Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Review ArticleReview Articles
Open Access

Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation

A. Agarwal, A.A. Bhatt, G. Bathla, S. Kanekar, N. Soni, J. Murray, K. Vijay, P. Vibhute and P.H. Rhyner
American Journal of Neuroradiology August 2023, DOI: https://doi.org/10.3174/ajnr.A7960
A. Agarwal
aFrom the Departments of Radiology (A.A., J.M., P.V., P.H.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Agarwal
A.A. Bhatt
bRadiology & Otolaryngology (A.A.B.), Mayo Clinic, Jacksonville, Florida
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.A. Bhatt
G. Bathla
cDepartment of Radiology (G.B.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Bathla
S. Kanekar
dPenn State University Health System (S.K.), Hershey, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S. Kanekar
N. Soni
eDepartment of Radiology (N.S.), University of Rochester Medical Center, Rochester, New York
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Soni
J. Murray
aFrom the Departments of Radiology (A.A., J.M., P.V., P.H.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Murray
K. Vijay
fDepartment of Radiology (K.V.), University of Texas Southwestern Medical Center, Dallas, Texas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Vibhute
aFrom the Departments of Radiology (A.A., J.M., P.V., P.H.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P. Vibhute
P.H. Rhyner
aFrom the Departments of Radiology (A.A., J.M., P.V., P.H.R.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.H. Rhyner
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    WHO Classification of Tumours Editorial Board. Head and neck tumours. Lyon (France): International Agency for Research on Cancer; 2022. WHO classification of tumours series, 5th ed. vol. 9. Available from: https://tumourclassification.iarc.who.int/chapters/52
  2. 2.↵
    1. El-Naggar AK,
    2. Chan JKC,
    3. Grandis JR
    , et al. WHO classification of head and neck tumours. Lyon (France): International Agency for Research on Cancer; 2017
  3. 3.↵
    1. Thompson LDR,
    2. Bishop JA
    . Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Nasal Cavity, Paranasal Sinuses and Skull Base. Head Neck Pathol 2022;16:1–18 doi:10.1007/s12105-021-01406-5 pmid:35312976
    CrossRefPubMed
  4. 4.↵
    1. Glöss S,
    2. Jurmeister P,
    3. Thieme A, et al
    . IDH2 R172 mutations across poorly differentiated sinonasal tract malignancies: forty molecularly homogenous and histologically variable cases with favorable outcome. Am J Surg Pathol 2021;45:1190–204 doi:10.1097/PAS.0000000000001697 pmid:34265800
    CrossRefPubMed
  5. 5.↵
    1. Alzumaili B,
    2. Sadow PM
    . IDH2-mutated sinonasal tumors: a review. Adv Anat Pathol 2023;30:104–11 doi:10.1097/PAP.0000000000000391 pmid:36537260
    CrossRefPubMed
  6. 6.↵
    1. Schultz KA,
    2. Williams GM,
    3. Kamihara J, et al
    . DICER1 and associated conditions: identification of at-risk individuals and recommended surveillance strategies. Clin Cancer Res 2018;24:2251–61 doi:10.1158/1078-0432.CCR-17-3089 pmid:29343557
    Abstract/FREE Full Text
  7. 7.↵
    1. Lee JT,
    2. Garg R,
    3. Brunworth J, et al
    . Sinonasal respiratory epithelial adenomatoid hamartomas: series of 51 cases and literature review. Am J Rhinol Allergy 2013;27:322–28 doi:10.2500/ajra.2013.27.3905 pmid:23883815
    CrossRefPubMed
  8. 8.↵
    1. Dean KE,
    2. Shatzkes D,
    3. Phillips CD
    . Imaging review of new and emerging sinonasal tumors and tumor-like entities from the Fourth Edition of the World Health Organization Classification of Head and Neck Tumors. AJNR Am J Neuroradiol 2019;40:584–90 doi:10.3174/ajnr.A5978 pmid:30765377
    Abstract/FREE Full Text
  9. 9.↵
    1. Fleming KE,
    2. Perez-Ordoñez B,
    3. Nasser JG, et al
