Article Figures & Data
Figures
- FIG 1.
Violin plots stratified by scan category. Boxplots within each plot have medians and interquartile ranges. The median age and interquartile range of volunteers with normal examination findings were 28 and 42 years, respectively. The median age and interquartile range of volunteers with abnormal examination findings for which follow-up was not recommended were 61 and 27 years, respectively. The median age and interquartile range of volunteers with abnormal examinations for which follow-up was recommended were 58 and 37 years, respectively.
- FIG 2.
Illustrative cases of incidental findings for which clinical follow-up was recommended. Case examples of the 3 most frequently encountered abnormality categories, lesions marked by arrows, all reportedly asymptomatic at the time of scan. A, Vascular: a 38-year-old participant with trisomy 21 and normal scan findings 2 years earlier and found to have bihemispheric ischemic lesions, suspected to be cardioembolic versus Moyamoya vasculopathy (axial T2-FLAIR). B, Neoplastic: a 68-year-old participant with normal research scan findings 3 years earlier now has an infiltrative left parietal mass, later proven to be a glioblastoma (axial T2-FLAIR). C, Congenital: a 29-year-old participant with extensive left posterior Sylvian polymicrogyria (sagittal T1).
Tables
Male Female P Value Sample size 7782 8618 <.001 Age (mean) (yr) 39 (SD, 24) 41 (SD, 23) <.001 No history of brain lesion (ie, typical control) 6155 6995 <.001 Recruited due to known condition 1627 1623 <.001 - Table 2:
Comparison between concerns of nonradiologists about initial imaging versus impressions of neuroradiologistsa
Incidental Finding Present Incidental Finding Absent Nonradiologist concern present 52 (TP) 81 (FP) PPV = 0.39 Nonradiologist concern absent 2807 (FN) 13,593 (TN) NPV = 0.83 Sensitivity = 0.02 Specificity = 0.99 Note:—TP indicates true-positive; FP, false-positive; TN, true-negative; FN, false-negative.
↵a PPV = TP/(TP + FP). NPV = TN/(FN + TN). Sensitivity = TP/(TP + FN). Specificity = TN/(TN + FP).
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