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Research ArticleBRAIN

Focal Lesion in the Splenium of the Corpus Callosum on FLAIR MR Images: A Common Finding with Aging and after Brain Radiation Therapy

Joseph S. Pekala, Alexander C. Mamourian, Heather A. Wishart, William F. Hickey and James D. Raque
American Journal of Neuroradiology May 2003, 24 (5) 855-861;
Joseph S. Pekala
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Alexander C. Mamourian
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Heather A. Wishart
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William F. Hickey
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James D. Raque
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    Fig 1.

    Case of a 67-year-old patient imaged to rule out aneurysm.

    A, Axial and B, sagittal FLAIR MR images (10,000/156/1) show high signal intensity in the anterior subependymal region of the splenium of the corpus callosum, involving more than half the thickness (grade 2).

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    Fig 2.

    Case of a 32-year-old man (patient 12 in Table) with geminocystic astrocytoma.

    A, Axial FLAIR MR image (10,002/166/1) obtained 0.8 months before radiation therapy shows normal signal intensity in the splenium.

    B, Axial and C, sagittal FLAIR images (10,002/166/1) obtained 5.8 months after radiation therapy demonstrate a bright focus of abnormal signal intensity in the anterior subependymal region of the splenium of the corpus callosum (grade 2).

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    Fig 3.

    Two autopsy cases.

    A, Axial FLAIR (10,000/156/1) image obtained in a 63-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal region of the splenium.

    B, Photomicrograph of histologic specimen of the splenium (same patient as in A) demonstrates a band of isomorphic gliosis (hematoxylin and eosin stain; original magnification, x60).

    C, Axial FLAIR (10,000/156/1) image obtained in an 80-year-old man shows grade 1 signal intensity abnormality in the anterior subependymal region of the splenium.

    D, Photomicrograph of histologic specimen of the splenium (same patient as in C) shows no gliosis (hematoxylin and eosin stain; original magnification, x60).

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    TABLE 1:

    Summary of clinical and radiologic findings in the radiation therapy group

    Patient No.Age (y)/SexPretherapy FLAIR ImagesPosttherapy FLAIR Images
    Date (mo)*Splenium GradeWMD GradeDate (mo)*Splenium GradeWMD Grade
    153/FNA——4.821
    25/FNA——5.020
    335/F1.3008.220
    434/F1.0006.200
    564/M1.1216.221
    646/MNA——5.401
    755/M7018.221
    852/M1.10011.021
    954/MNA——11.321
    1043/M1.2009.421
    1150/M1.2008.520
    1232/M0.8005.821
    1350/MNA——10.021
    1462/M0.91011.821
    1553/MNA——3.221
    1657/FNA——4.021
    1753/M2.0005.221
    1857/FNA——5.921
    • Note.—WMD indicates white matter disease; NA, images not available.

    • * Indicates the number of months before or after radiation therapy that the FLAIR images were obtained.

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American Journal of Neuroradiology: 24 (5)
American Journal of Neuroradiology
Vol. 24, Issue 5
1 May 2003
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Cite this article
Joseph S. Pekala, Alexander C. Mamourian, Heather A. Wishart, William F. Hickey, James D. Raque
Focal Lesion in the Splenium of the Corpus Callosum on FLAIR MR Images: A Common Finding with Aging and after Brain Radiation Therapy
American Journal of Neuroradiology May 2003, 24 (5) 855-861;

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Focal Lesion in the Splenium of the Corpus Callosum on FLAIR MR Images: A Common Finding with Aging and after Brain Radiation Therapy
Joseph S. Pekala, Alexander C. Mamourian, Heather A. Wishart, William F. Hickey, James D. Raque
American Journal of Neuroradiology May 2003, 24 (5) 855-861;
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