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Research ArticleBRAIN

Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular Dementia

Jody L. Tanabe, Frank Ezekiel, William J. Jagust, Bruce R. Reed, David Norman, Norbert Schuff, Michael W. Weiner, Helena Chui and George Fein
American Journal of Neuroradiology May 1999, 20 (5) 839-844;
Jody L. Tanabe
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Frank Ezekiel
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William J. Jagust
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Bruce R. Reed
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David Norman
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Norbert Schuff
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Michael W. Weiner
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Helena Chui
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George Fein
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    fig 1.

    A–C, A, Proton density–weighted section from a subject with extensive WMSH; B, corresponding segmentation section showing different tissue classes (WMSH in black); C, color-coded map of MTR of WMSH (green corresponds to lowest MTR and yellow to highest MTR, shown in the color bar); and D, a sample of periventricular WMSH (black line, defined as those pixels representing the overlap between WMSH and a two-pixel region grown of ventricular space but excluding all partial volumed pixels (see Methods for details)

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    fig 2.

    MTR of periventricular and nonperiventricular WMSH for control subjects and patients with SIVD. Values are mean ± 1 SD; P values are before correction of the percentage of WMSH

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    fig 3.

    The effect of group and percentage of WMSH on the MTR of periventricular WMSH. Control subjects indicated by filled circles, SIVD patients by open circles.

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    fig 4.

    Plot showing no correlation between lesion size and MTR of that lesion for either control subjects or patients with SIVD. Control subjects indicated by filled circles, SIVD patients by open circles.

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    TABLE 1:

    Demographic data for healthy control subjects and subjects with subcortical ischemic vascular dementia (SIVD)

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    TABLE 2:

    Magnetization transfer ratio (MTR) of various tissue classes in healthy control subjects and subjects with subcortical ischemic vascular dementia (SIVD)

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    TABLE 3:

    Tissue contribution in healthy control subjects and subjects with subcortical ischemic vascular dementia (SIVD)

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American Journal of Neuroradiology
Vol. 20, Issue 5
1 May 1999
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Jody L. Tanabe, Frank Ezekiel, William J. Jagust, Bruce R. Reed, David Norman, Norbert Schuff, Michael W. Weiner, Helena Chui, George Fein
Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular Dementia
American Journal of Neuroradiology May 1999, 20 (5) 839-844;

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Magnetization Transfer Ratio of White Matter Hyperintensities in Subcortical Ischemic Vascular Dementia
Jody L. Tanabe, Frank Ezekiel, William J. Jagust, Bruce R. Reed, David Norman, Norbert Schuff, Michael W. Weiner, Helena Chui, George Fein
American Journal of Neuroradiology May 1999, 20 (5) 839-844;
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