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Research ArticleBRAIN

Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine: A Study of MR Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy in Rat Brain Tumors

Tian Zhang, Akira Matsumura, Tetsuya Yamamoto, Fumiyo Yoshida, Tadao Nose and Nobuhiro Shimojo
American Journal of Neuroradiology January 2002, 23 (1) 15-18;
Tian Zhang
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Akira Matsumura
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Tetsuya Yamamoto
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Fumiyo Yoshida
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Tadao Nose
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Nobuhiro Shimojo
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References

  1. ↵
    Giovagnonia A, Paci E. Liver III: gadolinium based hepatobiliary contrast agents (Gd-EOB-DTPA and Gd-BOPTA/diemeg). Magn Reson Clin North Am 1996;4:61–72
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  3. Riccardo M, Giulia M, Richard LB, et al. Delayed MR imaging of hepatocellular carcinoma enhanced by gadobenate dimeglumine (Gd-BOPTA). J Magn Reson Imaging 1999;9:704–710
    CrossRefPubMed
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    Kuwatsuru R, Kadoya M, Ohtomo K, et al Clinical late phase III trials of multihance (Gd-BOPTA) for the magnetic resonance imaging of liver tumor in Japan. J Comput Assist Tomogr 1999;23(suppl 1):S65–S74
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    Spinazzi A, Lorusso V, Pirovano G, et al. Safety, tolerance, biodistribution, and MR imaging enhancement of the liver with gadobenate dimeglumine: results of clinical pharmacologic and pilot imaging studies in nonpatient and patient volunteers. Acad Radiol 1999;6:282–291
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    Kstdutani N, Sagami F, Tirone P, Morisetti A, Bussi S, Mandella RC. General toxicity study of gadobenate dimeglumine formulation (E7155) (4): 4-week repeated dose intravenous toxicity study followed by 4-week recovery period in dogs. J Toxicol Sci 1999;24(suppl 1):S41–S60
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    Okuda Y, Sagami F, Tirone P, Morisetti A, Bussi S, Masters RE. Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155)(4): study of embryo-fetal toxicity in rabbits by intravenous administration. J Toxicol Sci 1999;24(suppl 1):S79–S87
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    Mascalchi M, Jin XN, Agen C, et al. Ex-vivo MR imaging of liver intracellular contrast agents. Magn Reson Imaging 1997;15:469–474
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    Khokhlov VF, Yashkin PN, Silin DI, Djorova ES, Lawaczeck R. Neutron capture therapy with Gd-DTPA in tumor-bearing rats. In: Mishima Y, ed. Cancer Neutron Capture Therapy. New York, NY: Plenum Press; 1996:865–869
  10. Matsumura A, Shibata Y, Nakagawa K, et al. Boron-, gadolinium-porphyrin derivatives for neutron capture therapy. In: Mishima Y, ed. Cancer Neutron Capture Therapy. New York, NY: Plenum Press; 1996;245–251
  11. Hofmann B, Fischer C-O, Lawaczeck R, Platzek J, Semmler W. Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumor with the MRI contrast agent Gadobutrol. Invest Radiol 1999;34:126–133
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  12. Akine Y, Tokita N, Tokuuye K, et al. Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy. Jpn J Cancer Res 1993;84:841–843
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  13. Akine Y, Tokita N, Tokuuye K, Satoch M, Kobayashi T, Kanda K. Electron-equivalent dose for the effect of gadolinium neutron capture therapy on the growth of subcutaneously-inoculated Ehrlich tumor cells in mice. Jpn J Clin Oncol 1993;23:145–148
    Abstract/FREE Full Text
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    Akine Y, Tokita N, Matsumoto T, Oyama H, Egawa S, Aizawa O. Radiation effect of gadolinium neutron capture reactions on survival of Chinese hamster cells. Strahlenther Onkol 1990;166:831–833
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    Pascolo L, Capelli F, Anelli PL, et al. Molecular mechanisms for hepatic uptake of magnetic resonance imaging contrast agent. Biochem Biophys Res Comm 1999;257:746–7
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American Journal of Neuroradiology: 23 (1)
American Journal of Neuroradiology
Vol. 23, Issue 1
1 Jan 2002
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Cite this article
Tian Zhang, Akira Matsumura, Tetsuya Yamamoto, Fumiyo Yoshida, Tadao Nose, Nobuhiro Shimojo
Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine: A Study of MR Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy in Rat Brain Tumors
American Journal of Neuroradiology Jan 2002, 23 (1) 15-18;

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Comparison of Gadobenate Dimeglumine and Gadopentetate Dimeglumine: A Study of MR Imaging and Inductively Coupled Plasma Atomic Emission Spectroscopy in Rat Brain Tumors
Tian Zhang, Akira Matsumura, Tetsuya Yamamoto, Fumiyo Yoshida, Tadao Nose, Nobuhiro Shimojo
American Journal of Neuroradiology Jan 2002, 23 (1) 15-18;
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