Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Other Publications
    • ajnr

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • AJNR Case Collection
    • Case of the Week Archive
    • Classic Case Archive
    • Case of the Month Archive
  • Special Collections
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
    • 2024 AJNR Journal Awards
    • Most Impactful AJNR Articles
  • Multimedia
    • AJNR Podcast
    • AJNR Scantastics
    • Video Articles
  • For Authors
    • Submit a Manuscript
    • Author Policies
    • Fast publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Manuscript Submission Guidelines
    • Imaging Protocol Submission
    • Submit a Case for the Case Collection
  • About Us
    • About AJNR
    • Editorial Board
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

Welcome to the new AJNR, Updated Hall of Fame, and more. Read the full announcements.


AJNR is seeking candidates for the position of Associate Section Editor, AJNR Case Collection. Read the full announcement.

 

Research ArticleBRAIN

MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis

Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan and Robert M. Quencer
American Journal of Neuroradiology April 2000, 21 (4) 647-658;
Brian C. Bowen
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pradip M. Pattany
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Walter G. Bradley
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James B. Murdoch
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francisco Rotta
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akmal A. Younis
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert C. Duncan
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert M. Quencer
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. ↵
    Nelson LM. Epidemiology of ALS. Clin Neurosci 1996;3:327-331
    CrossRef
  2. ↵
    Leigh PN. Pathogenic mechanisms in amyotrophic lateral sclerosis and other motor neuron disorders. In: Calne DB, ed Neurodegenerative Diseases Philadelphia: Saunders; 1993:473-488
  3. ↵
    Brooks BR, Antel J, Bradley WG. El Escorial World Federation of Neurology Criteria for the diagnosis of amyotrophic lateral sclerosis. Neurol Sci 1994;124:96-107
  4. ↵
    Oba H, Araki T, Ohtomo K, et al. Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology 1993;189:843-846
    CrossRefPubMedWeb of Science
  5. ↵
    Cheung G, Gawel MJ, Cooper PW, et al. Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology 1995;194:263-270
    CrossRefPubMedWeb of Science
  6. Hofman E, Ochs G, Pelzl A, Warmuth-Methz M. The corticospinal tract in amyotrophic lateral sclerosis: an MRI study. Neuroradiology 1998;40:71-75
    CrossRefPubMedWeb of Science
  7. ↵
    Waragai M. MRI and clinical features in amyotrophic lateral sclerosis. Neuroradiology 1997;39:847-851
    CrossRefPubMedWeb of Science
  8. ↵
    Hajnal JV, Bryant DJ, Kasuboski L, et al. Use of fluid attenuated inversion recovery (FLAIR) pulse sequences in MRI of the brain. J Comput Assist Tomogr 1992;16:841-844
    CrossRefPubMedWeb of Science
  9. ↵
    Pioro EP, Antel JP, Cashman NR, Arnold DL. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo. Neurology 1994;44:1933-1938
    Abstract/FREE Full Text
  10. Jones AP, Gunawardena WJ, Coutinho CM, et al. Preliminary results of proton magnetic resonance spectroscopy in motor neurone disease (amyotrophic lateral sclerosis). J Neurol Sci 1995;129: Suppl: 85-89
    CrossRefPubMed
  11. ↵
    Block W, Karitzky J, Traber F, et al. Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch Neurol 1998;55:931-366
    CrossRefPubMedWeb of Science
  12. ↵
    Rooney WD, Miller RG, Gelinas D, et al. Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology 1998;50:1800-1805
    Abstract/FREE Full Text
  13. ↵
    Gredal O, Rosenbaum S, Topp S, et al. Quantification of brain metabolites in amyotrophic lateral sclerosis by localized proton magnetic resonance spectroscopy. Neurology 1997;48:878-881
    Abstract/FREE Full Text
  14. ↵
    Hammer RP Jr, Tomiyasu U, Scheibel AB. Degeneration of the human Betz cell due to amyotrophic lateral sclerosis. Exp Neurol 1979;63:336-346
    CrossRefPubMedWeb of Science
  15. ↵
    Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic pathway for neurologic disorders. N Engl J Med 1994;330:613-622
    CrossRefPubMedWeb of Science
  16. ↵
    Rothstein JD. Excitotoxicity and neurodegeneration in amyotrophic lateral sclerosis. Clin Neurosci 1996;3:348-359
    Web of Science
  17. Mitsumoto H, Chad DA, Pioro EP. Excitotoxicity and oxidative damage in ALS pathogenesis. In: Amyotrophic Lateral Sclerosis. Philadelphia: Davis; 1998:197-225
  18. ↵
    Haselgrove JC, Subramanian VH, Christen R, Leigh JS. Analysis of in-vivo NMR spectra. Rev Magn Reson Med 1987;2:167-222
  19. Bowen BC, Block RE, Sanchez-Ramos J, et al. Proton MR spectroscopy of the brain in 14 patients with Parkinson disease. AJNR Am J Neuroradiol 1995;16:61-68
    Abstract
  20. ↵
    Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679
    CrossRefPubMedWeb of Science
  21. ↵
    Michaelis T, Merboldt K-D, Bruhn H, et al. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 1993;187:219-227
    CrossRefPubMedWeb of Science
  22. ↵
    Pouwels PJW, Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn Reson Med 1998;39:53-60
    CrossRefPubMedWeb of Science
  23. ↵
    Pioro EP. MR spectroscopy in amyotrophic lateral sclerosis/motor neuron disease. J Neurol Sci 1997;152(Suppl 1):S49-S53
  24. ↵
    Naidich TP, Grant JL, Altman N, et al. The developing cerebral surface: preliminary report on the patterns of sulcal and gyral maturation—anatomy, ultrasound and magnetic resonance imaging. Neuroimaging Clin N Am 1994;4:201-240
    PubMed
  25. ↵
    Klose U. In vivo proton spectroscopy in the presence of eddy currents. Magn Reson Med 1990;14:26-30
    CrossRefPubMedWeb of Science
  26. ↵
    Miller BL. A review of chemical issues in 1H NMR spectroscopy: N-acetyl->/SCAP<L-aspartate, creatine and choline. NMR Biomed 1991;4:47-52
    PubMedWeb of Science
  27. ↵
    Rothstein JD, Tsai G, Kuncl RW, et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:18-25
    CrossRefPubMedWeb of Science
  28. ↵
    Tsai G, Stauch-Slusher B, Sim L, et al. Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain Res 1991;556:151-156
    CrossRefPubMedWeb of Science
  29. ↵
    Kalra S, Cashman NR, Genge A, Arnold DL. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 1998;9:1757-1761
    CrossRefPubMedWeb of Science
  30. ↵
    Ikeda K, Iwasaki Y, Kinoshita M, et al. Quantification of brain metabolites in ALS by localized proton magnetic spectroscopy (letter). Neurology 1998;50:576-577
    FREE Full Text
  31. ↵
    Doyle TJ, Bedell BJ, Narayana PA. Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain. Magn Reson Med 1995;33:755-759
    CrossRefPubMedWeb of Science
  32. ↵
    Petroff OA, Spencer DD, Alger JR, Prichard JW. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 1989;39:1197-1202
    Abstract/FREE Full Text
  33. ↵
    Klivenyi P, Ferrante RJ, Matthews RT, et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat Med 1999;5:347-350
    CrossRefPubMedWeb of Science
  34. ↵
    Roser W, Hagberg G, Mader I, et al. Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter. Magn Reson Med 1995;33:811-817
    PubMedWeb of Science
  35. Chang L, Miller BL, McBride D, et al. Brain lesions in patients with AIDS: H-1 MR spectroscopy. Radiology 1995;197:525-531
    CrossRefPubMedWeb of Science
  36. ↵
    Dal Canto MC. Comparison of pathological alterations in ALS and a murine transgenic model: pathogenetic implications. Clin Neurosci 1996;3:332-337
  37. Nagy D, Kato T, Kushner PD. Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis. J Neurosci Res 1994;38:336-347
    CrossRefPubMedWeb of Science
  38. Kushner PD, Stephenson DT, Wright S. Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. J Neuropathol Exp Neurol 1991;50:263-277
    CrossRefPubMed
  39. ↵
    Brand A, Richter-Landsberg C, Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 1993;15:289-298
    CrossRefPubMedWeb of Science
  40. ↵
    Frahm J, Hanefeld F. Localized proton magnetic resonance spectroscopy of cerebral metabolites. Neuropediatrics 1996;27:64-69
