid:26936027
    CrossRefPubMed
  8. 8.↵
    1. Gillies RJ,
    2. Kinahan PE,
    3. Hricak H
    . Radiomics: images are more than pictures: they are data. Radiology 2016;278:563–77 doi:10.1148/radiol.2015151169 pmid:26579733
    CrossRefPubMed
  9. 9.↵
    1. Ravanelli M,
    2. Grammatica A,
    3. Tononcelli E, et al
    . Correlation between human papillomavirus status and quantitative MR imaging parameters including diffusion-weighted imaging and texture features in oropharyngeal carcinoma. AJNR Am J Neuroradiol 2018;39:1878–83 doi:10.3174/ajnr.A5792 pmid:30213805
    Abstract/FREE Full Text
  10. 10.↵
    1. Driessen JP,
    2. Caldas-Magalhaes J,
    3. Janssen LM, et al
    . Diffusion-weighted MR imaging in laryngeal and hypopharyngeal carcinoma: association between apparent diffusion coefficient and histologic findings. Radiology 2014;272:456–63 doi:10.1148/radiol.14131173 pmid:24749712
    CrossRefPubMed
  11. 11.↵
    1. Westra WH
    . The morphologic profile of HPV-related head and neck squamous carcinoma: implications for diagnosis, prognosis, and clinical management. Head Neck Pathol 2012;6(Supple 1):48–54 doi:10.1007/s12105-012-0371-6 pmid:22782223
    CrossRefPubMed
  12. 12.↵
    1. Leijenaar RT,
    2. Carvalho S,
    3. Hoebers FJ, et al
    . External validation of a prognostic CT-based radiomic signature in oropharyngeal squamous cell carcinoma. Acta Oncol 2015;54:1423–29 doi:10.3109/0284186X.2015.1061214 pmid:26264429
    CrossRefPubMed
  13. 13.↵
    1. Ou D,
    2. Blanchard P,
    3. Rosellini S, et al
    . Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to human papillomavirus status. Oral Oncol 2017;71:150–55 doi:10.1016/j.oraloncology.2017.06.015 pmid:28688683
    CrossRefPubMed
  14. 14.↵
    1. Bogowicz M,
    2. Riesterer O,
    3. Ikenberg K, et al
    . Computed tomography radiomics predicts HPV status and local tumor control after definitive radiochemotherapy in head and neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2017;99:921–98 doi:10.1016/j.ijrobp.2017.06.002 pmid:28807534
    CrossRefPubMed
  15. 15.↵
    1. Ren J,
    2. Tian J,
    3. Yuan Y, et al
    . Magnetic resonance imaging based radiomics signature for the preoperative discrimination of stage I-II and III-IV head and neck squamous cell carcinoma. Eur J Radiol 2018;106:1–6 doi:10.1016/j.ejrad.2018.07.002 pmid:30150029
    CrossRefPubMed
  16. 16.↵
    1. Aerts HJ,
    2. Velazquez ER,
    3. Leijenaar RT, et al
    . Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun 2014;5:4006 doi:10.1038/ncomms5006 pmid:24892406
    CrossRefPubMed
  17. 17.↵
    1. Moltz JH,
    2. Bornemann L,
    3. Kuhnigk J-M, et al
    . Advanced segmentation techniques for lung nodules, liver metastases, and enlarged lymph nodes in CT scans. IEEE J Sel Top Signal Process 2009;3:122–34 doi:10.1109/JSTSP.2008.2011107
    CrossRef
  18. 18.↵
    1. van Griethuysen JJ,
    2. Fedorov A,
    3. Parmar C, et al
    . Computational radiomics system to decode the radiographic phenotype. Cancer Res 2017;77:e104–07 doi:10.1158/0008-5472.CAN-17-0339 pmid:29092951
    Abstract/FREE Full Text
  19. 19.↵
    1. Kursa MB,
    2. Rudnicki WR
    . Feature selection with the Boruta package. J Stat Softw 2010;36:1–13 doi:10.18637/jss.v036.i11
    CrossRefPubMed
  20. 20.↵
    1. Sauerbrei W,
    2. Royston P,
    3. Binder H
    . Selection of important variables and determination of functional form for continuous predictors in multivariable model building. Statist Med 2007;26:5512–28 doi:10.1002/sim.3148 pmid:18058845
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Huang C,
    2. Cintra M,
    3. Brennan K, et al
    . Development and validation of radiomic signatures of head and neck squamous cell carcinoma molecular features and subtypes. EBioMedicine 2019;45:70–80 doi:10.1016/j.ebiom.2019.06.034 pmid:31255659
    CrossRefPubMed
  22. 22.↵
    1. Apostolova I,
    2. Steffen IG,
    3. Wedel F, et al
    . Asphericity of pretherapeutic tumour FDG uptake provides independent prognostic value in head-and-neck cancer. Eur Radiol 2014;24:2077–87 doi:10.1007/s00330-014-3269-8 pmid:24965509
    CrossRefPubMed
  23. 23.↵
    1. Buch K,
    2. Fujita A,
    3. Li B, et al
    . Using texture analysis to determine human papillomavirus status of oropharyngeal squamous cell carcinomas on CT. AJNR Am J Neuroradiol 2015;36:1343–48 doi:10.3174/ajnr.A4285 pmid:25836725
    Abstract/FREE Full Text
  24. 24.↵
    1. Fujita A,
    2. Buch K,
    3. Li B, et al
    . Difference between HPV-positive and HPV-negative non-oropharyngeal head and neck cancer: texture analysis features on CT. J Compu Assist Tomogr 2016;40:43–47 doi:10.1097/RCT.0000000000000320 pmid:26466116
    CrossRefPubMed
  25. 25.↵
    1. Traverso A,
    2. Wee L,
    3. Dekker A, et al
    . Repeatability and reproducibility of radiomic features: a systematic review. Int J Radiat Oncol Biol Phys 2018;102:1143–58 doi:10.1016/j.ijrobp.2018.05.053 pmid:30170872
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Prediction of Human Papillomavirus Status and Overall Survival in Patients with Untreated Oropharyngeal Squamous Cell Carcinoma: Development and Validation of CT-Based Radiomics
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Y. Choi, Y. Nam, J. Jang, N.-Y. Shin, K.-J. Ahn, B.-S. Kim, Y.-S. Lee, M.-S. Kim
Prediction of Human Papillomavirus Status and Overall Survival in Patients with Untreated Oropharyngeal Squamous Cell Carcinoma: Development and Validation of CT-Based Radiomics
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6756

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Prediction of Human Papillomavirus Status and Overall Survival in Patients with Untreated Oropharyngeal Squamous Cell Carcinoma: Development and Validation of CT-Based Radiomics
Y. Choi, Y. Nam, J. Jang, N.-Y. Shin, K.-J. Ahn, B.-S. Kim, Y.-S. Lee, M.-S. Kim
American Journal of Neuroradiology Sep 2020, DOI: 10.3174/ajnr.A6756
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgment
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Systematic review of prognostic models for predicting recurrence and survival in patients with treated oropharyngeal cancer
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

Head and Neck Imaging

  • Hydrops Herniation into the Semicircular Canals
  • ASL Sensitivity for Head and Neck Paraganglioma
  • Post SRS Peritumoral Hyperintense Signal of VSs
Show more Head and Neck Imaging

Functional

  • Kurtosis and Epileptogenic Tubers: A Pilot Study
  • Glutaric Aciduria Type 1: DK vs. Conventional MRI
  • Multiparametric MRI in PEDS Pontine Glioma
Show more Functional

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire