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Research ArticleNeurointervention

Intentional Stent Stenosis to Prevent Hyperperfusion Syndrome after Carotid Artery Stenting for Extremely High-Grade Stenosis

T. Mori, K. Yoshioka, Y. Tanno and S. Kasakura
American Journal of Neuroradiology November 2020, DOI: https://doi.org/10.3174/ajnr.A6853
T. Mori
aFrom the Department of Stroke Treatment, Shonan Kamakura General Hospital, Kamakura, Japan.
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K. Yoshioka
aFrom the Department of Stroke Treatment, Shonan Kamakura General Hospital, Kamakura, Japan.
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Y. Tanno
aFrom the Department of Stroke Treatment, Shonan Kamakura General Hospital, Kamakura, Japan.
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S. Kasakura
aFrom the Department of Stroke Treatment, Shonan Kamakura General Hospital, Kamakura, Japan.
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  • FIG 1.
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    FIG 1.

    Angiograms before and during gentle CAS and at 4 months. A, Angiograms before CAS reveal extremely high-grade stenosis (arrow) and a “reduced MCA perfusion territory” in the middle cerebral artery (arrowhead). B, An inflated balloon with a 3.0-mm diameter. C, Angiography after CAS shows a residual stent stenosis. D, Angiography at 4 months shows self-expansion of the stent.

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    FIG 2.

    MRA and SPECT in the same case as in Fig 1. A, MRA before CAS reveals an MCA rSI value of 0.44: [(x: 784) divided by (y: 1775)]. B, SPECT before CAS demonstrates a CBF decrease in the right MCA territory (arrows). AI was 80.3%% [(a: 31.94) divided by (b: 39.78)], and rCBF% was 83.9% [(a: 31.94) divided by (c: 38.07)]. C, MRA after CAS reveals an MCA rSI of 1.16: [(x: 2967) divided by (y: 2667)]. D, SPECT after CAS demonstrates a CBF increase in the right MCA territory (arrows). AI% was 92.7% [(a: 37.95) divided by (b: 40.93)] and rCBF% was 99.9% [(a: 37.95) divided by (c: 37.99)]. rSI indicates relative signal intensity.

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  • Changes in luminal diameters and hemodynamic factors before and after CAS

    CAS Procedure Strategy (n = 28)Gentle CAS: Intentional Residual Stent Stenosis
    BeforeAfter
    NASCET (%) (median) (IQR)81.8 (77.9–89.1)39.5 (29.6–51.1)a
    MLD before and MSD after CAS (median) (IQR) (mm)0.63 (0.4–0.94)2.9 (2.6–3.7)a
    MCA relative SI (median) (IQR)0.73 (0.57–0.85)1.01 (0.9–1.06)a
    PSV (median) (IQR) (cm/s)316 (198.8–389.9)91.9 (70.7–144)a
    AI% (median) (IQR)96.9 (92.3–100.0)100.8 (93.6–103.9)b
    rCBF% (median) (IQR)88.9 (83.7–94.8)94.6 (91.4–100.6)b
    AVDO2 (median) (IQR) (O2 mL/mL)6.9 (6.0–7.8)6.3 (5.1–6.8)c
    OEF (median) (IQR)0.41 (0.37–0.46)0.41 (0.35–0.43)
    SBP (median) (IQR) (mm Hg)153.5 (142.5–167.5)132.5 (115.8–140.8a
    DBP (median) (IQR) (mm Hg)77.5 (70–87.8)67 (62–71.8)a
    Average BP (median) (IQR) (mm Hg)104.9 (94.7–110.9)88.7 (82.8–90.8)a
    • Note:—IQR indicates interquartile range; DBP, diastolic blood pressure; MSD, minimal stent diameter; SBP, systolic blood pressure.

    • ↵a P < .0001 between paired groups.

    • ↵b P < .01.

    • ↵c P < .05.

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T. Mori, K. Yoshioka, Y. Tanno, S. Kasakura
Intentional Stent Stenosis to Prevent Hyperperfusion Syndrome after Carotid Artery Stenting for Extremely High-Grade Stenosis
American Journal of Neuroradiology Nov 2020, DOI: 10.3174/ajnr.A6853

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Intentional Stent Stenosis to Prevent Hyperperfusion Syndrome after Carotid Artery Stenting for Extremely High-Grade Stenosis
T. Mori, K. Yoshioka, Y. Tanno, S. Kasakura
American Journal of Neuroradiology Nov 2020, DOI: 10.3174/ajnr.A6853
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