    CrossRefPubMedWeb of Science
  41. ↵
    Michaelis T, Merboldt K-D, Hanicke W, et al. On the identification of cerebral metabolites in localized 1H NMR spectra of human brain in vivo. NMR Biomed 1991;4:90-98
    CrossRefPubMedWeb of Science
  42. ↵
    Plaitakis A. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: a hypothesis. Ann Neurol 1990;28:3-8
    CrossRefPubMedWeb of Science
  43. Rothstein JD, Kuncl R, Chaudhry V. Excitatory amino acids in amyotrophic lateral sclerosis: an update. Ann Neurol 1991;30:224-225
    CrossRefPubMedWeb of Science
  44. Perry TL, Hansen S, Jones K. Brain glutamate deficiency in amyotrophic lateral sclerosis. Neurology 1987;37:1845-1848
    Abstract/FREE Full Text
  45. Plaitakis A, Constantakakis E. Altered metabolism of excitatory amino acids, N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in amyotrophic lateral sclerosis. Brain Res Bull 1993;30:381-386
    CrossRefPubMed
  46. ↵
    Kvamme E, Schousboe A, Hertz L, et al. Developmental change of endogenous glutamate and gamma-glutamyl transferase in cultured cerebral cortical interneurons and cerebellar granule cells, and in mouse cerebral cortex and cerebellum in vivo. Neurochem Res 1985;10:993-1008
    CrossRefPubMedWeb of Science
  47. ↵
    Drayer BP. Imaging of the aging brain: II, pathologic conditions. Radiology 1988;166:797-806
    CrossRefPubMedWeb of Science
  48. ↵
    Ernst T, Chang L, Melchor R, Mehringer CM. Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Radiology 1997;203:829-836
    CrossRefPubMedWeb of Science
  49. Cwik VA, Hanstock CC, Allen PS, Martin WR. Estimation of brainstem neuronal loss in amyotrophic lateral sclerosis with in vivo proton magnetic resonance spectroscopy. Neurology 1998;50:72-77
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology
Vol. 21, Issue 4
1 Apr 2000
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan, Robert M. Quencer
MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis
American Journal of Neuroradiology Apr 2000, 21 (4) 647-658;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis
Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan, Robert M. Quencer
American Journal of Neuroradiology Apr 2000, 21 (4) 647-658;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Appendix
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis
  • A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis
  • Mesial Prefrontal Cortex Degeneration in Amyotrophic Lateral Sclerosis: A High-Field Proton MR Spectroscopy Study
  • Degeneration of the Mid-Cingulate Cortex in Amyotrophic Lateral Sclerosis Detected In Vivo with MR Spectroscopy
  • The Present and the Future of Neuroimaging in Amyotrophic Lateral Sclerosis
  • Diffusion anisotropy of the cervical cord is strictly associated with disability in amyotrophic lateral sclerosis
  • Quantitative objective markers for upper and lower motor neuron dysfunction in ALS
  • Cerebral degeneration predicts survival in amyotrophic lateral sclerosis
  • Objective tests for upper motor neuron involvement in amyotrophic lateral sclerosis (ALS)
  • Early detection and longitudinal changes in amyotrophic lateral sclerosis by 1H MRSI
  • Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Progression of Microstructural Damage in Spinocerebellar Ataxia Type 2: A Longitudinal DTI Study
  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editors Choice
  • Fellow Journal Club
  • Letters to the Editor

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • Special Collections

Resources

  • News and Updates
  • Turn around Times
  • Submit a Manuscript
  • Author Policies
  • Manuscript Submission Guidelines
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Submit a Case
  • Become a Reviewer/Academy of Reviewers
  • Get Peer Review Credit from Publons

Multimedia

  • AJNR Podcast
  • AJNR SCANtastic
  • Video Articles

About Us

  • About AJNR
  • Editorial Board
  • Not an AJNR Subscriber? Join Now
  • Alerts
  • Feedback
  • Advertise with us
  • Librarian Resources
  • Permissions
  • Terms and Conditions

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire