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Research ArticlePEDIATRICS

Diffusion-Tensor Imaging for the Detection and Quantification of Treatment-Induced White Matter Injury in Children with Medulloblastoma: A Pilot Study

Pek-Lan Khong, Dora L. W. Kwong, Godfrey C. F. Chan, Jonathan S. T. Sham, Fu-Luk Chan and Gaik-Cheng Ooi
American Journal of Neuroradiology April 2003, 24 (4) 734-740;
Pek-Lan Khong
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Dora L. W. Kwong
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Godfrey C. F. Chan
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Jonathan S. T. Sham
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Fu-Luk Chan
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Gaik-Cheng Ooi
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References

  1. ↵
    Packer RJ, Goldwein J, Nicholson HS, et al. Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: a Children’s Cancer Group Study. J Clin Oncol 1999;17:2127–2136
    Abstract/FREE Full Text
  2. ↵
    Chan GCF, Li CK, Luk CW, et al. Treatment of childhood medulloblastoma with combined chemotherapy and craniospinal irradiation: the Hong Kong Experience. Neurooncology 2002 (abstract, in press)
  3. ↵
    Johnson DL, McCabe MA, Nicholson HS, et al. Quality of long-term survival in young children with medulloblastoma. J Neurosurg 1994;80:1004–1010
    CrossRefPubMedWeb of Science
  4. ↵
    Walter AW, Mulhern RK, Gajjar A, et al. Survival and neurodevelopmental outcome of young children with medulloblastoma at St. Jude Children’s Research Hospital. J Clin Oncol 1999;17:3720–3728
    Abstract/FREE Full Text
  5. ↵
    Packer RJ, Sposto R, Atkins TE, et al. Quality of life in children with primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Pediatr Neurosci 1987;13:169–175
    CrossRefPubMedWeb of Science
  6. ↵
    Silverman CL, Palkes H, Talent B, Kovnar E, Clouse JW, Thomas PRM. Late effects of radiotherapy on patients with cerebellar medulloblastoma. Cancer 1984;54:825–829
    CrossRefPubMed
  7. ↵
    Valk PE, Dillon WP. Radiation injury of the brain. AJNR Am J Neuroradiol 1991;12:45–62
    Abstract/FREE Full Text
  8. ↵
    Ball WS, Prenger EC, Ballard ET. Neurotoxicity of radio/chemotherapy in children: pathologic and MR correlation. AJNR Am J Neuroradiol 1992;13:761–776
    FREE Full Text
  9. Curran WJ, Hecht-Leavitt C, Schut L, Zimmerman RA, Nelson DF. Magnetic resonance imaging of cranial radiation lesions. Int J Radiat Oncol Biol Phys 1987;13:1093–1098
    PubMed
  10. Tsuruda JS, Kortman KE, Bradley WG, Wheeler DC, Van Dalsem W, Bradley TP. Radiation effects on cerebral white matter: MR evaluation. AJR Am J Roentgenol 1987;149:165–171
    PubMedWeb of Science
  11. ↵
    Constine LS, Konski A, Ekholm S, McDonald S, Rubin P. Adverse effects of brain irradiation correlated with MR and CT imaging. Int J Radiat Oncol Biol Phys 1988;15:319–330
    CrossRefPubMedWeb of Science
  12. Harila-Saari AH, Pääkkö EL, Vainionpää LK, Pyhtinen J, Lanning BM. A longitudinal magnetic resonance imaging study of the brain in survivors of childhood acute lymphoblastic leukemia. Cancer 1998;83:2608–2617
    CrossRefPubMedWeb of Science
  13. ↵
    Wilson DA, Nitschke R, Bowman ME, Chaffin MJ, Sexauer CL, Prince JR. Transient white matter changes on MRI images in children undergoing chemotherapy for acute lymphocytic leukemia: correlation with neuropsychologic deficiencies. Radiology 1991;180:205–209
    PubMedWeb of Science
  14. ↵
    Bihan DL, Mangin JF, Poupon C, et al. Diffusion tensor imaging: concepts and applications. J Magn Reson Imaging 2001;13:534–546
    CrossRefPubMedWeb of Science
  15. ↵
    Jones DK, Lythgoe D, Horsfield MA, Simmons A, Williams SCR, Markus HS. Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI. Stroke 1999;30:393–397
    Abstract/FREE Full Text
  16. ↵
    Sorensen AG, Wu O, Copen WA, et al. Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology 1999;212:785–792
    CrossRefPubMedWeb of Science
  17. ↵
    Guo AC, MacFall JR, Provenzale JM. Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology 2002;222:729–736
    PubMedWeb of Science
  18. ↵
    Ciccarelli O, Werring DJ, Wheeler-Kingshott CAM. Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations. Neurology 2001;56:926–933
    Abstract/FREE Full Text
  19. ↵
    Ito R, Melhem ER, Mori S, Eichler FS, Raymond GV, Moser HW. Diffusion tensor brain MR imaging in X-linked cerebral adrenoleukodystrophy. Neurology 2001;56:544–547
    Abstract/FREE Full Text
  20. ↵
