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The authors enrolled 10 patients with intracranial aneurysms, treated with flow diverters between September 2014 and December 2018, who experienced postoperative aneurysm rupture. They matched these subjects 1:2 with 20 with postoperative unruptured intracranial aneurysms based on clinical and morphologic factors. Using computational fluid dynamics, they assessed hemodynamic changes pre- and posttreatment between the 2 groups on a number of qualitative and quantitative parameters. Compared with pretreatment, unstable flow pattern and higher energy loss after Pipeline Embolization Device placement for intracranial aneurysm may be the important hemodynamic risk factors related to delayed aneurysm rupture.