Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple Sclerosis

A and B, Mean (per patient) lesional MTR versus NAA/Cr for the entire cohort of patients with MS (A) and the relapsing-remitting subgroup (B) (circles indicate relapsing-remitting group; plus signs, primary progressive; diamonds, secondary progressive). Linear regression lines are plotted for both data sets, but the correlation was significant only for the relapsing-remitting subgroup (solid line in B; r_S = .70; P = .016)

A and B, Mean (per patient) MTR versus NAA/Cr in new lesions (<6 months old) for the entire cohort of patients with MS (A) and the relapsing-remitting subgroup (B) (circles indicate relapsing-remitting group; plus signs, primary progressive; diamonds, secondary progressive). The solid lines represent the linear regressions, and the corresponding rank correlations were r_S = .44, P = .015 (A) and r_S = .81, P = .002 (B)