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Research ArticleBrain

Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype

Elisabetta Pagani, Maria A. Rocca, Antonio Gallo, Marco Rovaris, Vittorio Martinelli, Giancarlo Comi and Massimo Filippi
American Journal of Neuroradiology February 2005, 26 (2) 341-346;
Elisabetta Pagani
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Maria A. Rocca
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Antonio Gallo
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Marco Rovaris
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Vittorio Martinelli
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Giancarlo Comi
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Massimo Filippi
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References

  1. ↵
    Miller DH, Barkhof F, Frank JA, Parker GJ, Thompson AJ. Measurement of atrophy in multiple sclerosis: pathological basis, methodological aspects and clinical relevance [Review]. Brain 2002;125:1676–1695
    Abstract/FREE Full Text
  2. ↵
    Losseff NA, Wang L, Lai HM, et al. Progressive cerebral atrophy in multiple sclerosis. A serial MRI study. Brain 1996;119:2009–2019
    Abstract/FREE Full Text
  3. Stevenson VL, Miller DH, Rovaris M, et al. Primary and transitional progressive MS: a clinical and MRI cross-sectional study. Neurology 1999;52:839–845
    Abstract/FREE Full Text
  4. ↵
    Kalkers NF, Bergers E, Castelijns JA, et al. Optimizing the association between disability and biological markers in MS. Neurology 2001;57:1253–1258
    Abstract/FREE Full Text
  5. ↵
    De Stefano N, Narayanan S, Francis GS, et al. Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol 2001;58:65–70
    CrossRefPubMedWeb of Science
  6. De Stefano N, Iannucci G, Sormani MP, et al. MR correlates of cerebral atrophy in patients with multiple sclerosis. J Neurol 2002;249:1072–1077
    CrossRefPubMedWeb of Science
  7. De Stefano N, Matthews PM, Filippi M, et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 2003;60:1157–1162
    Abstract/FREE Full Text
  8. ↵
    Chard DT, Griffin CM, Parker GJ, Kapoor R, Thompson AJ, Miller DH. Brain atrophy in clinically early relapsing-remitting multiple sclerosis. Brain 2002;125:327–337
    Abstract/FREE Full Text
  9. ↵
    Dalton CM, Brex PA, Jenkins R, et al. Progressive ventricular enlargement in patients with clinically isolated syndromes is associated with the early development of multiple sclerosis. J Neurol Neurosurg Psychiatry 2002;73:141–147
    Abstract/FREE Full Text
  10. ↵
    Filippi M, Bozzali M, Rovaris M, et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 2003;126:433–437
    Abstract/FREE Full Text
  11. ↵
    Fisher E, Rudick RA, Cutter G, et al. Relationship between brain atrophy and disability: an 8-year follow-up study of multiple sclerosis patients. Mult Scler 2000;6:373–377
    Abstract/FREE Full Text
  12. ↵
    Rudick RA, Fisher E, Lee JC, Duda JT, Simon J. Brain atrophy in relapsing multiple sclerosis: relationship to relapses, EDSS, and treatment with interferon beta-1a. Mult Scler 2000;6:365–372
    Abstract/FREE Full Text
  13. ↵
    Zivadinov R, Sepcic J, Nasuelli D, et al. A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis. J Neurol Neurosurg Psychiatry 2001;70:773–780
    Abstract/FREE Full Text
  14. ↵
    Benedict RH, Bakshi R, Simon JH, Priore R, Miller C, Munschauer F. Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis. J Neuropsychiatry Clin Neurosci 2002;14:44–51
    CrossRefPubMedWeb of Science
  15. ↵
    Smith SM, De Stefano N, Jenkinson M, Matthews PM. Normalized accurate measurement of longitudinal brain change. J Comput Assist Tomogr 2001;25:466–475
    CrossRefPubMedWeb of Science
  16. ↵
    Liu C, Edwards S, Gong Q, Roberts N, Blumhardt LD. Three dimensional MRI estimates of brain and spinal cord atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 1999;66:323–330
    Abstract/FREE Full Text
  17. ↵
    Brex PA, Jenkins R, Fox NC, et al. Detection of ventricular enlargement in patients at the earliest clinical stage of MS. Neurology 2000;54:1689–1891
    Abstract/FREE Full Text
  18. ↵
    Dietemann JL, Beigelman C, Rumbach L, et al. Multiple sclerosis and corpus callosum atrophy: relationship of MRI findings to clinical data. Neuroradiology 1988;30:478–480
    CrossRefPubMedWeb of Science
  19. ↵
    Simon JH, Jacobs LD, Campion MK, et al. A longitudinal study of brain atrophy in relapsing multiple sclerosis: the Multiple Sclerosis Collaborative Research Group (MSCRG). Neurology 1999;53:139–148
    Abstract/FREE Full Text
  20. ↵
    Rovaris M, Inglese M, van Schijndel RA, et al. Sensitivity and reproducibility of volume change measurements of different brain portions on magnetic resonance imaging in patients with multiple sclerosis. J Neurol 2000;247:960–965
    CrossRefPubMedWeb of Science
  21. ↵
    Sailer M, Fischl B, Salat D, et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain 2003;126:1734–1744
    Abstract/FREE Full Text
  22. ↵
    Bakshi R, Benedict RH, Bermel RA, Jacobs L. Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship to clinical findings. J Neuroimaging 2001;11:129–136
    CrossRefPubMedWeb of Science
  23. ↵
    Ashburner J, Friston KJ. Voxel-based morphometry: the methods. NeuroImage 2000;11:805–821
    CrossRefPubMedWeb of Science
  24. ↵
    McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 2001;50:121–127
    CrossRefPubMedWeb of Science
  25. ↵
    Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444–1452
    Abstract/FREE Full Text
  26. ↵
    Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey: National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907–911
    Abstract/FREE Full Text
  27. ↵
    Thompson AJ, Montalban X, Barkhof F, et al. Diagnostic criteria for primary progressive multiple sclerosis: a position paper. Ann Neurol 2000;47:831–835
    CrossRefPubMedWeb of Science
  28. ↵
    Miller DH, Barkhof F, Berry I, Kappos L, Scotti G, Thompson AJ. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. J Neurol Neurosurg Psychiatry 1991;54:683–688
    Abstract/FREE Full Text
  29. ↵
    Rovaris M, Filippi M, Calori G, et al. Intra-observer reproducibility in measuring new putative MR markers of demyelination and axonal loss in multiple sclerosis: a comparison with conventional T2-weighted images. J Neurol 1997;244:266–270
    CrossRefPubMedWeb of Science
  30. ↵
    Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. NeuroImage 2002;17:479–489
    CrossRefPubMedWeb of Science
  31. ↵
    Duvernoy HM. The Human Brain: Surface, Blood Supply, and Three-Dimensional Sectional Anatomy. New York: Springer1999;1–491
  32. ↵
    Friston KJ, Holmes AP, Price CJ, et al. Multisubject fMRI studies and conjunction analyses. NeuroImage 1999;10:385–396
    CrossRefPubMedWeb of Science
  33. ↵
    Ge Y, Grossman RI, Udupa JK, et al. Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis. Radiology 2000;214:665–670
    PubMedWeb of Science
  34. ↵
    Inglese M, Rovaris M, Giacomotti L, Mastronardo G, Comi G, Filippi M. Quantitative brain volumetric analysis from patients with multiple sclerosis: a follow-up study. J Neurol Sci 1999;171:8–10
    CrossRefPubMedWeb of Science
  35. ↵
    Resnick SM, Goldszal AF, Davatzikos C, et al. One-year age changes in MRI brain volumes in older adults. Cereb Cortex 2000;10:464–472
    Abstract/FREE Full Text
  36. ↵
    Scahill RI, Frost C, Jenkins R, Whitwell JL, Rossor MN, Fox NC. A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging. Arch Neurol 2003;60:989–994
    CrossRefPubMedWeb of Science
  37. ↵
    Luks TL, Goodkin DE, Nelson SJ, et al. A longitudinal study of ventricular volume in early relapsing-remitting multiple sclerosis. Mult Scler 2000;6:332–337
    Abstract/FREE Full Text
  38. ↵
    Kalkers NF, Ameziane N, Bot JC, Minneboo A, Polman CH, Barkhof F. Longitudinal brain volume measurement in multiple sclerosis: rate of brain atrophy is independent of the disease subtype. Arch Neurol 2002;59:1572–1576
    CrossRefPubMedWeb of Science
  39. ↵
    Turner B, Lin X, Calmon G, Roberts N, Blumhardt LD. Cerebral atrophy and disability in relapsing-remitting and secondary progressive multiple sclerosis over four years. Mult Scler 2003;9:21–27
    Abstract/FREE Full Text
  40. ↵
    Rovaris M, Bozzali M, Santuccio G, et al. In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis. Brain 2001;124:2540–2549
    Abstract/FREE Full Text
  41. ↵
    Cifelli A, Arridge M, Jezzard P, Esiri MM, Palace J, Matthews PM. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002;52:650–653
    CrossRefPubMedWeb of Science
  42. ↵
    Bakshi R, Dmochowski J, Shaikh ZA, Jacobs L. Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients. J Neurol Sci 2001;185:19–26
    CrossRefPubMedWeb of Science
  43. ↵
    Wylezinska M, Cifelli A, Jezzard P, Palace J, Alecci M, Matthews PM. Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. Neurology 2003;60:1949–1954
    Abstract/FREE Full Text
  44. ↵
    Rovaris M, Bozzali M, Iannucci G, et al. Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study. Arch Neurol 2002;59:1406–1412
    CrossRefPubMedWeb of Science
  45. ↵
    Bobholz JA, Rao SM. Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol 2003;16:283–288
    CrossRefPubMedWeb of Science
  46. ↵
    Fox NC, Jenkins R, Leary SM, et al. Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI. Neurology 2000;54:807–812
    Abstract/FREE Full Text
  47. ↵
    Stevenson VL, Miller DH, Leary SM, et al. One year follow up study of primary and transitional progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 2000;68:713–718
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 26 (2)
American Journal of Neuroradiology
Vol. 26, Issue 2
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Elisabetta Pagani, Maria A. Rocca, Antonio Gallo, Marco Rovaris, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi
Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype
American Journal of Neuroradiology Feb 2005, 26 (2) 341-346;

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Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype
Elisabetta Pagani, Maria A. Rocca, Antonio Gallo, Marco Rovaris, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi
American Journal of Neuroradiology Feb 2005, 26 (2) 341-346;
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