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Research ArticleNEUROIMAGING PHYSICS/FUNCTIONAL NEUROIMAGING/CT AND MRI TECHNOLOGY
Open Access

Compatibility of Standard Vagus Nerve Stimulation and Investigational Microburst Vagus Nerve Stimulation Therapy with fMRI

Erik H. Middlebrooks, Jerzy P. Szaflarski, Jason Begnaud, Ashesh Thaker, Kenny Henderson, Mark Bolding, Jill A. Sellers and Jane Allendorfer
American Journal of Neuroradiology May 2024, DOI: https://doi.org/10.3174/ajnr.A8235
Erik H. Middlebrooks
aFrom the Department of Neuroradiology (E.H.M.), Mayo Clinic College of Medicine and Science, Jacksonville, Florida
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Jerzy P. Szaflarski
bDepartment of Neurology (J.P.S., M.B., J.A.), Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
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Jason Begnaud
cNeuromodulation Division (J.B., K.H.), LivaNova USA, Houston, Texas
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Ashesh Thaker
dDepartmentd of Neuroradiology (A.T.) and Radiology, Denver Health, University of Colorado School of Medicine, Denver, Colorado
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  • ORCID record for Ashesh Thaker
Kenny Henderson
cNeuromodulation Division (J.B., K.H.), LivaNova USA, Houston, Texas
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Mark Bolding
bDepartment of Neurology (J.P.S., M.B., J.A.), Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
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Jill A. Sellers
eSellers Communications LLC (J.A.S.), Springfield, Missouri
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Jane Allendorfer
bDepartment of Neurology (J.P.S., M.B., J.A.), Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama
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    FIG 1.

    Implanted VNS device. The pulse generator is implanted in the left chest, and the lead is connected to the left vagus nerve in the neck. VNS pulses are delivered to the brain via the vagus nerve. Adapted with permission from Verner et al.3

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    FIG 2.

    Exclusion zone and permissible area during MR imaging for the head and extremity using local transmit/receive head or extremity coils. RF indicates radiofrequency.

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    FIG 3.

    Exclusion zone and permissible area during MR imaging for the body using the body-transmit coil and the local receive-only coil.

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    FIG 4.

    Microburst participant accountability showing the initial enrollment through study completion plus study attrition.

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Cite this article
Erik H. Middlebrooks, Jerzy P. Szaflarski, Jason Begnaud, Ashesh Thaker, Kenny Henderson, Mark Bolding, Jill A. Sellers, Jane Allendorfer
Compatibility of Standard Vagus Nerve Stimulation and Investigational Microburst Vagus Nerve Stimulation Therapy with fMRI
American Journal of Neuroradiology May 2024, DOI: 10.3174/ajnr.A8235

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Compatibility of Standard Vagus Nerve Stimulation and Investigational Microburst Vagus Nerve Stimulation Therapy with fMRI
Erik H. Middlebrooks, Jerzy P. Szaflarski, Jason Begnaud, Ashesh Thaker, Kenny Henderson, Mark Bolding, Jill A. Sellers, Jane Allendorfer
American Journal of Neuroradiology May 2024, DOI: 10.3174/ajnr.A8235
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