    . Sinonasal seromucinous hamartoma: a review of the literature and a case report with focal myoepithelial cells. Head Neck Pathol 2012;6:395–99 doi:10.1007/s12105-012-0339-6 pmid:22392408
    CrossRefPubMed
  10. 10.↵
    1. Guillerman RP,
    2. Foulkes WD,
    3. Priest JR
    . Imaging of DICER1 syndrome. Pediatr Radiol 2019;49:1488–505 doi:10.1007/s00247-019-04429-x pmid:31620849
    CrossRefPubMed
  11. 11.↵
    1. Mason K,
    2. Navaratnam A,
    3. Theodorakopoulou E, et al
    . Nasal chondromesenchymal hamartoma (NCMH): a systematic review of the literature with a new case report. J Otolaryngol Head Neck Surg 2015;44:28 doi:10.1186/s40463-015-0077-3 pmid:26138824
    CrossRefPubMed
  12. 12.↵
    1. Vorasubin N,
    2. Vira D,
    3. Suh JD, et al
    . Schneiderian papillomas: comparative review of exophytic, oncocytic, and inverted types. Am J Rhinol Allergy 2013;27:287–92 doi:10.2500/ajra.2013.27.3904 pmid:23883810
    CrossRefPubMed
  13. 13.↵
    1. Jeon TY,
    2. Kim HJ,
    3. Chung SK, et al
    . Sinonasal inverted papilloma: value of convoluted cerebriform pattern on MR imaging. AJNR Am J Neuroradiol 2008;29:1556–60 doi:10.3174/ajnr.A1128 pmid:18499786
    CrossRefPubMed
  14. 14.↵
    1. Yang B,
    2. Li J,
    3. Dong J
    . MR imaging and CT features of oncocytic papilloma of the sinonasal tract with comparison to inverted papilloma. Br J Radiol 2018;91:20170957 doi:10.1259/bjr.20170957 pmid:29987980
    CrossRefPubMed
  15. 15.↵
    1. Buchwald C,
    2. Franzmann MB,
    3. Tos M
    . Sinonasal papillomas: a report of 82 cases in Copenhagen County, including a longitudinal epidemiological and clinical study. Laryngoscope 1995;105:72–79 doi:10.1288/00005537-199501000-00016 pmid:7837917
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Glâtre R,
    2. De Kermadec H,
    3. Alsamad IA, et al
    . Exophytic sinonasal papillomas and nasal florid papillomatosis: a retrospective study. Head Neck 2018;40:740–46 doi:10.1002/hed.25042 pmid:29341451
    CrossRefPubMed
  17. 17.↵
    1. Raghavan P,
    2. Phillips CD
    . Magnetic resonance imaging of sinonasal malignancies. Top Magn Reson Imaging 2007;18:259–67 doi:10.1097/RMR.0b013e31815711b7 pmid:17893591
    CrossRefPubMed
  18. 18.↵
    1. Agger A,
    2. von Buchwald C,
    3. Madsen AR, et al
    . Squamous cell carcinoma of the nasal vestibule 1993-2002: a nationwide retrospective study from DAHANCA. Head Neck 2009;31:1593–99 doi:10.1002/hed.21132 pmid:19475548
    CrossRefPubMed
  19. 19.↵
    1. Ansa B,
    2. Goodman M,
    3. Ward K, et al
    . Paranasal sinus squamous cell carcinoma incidence and survival based on surveillance, epidemiology, and end results data, 1973 to 2009. Cancer 2013;119:2602–10 doi:10.1002/cncr.28108 pmid:23674262
    CrossRefPubMed
  20. 20.↵
    1. Lee T,
    2. Cho J,
    3. Baek CH, et al
    . Prevalence of NUT carcinoma in head and neck: analysis of 362 cases with literature review. Head Neck 2020;42:924–38 doi:10.1002/hed.26067 pmid:31903701
    CrossRefPubMed
  21. 21.↵
    1. Edgar M,
    2. Caruso AM,
    3. Kim E, et al
    . NUT midline carcinoma of the nasal cavity. Head Neck Pathol 2017;11:389–92 doi:10.1007/s12105-016-0763-0 pmid:27757815
    CrossRefPubMed
  22. 22.↵
    1. Shatzkes DR,
    2. Ginsberg LE,
    3. Wong M, et al
    . Imaging appearance of SMARCB1 (INI1)-deficient sinonasal carcinoma: a newly described sinonasal malignancy. AJNR Am J Neuroradiol 2016;37:1925–29 doi:10.3174/ajnr.A4841 pmid:27390322
    Abstract/FREE Full Text
  23. 23.↵
    1. Bishop JA,
    2. Ogawa T,
    3. Stelow EB, et al
    . Human papillomavirus-related carcinoma with adenoid cystic-like features: a peculiar variant of head and neck cancer restricted to the sinonasal tract. Am J Surg Pathol 2013;37:836–44 doi:10.1097/PAS.0b013e31827b1cd6 pmid:23598962
    CrossRefPubMed
  24. 24.↵
    1. Bishop JA,
    2. Andreasen S,
    3. Hang JF, et al
    . HPV-related multiphenotypic sinonasal carcinoma: an expanded series of 49 cases of the tumor formerly known as HPV-related carcinoma with adenoid cystic carcinoma-like features. Am J Surg Pathol 2017;41:1690–701 doi:10.1097/PAS.0000000000000944 pmid:28877065
    CrossRefPubMed
  25. 25.↵
    1. Leivo I
    . Sinonasal adenocarcinoma: update on classification, immunophenotype and molecular features. Head Neck Pathol 2016;10:68–74 doi:10.1007/s12105-016-0694-9 pmid:26830399
    CrossRefPubMed
  26. 26.↵
    1. Eggesbø HB
    . Imaging of sinonasal tumours. Cancer Imaging 2012;12:136–52 doi:10.1102/1470-7330.2012.0015 pmid:22571851
    CrossRefPubMed
  27. 27.↵
    1. Dublin AB,
    2. Bobinski M
    . Imaging characteristics of olfactory neuroblastoma (esthesioneuroblastoma). J Neurol Surg B Skull Base 2016;77:1–5 doi:10.1055/s-0035-1564053 pmid:26949582
    CrossRefPubMed
  28. 28.↵
    1. Rostomily RC,
    2. Elias M,
    3. Deng M, et al
    . Clinical utility of somatostatin receptor scintigraphic imaging (octreoscan) in esthesioneuroblastoma: a case study and survey of somatostatin receptor subtype expression. Head Neck 2006;28:305–12 doi:10.1002/hed.20356 pmid:16470879
    CrossRefPubMed
  29. 29.↵
    1. Magill JC,
    2. Ferguson MS,
    3. Sandison A, et al
    . Nasal craniopharyngioma: case report and literature review. J Laryngol Otol 2011;125:517–19 doi:10.1017/S0022215110002938 pmid:21255479
    CrossRefPubMed
  30. 30.↵
    1. Yu X,
    2. Liu R,
    3. Wang Y, et al
    . Infrasellar craniopharyngioma. Clin Neurol Neurosurg 2012;114:112–19 doi:10.1016/j.clineuro.2011.09.010 pmid:22018920
    CrossRefPubMed
  31. 31.↵
    1. Riobello C,
    2. López-Hernández A,
    3. Cabal VN, et al
    . IDH2 mutation analysis in undifferentiated and poorly differentiated sinonasal carcinomas for diagnosis and clinical management. Am J Surg Pathol 2020;44:396–405 doi:10.1097/PAS.0000000000001420 pmid:31876581
    CrossRefPubMed
  32. 32.↵
    1. Rooper LM,
    2. Agaimy A,
    3. Dickson BC, et al
    . DEK-AFF2 carcinoma of the sinonasal region and skull base: detailed clinicopathologic characterization of a distinctive entity. Am J Surg Pathol 2021;45:1682–93 doi:10.1097/PAS.0000000000001741 pmid:34049316
    CrossRefPubMed
  33. 33.↵
    1. Bishop JA,
    2. Gagan J,
    3. Paterson C, et al
    . Nonkeratinizing squamous cell carcinoma of the sinonasal tract with DEK-AFF2: further solidifying an emerging entity. Am J Surg Pathol 2021;45:718–20 doi:10.1097/PAS.0000000000001596 pmid:33002918
    CrossRefPubMed
  34. 34.↵
    1. Nosé V
    . Genodermatosis affecting the skin and mucosa of the head and neck: clinicopathologic, genetic, and molecular aspect–PTEN-hamartoma tumor syndrome/Cowden syndrome. Head Neck Pathol 2016;10:131–38 doi:10.1007/s12105-016-0708-7 pmid:26975628
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
A. Agarwal, A.A. Bhatt, G. Bathla, S. Kanekar, N. Soni, J. Murray, K. Vijay, P. Vibhute, P.H. Rhyner
Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation
American Journal of Neuroradiology Aug 2023, DOI: 10.3174/ajnr.A7960

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Update from the 5th Edition of the WHO Classification of Nasal, Paranasal, and Skull Base Tumors: Imaging Overview with Histopathologic and Genetic Correlation
A. Agarwal, A.A. Bhatt, G. Bathla, S. Kanekar, N. Soni, J. Murray, K. Vijay, P. Vibhute, P.H. Rhyner
American Journal of Neuroradiology Aug 2023, DOI: 10.3174/ajnr.A7960
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • CONCLUSIONS
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Arteries
  • An Atlas of Neonatal Neurovascular Imaging Anatomy as Depicted with Microvascular Imaging: The Intracranial Veins
  • Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging
Show more Review Articles

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire