- Dynamic Expansion and Contraction of Multiple Sclerosis T2-Weighted Hyperintense Lesions Are Present below the Threshold of Visual Perception
Recognition of longitudinal imaging changes of MS lesions has substantial implications for clinical management, but changes may remain below the resolution of human perception. In this study, the authors demonstrated that T2-weighted hyperintense lesions undergo dynamic change on MRI, with predominantly enlarging or contracting characteristics, more frequently seen in untreated individuals.
- Macro- and Microstructural White Matter Differences in Neurologic Postacute Sequelae of SARS-CoV-2 Infection
In this cross-sectional study, SARS-CoV-2 infection effects on GM/WM volume, WM microstructure, cognitive performance, and peripheral cytokine concentrations were investigated. The study found that the NeuroPASC group had larger global and regional (prefrontal cortex and hippocampus) cerebral WM volume, more self-reported PASC symptoms, more headaches, lower psychometric performance, widespread higher mean kurtosis in WM microstructure, and different cytokine concentration profiles compared with controls. The authors conclude that immune dysregulation following SARS-CoV-2 infection might result in cerebral WM macrostructural and microstructural injury causing NeuroPASC clinical signs and symptoms.
- Radiologic Classification of Hippocampal Sclerosis in Epilepsy
This review explores how the International League Against Epilepsy (ILAE) subtypes of hippocampal sclerosis correlate with MRI findings. Hippocampal anatomy is reviewed in detail. The pathophysiology of hippocampal sclerosis is discussed. A radiologic classification scheme is proposed that aligns with the ILAE pathology classification, aiming to improve clinical communication and decision-making.
- Multiparametric Characterization and Spatial Distribution of Different MS Lesion Phenotypes
Lesion phenotype (ie, different levels of axonal and myelin loss and spatial distribution) was characterized using quantitative susceptibility mapping, susceptibility-weighted imaging, T1-relaxometry, myelin mapping, and diffusion MRI. A more severe disease course was observed in hyperintense and paramagnetic rim lesions in the periventricular white matter.
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