    Guo AC, Petrella JR, Kurtzberg J, Provenzale JM. Evaluation of white matter anisotropy in Krabbe disease with diffusion tensor MR imaging: initial experience. Radiology 2001;218:809–815
    PubMedWeb of Science
  21. ↵
    Duffner PK, Horowitz ME, Krischer JP, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 1993;328:1725–1731
    CrossRefPubMedWeb of Science
  22. ↵
    Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed 1995;8:333–344
    CrossRefPubMedWeb of Science
  23. ↵
    Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–267
    CrossRefPubMedWeb of Science
  24. ↵
    Mulhern RK, Reddick WE, Palmer SL, et al. Neurocognitive deficits in medulloblastoma survivors and white matter loss. Ann Neurol 1999;46:834–841
    CrossRefPubMedWeb of Science
  25. ↵
    Rovaris M, Iannucci G, Falautano M, et al. Cognitive dysfunction in patients with mildly disabling relapsing-remitting multiple sclerosis: an exploratory study with diffusion tensor MR imaging. J Neurol Sci 2002;195:103–109
    CrossRefPubMedWeb of Science
  26. ↵
    Inoue T, Ogasawara K, Konno H, Ogawa A, Kabasawa H. Diffusion tensor imaging in patients with chronic brain ishcemia. Proc Intl Soc Magn Reson Med 2002;10
  27. ↵
    Chin HW, Maruyama Y. Age at treatment and long-term performance results in medulloblastoma. Cancer 1984;53:1952–1958
    CrossRefPubMedWeb of Science
  28. ↵
    Mulhern RK, Kepner JL, Thomas PR, Armstrong FD, Friedman HS, Kun LE. Neuropsychologic functioning of survivors of childhood medulloblastoma randomized to receive conventional or reduced-dose craniospinal irradiation: a pediatric oncology group study. J Clin Oncol 1998;16:1723–1728
    Abstract
  29. ↵
    Kimmings E, Kleinlugtebeld ATH. Medulloblastoma: factors influencing the educational potential of surviving children. Br J Neurosurg 1995;9:611–617
    PubMed
  30. ↵
    Hoppe-Hirsch E, Brunet L, Laroussinie F, et al. Intellectual outcome in children with malignant tumors of the posterior fossa: influence of the field of irradiation and quality of surgery. Childs Nerv Syst 1995;11:340–346
    CrossRefPubMedWeb of Science
  31. ↵
    Jankovic M, Brouwers P, Valsecci MG, et al. Association of 1800cGy cranial irradiation with intellectual function in children with acute lymphoblastic leukaemia. Lancet 1994;344:224–227
    CrossRefPubMedWeb of Science
  32. ↵
    Chan YL, Roebuck DJ, Yuen MP, et al. Long-term cerebral metabolite changes on proton magnetic resonance spectroscopy in patients cured of acute lymphoblastic leukemia with previous intrathecal methotrexate and cranial irradiation prophylaxis. Int J Radiat Oncol Biol Phys 2001;50:759–763
    CrossRefPubMedWeb of Science
  33. ↵
    Chan YL, Yeung DKW, Leung SF, Cao G. Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain. J Magn Reson Imaging 1999;10:130–137
    CrossRefPubMedWeb of Science
  34. ↵
    Davidson A, Tait DM, Payne GS, et al. Magnetic resonance spectroscopy in the evaluation of neurotoxicity following cranial irradiation for childhood cancer. Br J Radiol 2000;73:421–424
    Abstract
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American Journal of Neuroradiology: 24 (4)
American Journal of Neuroradiology
Vol. 24, Issue 4
1 Apr 2003
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Cite this article
Pek-Lan Khong, Dora L. W. Kwong, Godfrey C. F. Chan, Jonathan S. T. Sham, Fu-Luk Chan, Gaik-Cheng Ooi
Diffusion-Tensor Imaging for the Detection and Quantification of Treatment-Induced White Matter Injury in Children with Medulloblastoma: A Pilot Study
American Journal of Neuroradiology Apr 2003, 24 (4) 734-740;

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Diffusion-Tensor Imaging for the Detection and Quantification of Treatment-Induced White Matter Injury in Children with Medulloblastoma: A Pilot Study
Pek-Lan Khong, Dora L. W. Kwong, Godfrey C. F. Chan, Jonathan S. T. Sham, Fu-Luk Chan, Gaik-Cheng Ooi
American Journal of Neuroradiology Apr 2003, 24 (4) 734-740;
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Cited By...

  • Processing Speed, Attention, and Working Memory After Treatment for Medulloblastoma: An International, Prospective, and Longitudinal Study
  • Accelerated Aging, Decreased White Matter Integrity, and Associated Neuropsychological Dysfunction 25 Years After Pediatric Lymphoid Malignancies
  • Longitudinal Diffusion Tensor Magnetic Resonance Imaging Study of Radiation-Induced White Matter Damage in a Rat Model
  • White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function
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