Research ArticleORIGINAL RESEARCH
Predicting White Matter Hyperintensity: Leveraging Portable Magnetic Resonance Imaging for Accessible Brain Health Screening
Ian P. Johnson, Hailey Brigger, Joel Smith, Emma Peasley, Alison Champagne, Lauren Littig, Dheeraj Lalwani, Gordon Sze, Seyedmehdi Payabvash, Basmah Safdar, Gail D’Onofrio, Charles Wira, Juan Eugenio Iglesias, Matthew S. Rosen, Annabel Sorby-Adams, W. Taylor Kimberly, Kevin N. Sheth and Adam de Havenon
American Journal of Neuroradiology March 2025, ajnr.A8734; DOI: https://doi.org/10.3174/ajnr.A8734
Ian P. Johnson
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Hailey Brigger
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Joel Smith
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Emma Peasley
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Alison Champagne
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Lauren Littig
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Dheeraj Lalwani
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Gordon Sze
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Seyedmehdi Payabvash
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Basmah Safdar
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Gail D’Onofrio
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Charles Wira
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Juan Eugenio Iglesias
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Matthew S. Rosen
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Annabel Sorby-Adams
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
W. Taylor Kimberly
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Kevin N. Sheth
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
Adam de Havenon
From the Department of Neurology (I.P.J, H.B, J.S, E.P, A.C, L.L, D.L, K.N.S, A.D), Department of Radiology (G.S, S.P), and Department of Emergency Medicine (G.D, C.W), Yale School of Medicine, New Haven, CT, USA; Department of Neurology (A.S, W.T.K), Center for Genomic Medicine (A.S, W.T.K), and Athinoula A. Martinos Center for Biomedical Imaging (J.E.I, M.S.R), Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Centre for Medical Image Computing (J.E.I), University College London, London, UK; Computer Science and Artificial Intelligence Laboratory (J.E.I), Massachusetts Institute of Technology, Cambridge, MA, USA.
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Accepted Manuscript
Ian P. Johnson, Hailey Brigger, Joel Smith, Emma Peasley, Alison Champagne, Lauren Littig, Dheeraj Lalwani, Gordon Sze, Seyedmehdi Payabvash, Basmah Safdar, Gail D’Onofrio, Charles Wira, Juan Eugenio Iglesias, Matthew S. Rosen, Annabel Sorby-Adams, W. Taylor Kimberly, Kevin N. Sheth, Adam de Havenon
Predicting White Matter Hyperintensity: Leveraging Portable Magnetic Resonance Imaging for Accessible Brain Health Screening
American Journal of Neuroradiology Mar 2025, ajnr.A8734; DOI: 10.3174/ajnr.A8734
Accepted Manuscript
Predicting White Matter Hyperintensity: Leveraging Portable Magnetic Resonance Imaging for Accessible Brain Health Screening
Ian P. Johnson, Hailey Brigger, Joel Smith, Emma Peasley, Alison Champagne, Lauren Littig, Dheeraj Lalwani, Gordon Sze, Seyedmehdi Payabvash, Basmah Safdar, Gail D’Onofrio, Charles Wira, Juan Eugenio Iglesias, Matthew S. Rosen, Annabel Sorby-Adams, W. Taylor Kimberly, Kevin N. Sheth, Adam de Havenon
American Journal of Neuroradiology Mar 2025, ajnr.A8734; DOI: 10.3174/ajnr.A8734
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