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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain

Long-Term Follow-up of Multinodular and Vacuolating Neuronal Tumors and Implications for Surveillance Imaging

S. Dogra, D. Zagzag, M. Young, J. Golfinos, D. Orringer and R. Jain
American Journal of Neuroradiology July 2023, DOI: https://doi.org/10.3174/ajnr.A7946
S. Dogra
aFrom the Departments of Radiology (S.D., M.Y., R.J.)
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D. Zagzag
bPathology (D.Z.)
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M. Young
aFrom the Departments of Radiology (S.D., M.Y., R.J.)
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J. Golfinos
cNeurosurgery (J.G., D.O., R.J.), New York University Grossman School of Medicine, New York, New York
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D. Orringer
cNeurosurgery (J.G., D.O., R.J.), New York University Grossman School of Medicine, New York, New York
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R. Jain
aFrom the Departments of Radiology (S.D., M.Y., R.J.)
cNeurosurgery (J.G., D.O., R.J.), New York University Grossman School of Medicine, New York, New York
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Figures

  • FIG 1.
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    FIG 1.

    A, Low-power view shows multiple discrete nodules and the typical multinodular and vacuolating features of the tumor. The Luxol fast blue stain helps delineate the nodules of various sizes, and the pale staining indicates the variable loss of myelin in tumor nodules present in the white matter. Mitotic figures, necrosis, or microvascular proliferation are not seen (Luxol fast blue stain, ×50). B, A higher power reveals variously shaped vacuoles and variably sized cellular elements within the nodules. A few larger pleomorphic cellular elements are more evident in the lower nodule. Some tumor cells show an ambiguous neuronlike appearance (Luxol fast blue stain, ×100).

  • FIG 2.
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    FIG 2.

    T2-weighted and FLAIR images from the baseline (A and B) and 6.4-year follow-up (C and D) MR imaging of a representative patient with a right superior parietal lobule MVNT.

  • FIG 3.
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    FIG 3.

    Representative FLAIR images from the baseline (A) and the second (B) MR imaging of a patient with a left-frontal MVNT (segmented in green). C and D, Images corresponding to the MR imaging examinations shown in A and B, respectively, show what the segmentation volume window looks like in our PACS.

  • FIG 4.
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    FIG 4.

    Days since prior scan versus absolute (A) and percentage (B) volume changes since the prior scan across 110 follow-up scans. Note the trendline (blue) with the 95% confidence interval (gray areas).

  • FIG 5.
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    FIG 5.

    Days since first scan versus absolute (A) and percentage (B) volume changes since the first scan, across 110 follow-up scans. Note the trendline (blue) with the 95% confidence interval (gray areas).

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S. Dogra, D. Zagzag, M. Young, J. Golfinos, D. Orringer, R. Jain
Long-Term Follow-up of Multinodular and Vacuolating Neuronal Tumors and Implications for Surveillance Imaging
American Journal of Neuroradiology Jul 2023, DOI: 10.3174/ajnr.A7946

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Long-Term Follow-up of Multinodular and Vacuolating Neuronal Tumors and Implications for Surveillance Imaging
S. Dogra, D. Zagzag, M. Young, J. Golfinos, D. Orringer, R. Jain
American Journal of Neuroradiology Jul 2023, DOI: 10.3174/ajnr.A7946
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