Article Figures & Data
Figures
- Fig 1.
Color-coded areas (SPMt) of brain atrophy development in RRMS overlaid on a template T1-weighted image. All sections show extensive involvement of the ventricular system. Images A and B show involvement of the pericerebellar spaces and cerebellar tentorium. Images A, C, and D show involvement of the putamen; corpus callosum; insula; cingulate sulcus; and frontal, parietal, temporal, and occipital cortex.
- Fig 2.
Color-coded areas (SPMt) of brain atrophy development in SPMS overlaid on a template T1-weighted image. Image A shows the involvement of the bilateral anterior orbital gyrus and left mammillary body. B shows the involvement of the caudate nuclei; left middle temporal gyrus; left thalamus; and frontal, parietal, temporal and occipital region. C shows the involvement of the cingulate sulcus and regions of frontal and parietal cortex.
- Fig 3.
Color-coded areas (SPMt) of brain atrophy development in PPMS overlaid on a template T1-weighted image. A shows the involvement of the left middle occipital gyrus, bilateral parahippocampal gyri, and bilateral prepontine and quadrigeminal cisterns. B shows the involvement of the head of the left caudate nucleus, insula, and bilateral middle temporal gyrus. C shows the involvement of the bilateral central sulci (precentral and postcentral gyri) and regions of frontal and parietal cortex.
Tables
Demographic clinical characteristics and MR imaging findings at baseline and after 15 months
Healthy Subjects Patients RRMS SPMS PPMS M/F 4/6 8/12 6/13 12/19 Mean age (years) 42.6 (31–58) 35.9 (25–43) 49.3 (35–58) 50.1 (25–68) Median EDSS score NA 3.0 (0.0–5.0) 6.0 (4.0–8.0) 6.0 (2.5–7.0) Median disease duration (years) NA 5 (0–20) 16 (6–34) 10 (2–26) Baseline lesion volume (mL) On T2-weighted images NA 13.9 (10.6) 21.7 (17.3) 21.0 (16.9) On T1-weighted images NA 3.1 (3.6) 8.5 (7.3) 8.2 (6.9) Lesion volume change (%) On T2-weighted images NA 9.4 3.8 4.9 On T1-weighted images NA 3.4 11.0 4.3 Baseline NBV (mL) 1602 (80) 1517 (70) 1464 (90) 1473 (70) Note.—Data in parentheses are the range or standard deviation. NA indicates not applicable.
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