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Research ArticleBRAIN

Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease

Haruo Hanyu, Soichiro Shimizu, Yuriko Tanaka, Masaru Takasaki, Kiyoshi Koizumi and Kimihiko Abe
American Journal of Neuroradiology August 2004, 25 (7) 1199-1204;
Haruo Hanyu
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Soichiro Shimizu
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Yuriko Tanaka
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Masaru Takasaki
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Kiyoshi Koizumi
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Kimihiko Abe
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    Fig 1.

    Statistical maps showing the relative decrease of rCBF in men with AD compared with that in control subjects (top) and in women with AD compared with that in control subjects (bottom).

    Although both patient groups show a notable decrease of rCBF in the parietotemporal lobes, posterior cingulate cortex, cinguloparietal transitional area, and frontal association cortices, men have a more severe reduction of rCBF in the parietal lobe and posterior cingulate cortex, and women have reduced rCBF in additional areas, including the frontal lobe and medial temporal regions. The color of the outer contour corresponds to a Z score of 7.

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    Fig 2.

    Statistical maps showing the relative decrease of rCBF in men with AD compared with that in women with AD (top) and in women with AD compared with that in men with AD (bottom).

    Men have a more severe decrease of rCBF in the parietooccipital and medial parietal lobes, whereas women have a more severe decrease of rCBF in the lateral, medial and orbital frontal lobes, and medial and inferior temporal regions. The color of the outer contour corresponds to a Z score of 7.

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    TABLE 1:

    Clinical characteristics of men and women with AD

    Men (n=30)Women (n=30)
    Age (years)75.9 (6.3)76.7 (7.6)
    Disease duration (years)3.1 (0.9)3.3 (0.8)
    Education (years)12.1 (3.6)11.5 (3.1)
    MMSE total score:19.3 (4.2)19.4 (3.6)
     Orientation5.7 (2.7)4.9 (2.3)
     Memory3.8 (1.1)3.7 (1.0)
     Attention and calculation1.5 (1.0)1.9 (1.7)
     Language6.6 (0.9)6.8 (0.5)
     Design copying0.7 (0.5)0.8 (0.3)
    • Note.—Values are mean (SD).

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    TABLE 2:

    MRI findings of men and women with AD

    Men (n=30)Women (n=30)
    White matter hyperintensity:
     Absent-punctate1817
     Early confluent910
     Confluent33
    Infarction (absent/present)19/1120/10
    Cortical atrophy1.9 (0.5)1.8 (0.6)
    Ventricular enlargement1.9 (0.7)1.6 (0.8)
    Medial temporal lobe atrophy2.4 (0.7)2.3 (0.8)
    • Note.—Values are mean (SD).

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American Journal of Neuroradiology: 25 (7)
American Journal of Neuroradiology
Vol. 25, Issue 7
1 Aug 2004
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Cite this article
Haruo Hanyu, Soichiro Shimizu, Yuriko Tanaka, Masaru Takasaki, Kiyoshi Koizumi, Kimihiko Abe
Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease
American Journal of Neuroradiology Aug 2004, 25 (7) 1199-1204;

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Differences in Regional Cerebral Blood Flow Patterns in Male versus Female Patients with Alzheimer Disease
Haruo Hanyu, Soichiro Shimizu, Yuriko Tanaka, Masaru Takasaki, Kiyoshi Koizumi, Kimihiko Abe
American Journal of Neuroradiology Aug 2004, 25 (7) 1199-1204;
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  • Altered Cerebral Blood Flow in Older Adults with Alzheimers Disease: A Systematic Review
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